Results 21 to 30 of about 2,150,147 (255)

A Novel Ig Domain–Containing C-Type Lectin Triggers the Intestine–Hemocyte Axis to Regulate Antibacterial Immunity in Crab

Journal of Immunology, 2022
The C-type lectin family with the signature C-type lectin–like domain promotes antibacterial host defense within the animal kingdom. We examined the role of Chinese mitten crab, Eriocheir sinensis (H.
Kaimin Zhou, Yukai Qin, Yulu Song, Ke Zhao, W. Pan, Xingyu Nan, Yue Wang, Qun Wang, Weiwei Li   +8 more
semanticscholar   +1 more source

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin.

Journal of Clinical Investigation, 2020
Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well defined, little is known about the regulation of osteoclasts by osteocyte death.
D. Andreev, Mengdan Liu, D. Weidner, K. Kachler, Maria Faas, Anika Grüneboom, U. Schlötzer-Schrehardt, L. Munoz, U. Steffen, Bettina Grötsch, Barbara Killy, G. Krönke, A. Luebke, A. Niemeier, F. Wehrhan, R. Lang, G. Schett, A. Bozec   +17 more
semanticscholar   +1 more source

Signalling through C-type lectin receptors: shaping immune responses

Nature reviews. Immunology, 2009
C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T ...
T. Geijtenbeek, Sonja I Gringhuis
semanticscholar   +1 more source

From structure to function – Ligand recognition by myeloid C-type lectin receptors

Computational and Structural Biotechnology Journal, 2022
Graphical ...
S. Fischer, Felix Stegmann, V. Gnanapragassam, B. Lepenies   +3 more
semanticscholar   +1 more source

A novel C-type lectin activates the complement cascade in the primitive oyster Crassostrea gigas

Journal of Biological Chemistry, 2021
The ancient origin of the lectin pathway of the complement system can be traced back to protochordates (such as amphioxus and tunicates) by the presence of components such as ficolin, glucose-binding lectin, mannose-binding lectin-associated serine ...
Jiejie Sun, Liyan Wang, Wenwen Yang, Yinan Li, Yingnan Jin, Lingling Wang, Linsheng Song   +6 more
semanticscholar   +1 more source

The Dectin-1 and Dectin-2 clusters: C-type lectin receptors with fundamental roles in immunity. [PDF]

EMBO Rep
The ability of myeloid cells to recognize and differentiate endogenous or exogenous ligands rely on the presence of different transmembrane protein receptors.
Malamud M, Brown GD.
europepmc   +2 more sources

BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction

Journal of Experimental Medicine, 2001
Plasmacytoid dendritic cells are present in lymphoid and nonlymphoid tissue and contribute substantially to both innate and adaptive immunity. Recently, we have described several monoclonal antibodies that recognize a plasmacytoid dendritic cell-specific
A. Dzionek, Y. Sohma, J. Nagafune, M. Cella, M. Colonna, F. Facchetti, G. Günther, I. Johnston, A. Lanzavecchia, T. Nagasaka, T. Okada, W. Vermi, Gregor Winkels, Terumi Yamamoto, Monika Zysk, Y. Yamaguchi, J. Schmitz   +16 more
semanticscholar   +1 more source

C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity

Frontiers in Immunology, 2020
C-type lectin-like receptors (CLRs) represent a family of transmembrane pattern recognition receptors, expressed primarily by myeloid cells. They recognize not only pathogen moieties for host defense, but also modified self-antigens such as damage ...
Marion Drouin, J. Saenz, Elise Chiffoleau   +2 more
semanticscholar   +1 more source

Lectins with Potential for Anti-Cancer Therapy

Molecules, 2015
This article reviews lectins of animal and plant origin that induce apoptosis and autophagy of cancer cells and hence possess the potential of being developed into anticancer drugs. Apoptosis-inducing lectins encompass galectins, C-type lectins, annexins,
Tammy Yau, Xiuli Dan, Charlene Cheuk Wing Ng, Tzi Bun Ng   +3 more
doaj   +1 more source

MCL and mincle: C-type lectin receptors that sense damaged self and pathogen associated molecular patterns

Frontiers in Immunology, 2014
MCL (macrophage C-type lectin) and mincle (macrophage inducible C-type lectin) comprise part of an extensive repertoire of pattern recognition receptors with the ability to sense damage associated and pathogen associated molecular patterns.
Mark B Richardson, Spencer J Williams
doaj   +1 more source