Results 1 to 10 of about 108,848 (254)

Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity [PDF]

Frontiers in Immunology, 2018
Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity.
Juan Tang, Guoxin Lin, Guoxin Lin, Wallace Y. Langdon, Lijian Tao, Jian Zhang   +5 more
doaj   +7 more sources

Development of Negative Controls for Fc-C-Type Lectin Receptor Probes [PDF]

Microbiology Spectrum, 2023
Fc-C-type lectin receptor (Fc-CTLRs) probes are soluble chimeric proteins constituted of the extracellular domain of a CTLR fused with the constant fraction (Fc) of the human IgG. These probes are useful tools to study the interaction of CTLRs with their
Rémi Hatinguais, Madalaine Kay, Fabián Salazar, Daniel P. Conn, David L. Williams, Peter C. Cook, Janet A. Willment, Gordon D. Brown   +7 more
doaj   +2 more sources

Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2 [PDF]

eLife, 2022
C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment, Gordon D Brown, Masamichi Nagae, Sho Yamasaki   +12 more
doaj   +2 more sources

The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan [PDF]

mBio, 2023
Aspergillus fumigatus is a ubiquitous environmental mold that causes significant mortality particularly among immunocompromised patients. The detection of the Aspergillus-derived carbohydrate galactomannan in patient serum and bronchoalveolar lavage ...
Jennifer L. Reedy, Arianne J. Crossen, Paige E. Negoro, Hannah Brown Harding, Rebecca A. Ward, Diego A. Vargas-Blanco, Kyle D. Timmer, Christopher M. Reardon, Kyle J. Basham, Michael K. Mansour, Marcel Wüthrich, Thierry Fontaine, Jean-Paul Latgé, Jatin M. Vyas   +13 more
doaj   +2 more sources

C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis [PDF]

Nature Communications, 2022
The contribution of distinct subsets of macrophages to atherosclerosis is poorly understood. Here the authors describe a protective subset of vascular macrophages expressing the C-type lectin receptor CLEC4A2, which licenses monocytes to join the ...
Inhye Park, Michael E. Goddard, Jennifer E. Cole, Natacha Zanin, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Evangelos Andreakos, Marc Feldmann, Irina Udalova, Ignat Drozdov, Claudia Monaco   +10 more
doaj   +2 more sources

Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens [PDF]

Frontiers in Cell and Developmental Biology, 2020
Langerhans cells (LCs) are antigen-presenting cells that reside in the skin. They uniquely express high levels of the C-type lectin receptor Langerin (CD207), which is an attractive target for antigen delivery in immunotherapeutic vaccination strategies ...
Rui-Jun Eveline Li, Tim P. Hogervorst, Silvia Achilli, Sven C. M. Bruijns, Sander Spiekstra, Corinne Vivès, Michel Thépaut, Dmitri V. Filippov, Gijs A. van der Marel, Sandra J. van Vliet, Franck Fieschi, Jeroen D. C. Codée, Yvette van Kooyk   +12 more
doaj   +2 more sources

C-type lectin receptor DCIR contributes to hippocampal injury in acute neurotropic virus infection [PDF]

Scientific Reports, 2021
Neurotropic viruses target the brain and contribute to neurologic diseases. C-type lectin receptors (CLRs) are pattern recognition receptors that recognize carbohydrate structures on endogenous molecules and pathogens.
Melanie Stoff, Tim Ebbecke, Malgorzata Ciurkiewicz, Suvarin Pavasutthipaisit, Sabine Mayer-Lambertz, Theresa Störk, Kevin D. Pavelko, Wolfgang Baumgärtner, Klaus Jung, Bernd Lepenies, Andreas Beineke   +10 more
doaj   +2 more sources

MGL/CLEC10A is an important C-type lectin receptor activated in the innate immune response to Mycobacterium tuberculosis and is suppressed in people with HIV [PDF]

Frontiers in Immunology
Mycobacterium tuberculosis (Mtb) and HIV are leading infectious causes of death worldwide and act synergistically to worsen disease during co-infection.
Sarah E. Browning, Preeti Bharaj, Xiuzhen Fan, Harrison Nguyen, Alex J. Holloway, Kubra F. Naqvi, Joshua G. Lisinicchia, Reina N. Paez, Sadhana Chauhan, Matthew B. Huante, Yazmin B. Martinez-Martinez, Mark A. Endsley, Benjamin B. Gelman, Janice J. Endsley   +13 more
doaj   +2 more sources

Association of circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 with inflammatory markers and urinary albumin excretion in patients with type 2 diabetes

SAGE Open Medicine, 2021
Objectives: The main purpose of the study was to study the association between circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels and various markers, including inflammatory markers such as high-sensitivity C-reactive ...
Kohzo Takebayashi, Tatsuhiko Suzuki, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Toshihiko Inukai, Koshi Hashimoto   +6 more
doaj   +1 more source

Investigations of asialoglycoprotein receptor glycosylation by lectin affinity methods [PDF]

Journal of the Serbian Chemical Society, 2002
The asialoglycoprotein receptor belongs to the family of calcium-dependent (C-type) animal lectins. The purified receptor is a glycoprotein in which 10 % of the dry weight consists of sialic acid, galactose, N-acetylglucosamine and mannose.
Baričević Ivona I., Vićovac-Panić Ljiljana M., Marinović Vesna, Čuperlović Margita   +3 more
doaj   +1 more source