Results 201 to 210 of about 85,647 (228)

Signaling C-Type Lectin Receptors in Antifungal Immunity

2020
We are all exposed to fungal organisms daily, and although many of these organisms are not harmful, billions of people a year contract a fungal infection. Most of these infections are not fatal and can be cleared by the host immune response. However, due to an increase in high-risk populations, the global fungal burden has increased, with more than 1.5
Maxine A, Höft, J Claire, Hoving, Gordon D, Brown   +2 more
openaire   +2 more sources

Immunobiology of C-Type Lectin Receptors

2013
C-type lectin receptors (CLRs) that signal via the kinase Syk are an important class of pattern recognition receptors in the innate immune system. They recognize pathogen- and host-derived danger signals, and are best known for their role in antifungal immunity.
Susanne Roth, Christina Thomas, Jürgen Ruland   +2 more
openaire   +1 more source

Archaeal Glycerolipids Are Recognized by C-Type Lectin Receptor Mincle

Journal of the American Chemical Society, 2023
Recently, various metabolites derived from host microbes have been reported to modulate the immune system, with potential involvement in health or diseases. Archaea, prokaryotic organisms, are present in the human body, but their connection with the host is largely unknown when compared to other microorganisms such as bacteria.
Shiori Oka, Miyuki Watanabe, Emi Ito, Ami Takeyama, Takuro Matsuoka, Masatomo Takahashi, Yoshihiro Izumi, Norihito Arichi, Hiroaki Ohno, Sho Yamasaki, Shinsuke Inuki   +10 more
openaire   +2 more sources

C-type lectin receptors and cytokines in fungal immunity

Cytokine, 2012
Fungi are the cause of opportunistic infections, predominantly in immunocompromised individuals although, primary fungal infections can occur in apparently healthy individuals. Successful host defence requires an effective innate and adaptive immune response.
Simon, Vautier, Donna M, MacCallum, Gordon D, Brown   +2 more
openaire   +2 more sources

The C-Type Lectin Receptors

C-type lectins (CTLs) form a broad and diverse protein superfamily with the ability to identify a wide array of ligands with their characteristic C-type lectin-like domains (CTLDs), thus governing a broad spectrum of physiological functions. CTLD-containing proteins (CTLDcps) are now classified into 17 groups based on their phylogeny and overall domain
Kasturi, Ganguly, Taruna, Madan
openaire   +2 more sources

The role of C-type lectin receptors in immune homeostasis

International Immunopharmacology, 2013
C-type lectin receptors (CLRs) are important pathogen pattern recognition molecules that recognize carbohydrate structures. Upon ligand binding, CLRs induce a variety of cellular responses, such as respiratory burst, production of cytokines and chemokines, and consequently shaping the adaptive immune responses. Recent frontier studies have demonstrated
Huimin, Yan, Naohito, Ohno, Noriko M, Tsuji   +2 more
openaire   +2 more sources

Snake C-Type Lectin-Like Proteins and Platelet Receptors

Pathophysiology of Haemostasis and Thrombosis, 2005
Snake venoms are complex mixtures of biologically active proteins and peptides. Many affect haemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium. Snake venom components are classified into various families, such as serine proteases, metalloproteinases, C-type lectin-like proteins, disintegrins and ...
Clemetson KJ, Lu Q, Clemetson JM
openaire   +3 more sources

C-type lectin receptors on dendritic cells and langerhans cells

Nature Reviews Immunology, 2002
Dendritic cells and Langerhans cells are specialized for the recognition of pathogens and have a pivotal role in the control of immunity. As guardians of the immune system, they are present in essentially every organ and tissue, where they operate at the interface of innate and acquired immunity.
Figdor, C.G., Kooyk, Y. van, Adema, G.J.
openaire   +4 more sources

Targeting C-type lectin receptors with multivalent carbohydrate ligands

Advanced Drug Delivery Reviews, 2013
C-type lectin receptors (CLRs) represent a large receptor family including collectins, selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous carbohydrate-recognition domain (CRD) and often bind carbohydrates in a Ca²⁺-dependent manner.
Junghoon Lee, Bernd Lepenies, Sanjiv Sonkaria   +2 more
exaly   +4 more sources

The CD94/NKG2 C-Type Lectin Receptor Complex

1998
A multigene family of human Ig-SF receptors and members of the murine Ly49 C-type lectin family are involved in natural killer (NK) cell-mediated recognition of MHC class I molecules. The human CD94 glycoprotein covalently assembles with different C-type lectins of the NKG2 family.
M, López-Botet, M, Carretero, T, Bellón, J J, Pérez-Villar, M, Llano, F, Navarro   +5 more
openaire   +2 more sources