Results 21 to 30 of about 239,318 (305)

Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia

Haematologica, 2010
Background C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells.
Xiaoxian Zhao, Shweta Singh, Cecile Pardoux, Jingsong Zhao, Eric D. Hsi, Arie Abo, Wouter Korver   +6 more
doaj   +1 more source

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed, Bee K. Tan, Botto, Bouyain, Caparros, Carlow, Ceriello, Chaipan, Daniel A. Mitchell, Daniel Zehnder, Devaraj, Elizabeth J. Soilleux, Feinberg, Fernandez-Real, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghanim, Gringhuis, Guo, Harpal S. Randeva, Held, Hendrik Lehnert, Holman, Ip, Krutzik, Lee, Lillegard, Mitchell, Moller-Kristensen, Nauta, Paidassi, Paul Townsend, Permana, Pohlmann, Reading, Rebecca Ilyas, Robert B. Sim, Russell Wallis, Savill, Schilder, Seelen, Soilleux, Strong, Stuart, Turner, Turner, UKPDS, Wallis, Walport, Walport, Weis, Weis, Worthley, Zeyda   +54 more
core   +1 more source

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]

, 2012
C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Akira, Anders, Bjorge, Camby, Caminschi, Christoph Römmele, Elola, Ferwerda, Geijtenbeek, Gingras, Gringhuis, Gross, Hans-Joachim Anders, Heil, Heni Eka Susanti, Hornung, Kimbrell, Kock, Kono, Kronin, Kulkarni, Lassen, Lech, Lech, Lech, Lopez-Guisa, Maciej Lech, Medzhitov, Mocsai, Osorio, Patole, Rakoff-Nahoum, Regina Gröbmayr, Roman Günthner, Schreibelt, Skuginna, Van Vliet, Wagner, Zarember, Zhang   +39 more
core   +5 more sources

How C-type lectins detect pathogens. [PDF]

Cellular microbiology, 2005
Glycosylation of proteins has proven extremely important in a variety of cellular processes, including enzyme trafficking, tissue homing and immune functions. In the past decade, increasing interest in carbohydrate-mediated mechanisms has led to the identification of novel carbohydrate-recognizing receptors expressed on cells of the immune system ...
Cambi, A., Koopman, M., Figdor, C.G.
openaire   +5 more sources

Association of circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 with inflammatory markers and urinary albumin excretion in patients with type 2 diabetes

SAGE Open Medicine, 2021
Objectives: The main purpose of the study was to study the association between circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels and various markers, including inflammatory markers such as high-sensitivity C-reactive ...
Kohzo Takebayashi, Tatsuhiko Suzuki, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Toshihiko Inukai, Koshi Hashimoto   +6 more
doaj   +1 more source

BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family [PDF]

, 2013
Natural Killer Gene Complex (NKC)–encoded C-type lectin-like receptors (CTLRs) are expressed on various immune cells including T cells, NK cells and myeloid cells and thereby contribute to the orchestration of cellular immune responses.
Lysenko, Olga, Mittelbronn, Michel Guy André, Schulte, Dorothea, Steinle, Alexander   +3 more
core   +4 more sources

Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors. [PDF]

PLoS ONE, 2013
Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and immunocompromised individuals to ...
Matthew Brudner, Marshall Karpel, Calli Lear, Li Chen, L Michael Yantosca, Corinne Scully, Ashish Sarraju, Anna Sokolovska, M Reza Zariffard, Damon P Eisen, Bruce A Mungall, Darrell N Kotton, Amel Omari, I-Chueh Huang, Michael Farzan, Kazue Takahashi, Lynda Stuart, Gregory L Stahl, Alan B Ezekowitz, Gregory T Spear, Gene G Olinger, Emmett V Schmidt, Ian C Michelow   +22 more
doaj   +1 more source

Lectins with Potential for Anti-Cancer Therapy

Molecules, 2015
This article reviews lectins of animal and plant origin that induce apoptosis and autophagy of cancer cells and hence possess the potential of being developed into anticancer drugs. Apoptosis-inducing lectins encompass galectins, C-type lectins, annexins,
Tammy Yau, Xiuli Dan, Charlene Cheuk Wing Ng, Tzi Bun Ng   +3 more
doaj   +1 more source

The Rosetteless gene controls development in the choanoflagellate S. rosetta. [PDF]

, 2014
The origin of animal multicellularity may be reconstructed by comparing animals with one of their closest living relatives, the choanoflagellate Salpingoeca rosetta.
Greaney, Allison J, King, Nicole, Levin, Tera C, Wetzel, Laura   +3 more
core   +1 more source

C-type lectins and phagocytosis

Immunobiology, 2009
To recognise and respond to pathogens, germ-line encoded pattern recognition receptors (PRRs) bind to conserved microbial structures and activate host defence systems, including microbial uptake by phagocytosis. Phagocytosis is a complex process that is instrumental in the control of extracellular pathogens, and this activity is mediated by several ...
Kerrigan, Ann, Brown, Gordon D
openaire   +3 more sources