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The diverse roles of C-type lectin-like receptors in immunity [PDF]
Frontiers in Immunology, 2023 Our understanding of the C-type lectin-like receptors (CTLRs) and their functions in immunity have continued to expand from their initial roles in pathogen recognition.
Michal Scur +3 more
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C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets [PDF]
Frontiers in Immunology, 2018 Over the last decade, C-type lectin-like receptors (CTLRs), expressed mostly by myeloid cells, have gained increasing attention for their role in the fine tuning of both innate and adaptive immunity.
Elise Chiffoleau +3 more
doaj +9 more sources
C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity [PDF]
Frontiers in Immunology, 2020 C-type lectin-like receptors (CLRs) represent a family of transmembrane pattern recognition receptors, expressed primarily by myeloid cells. They recognize not only pathogen moieties for host defense, but also modified self-antigens such as damage ...
Marion Drouin +3 more
doaj +8 more sources
Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases [PDF]
International Journal of Molecular Sciences, 2020 The innate immune system identifies exogenous threats or endogenous stress through germline-encoded receptors called pattern recognition receptors (PRRs) that initiate consecutive downstream signaling pathways to control immune responses. However, the contribution of the immune system and inflammation to fibrosing interstitial lung diseases (ILD ...
Wiwin Is EFFENDI, Tatsuya Nagano
exaly +6 more sources
C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map
Cancer Management and Research, 2012 Anton G Kutikhin, Arseniy E YuzhalinDepartment of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian FederationAbstract: The group of pattern recognition receptors includes families of Toll-like receptors, NOD-like receptors, C-type lectin ...
Yuzhalin AE, Kutikhin AG
doaj +3 more sources
The Dectin-2 family of C-type lectin-like receptors: an update [PDF]
International Immunology, 2013 Myeloid and non-myeloid cells express members of the C-type lectin-like receptor (CTLR) family, which mediate crucial cellular functions during immunity and homeostasis. Of relevance here is the dendritic cell-associated C-type lectin-2 (Dectin-2) family of CTLRs, which includes blood dendritic cell antigen 2 (BDCA-2), dendritic cell immunoactivating ...
Bernhard Kerscher +2 more
exaly +6 more sources
C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways [PDF]
International Reviews of Immunology, 2013 Innate immunity is constructed around genetically encoded receptors that survey the intracellular and extracellular environments for signs of invading microorganisms. These receptors recognise the invader and through complex intracellular networks of molecular signaling, they destroy the threat whilst instructing effective adaptive immune responses ...
Janet A Willment, Gordon D Brown
exaly +6 more sources
Snake C-Type Lectin-Like Proteins and Platelet Receptors
Pathophysiology of Haemostasis and Thrombosis, 2005 Snake venoms are complex mixtures of biologically active proteins and peptides. Many affect haemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium. Snake venom components are classified into various families, such as serine proteases, metalloproteinases, C-type lectin-like proteins, disintegrins and ...
Clemetson KJ, Lu Q, Clemetson JM
openaire +4 more sources
Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells. [PDF]
Sci Rep, 2019 AbstractWorking at the border between innate and adaptive immunity, natural killer (NK) cells play a key role in the immune system by protecting healthy cells and by eliminating malignantly transformed, stressed or virally infected cells. NK cell recognition of a target cell is mediated by a receptor “zipper” consisting of various activating and ...
Vaněk O +14 more
europepmc +7 more sources
C-type lectin receptor signaling in schistosomiasis [PDF]
Frontiers in ImmunologySchistosomiasis is a major neglected tropical disease caused by helminth parasites of the genus Schistosoma, affecting over 250 million people worldwide and leading to substantial morbidity primarily driven by egg-induced immunopathology.
Santoshi Chaudhary, Parisa Kalantari
doaj +2 more sources