Results 41 to 50 of about 117,277 (324)

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +5 more sources

The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen presenting cells [PDF]

, 2012
The C-type lectin DC-SIGN expressed on dendritic cells (DCs) facilitates capture and internalization of a plethora of different pathogens. Although it is known that DC-SIGN organizes in nanoclusters at the surface of DCs, the molecular mechanisms ...
Alvarez, Ashby, Bakker, Banchereau, Bonifaz, Cambi, Cambi, Cambi, Cambi, Cambi, Chung, de Bakker, de Witte, Feinberg, Feinberg, Gaborski, Geijtenbeek, Geijtenbeek, Geijtenbeek, Geijtenbeek, Gringhuis, Itano, Itano, Khoo, Koopman, Liu, Liu, Lozach, Lozach, Ludwig, Menon, Mitchell, Neumann, Pohlmann, Puig-Kröger, Rappocciolo, Regan, Serrano-Gómez, Sierra-Filardi, Simmons, Smith, Soilleux, Steinman, Tacken, Tacken, Théry, Trombetta, van Kooyk, Yu, Zhu   +49 more
core   +5 more sources

C‐type lectin‐like receptors on myeloid cells

Annals of Medicine, 2006
Host defence against pathogens requires the recognition of conserved microbial molecules, or 'pathogen-associated molecular patterns' (PAMPs), by their receptors termed 'pattern recognition receptors' (PRRs), represented most notably by toll-like receptors (TLRs) and C-type lectins.
Elwira, Pyz, Andrew S J, Marshall, Siamon, Gordon, Gordon D, Brown   +3 more
openaire   +2 more sources

Association of arthritis with a gene complex encoding C‐type lectin–like receptors [PDF]

Arthritis & Rheumatism, 2007
AbstractObjectiveTo identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA.MethodsGenes influencing oil‐induced arthritis (OIA) were position mapped by comparing the susceptibility of inbred DA rats with that of DA rats carrying alleles derived from the ...
Johnny C, Lorentzen, Line, Flornes, Carina, Eklöw, Liselotte, Bäckdahl, Ulrica, Ribbhammar, Jian Ping, Guo, Marina, Smolnikova, Erik, Dissen, Maria, Seddighzadeh, Anthony J, Brookes, Lars, Alfredsson, Lars, Klareskog, Leonid, Padyukov, Sigbjörn, Fossum   +13 more
openaire   +2 more sources

Role of the C-type lectin receptors MCL and DCIR in experimental colitis. [PDF]

PLoS ONE, 2014
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Though its exact etiology is still unclear, it is proposed that an imbalance in the intestinal homeostasis leads to a disturbed interaction between ...
Julia Hütter, Magdalena Eriksson, Timo Johannssen, Robert Klopfleisch, Dorthe von Smolinski, Achim D Gruber, Peter H Seeberger, Bernd Lepenies   +7 more
doaj   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Snake C-Type Lectin-Like Proteins and Platelet Receptors

Pathophysiology of Haemostasis and Thrombosis, 2005
Snake venoms are complex mixtures of biologically active proteins and peptides. Many affect haemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium. Snake venom components are classified into various families, such as serine proteases, metalloproteinases, C-type lectin-like proteins, disintegrins and ...
Clemetson, Kenneth John, Lu, Qiumin, Clemetson, Jeannine   +2 more
openaire   +3 more sources

Arabidopsis lectin EULS3 is involved in ABA signaling in roots [PDF]

, 2020
The Arabidopsis thaliana lectin ArathEULS3 is upregulated in particular stress conditions and upon abscisic acid (ABA) treatment. ABA is a plant hormone important for plant growth and stress responses.
Beeckman, Tom, Dubiel, Malgorzata, Smagghe, Guy, Van Damme, Els   +3 more
core   +1 more source

AmpliSeq screening of genes encoding the C-Type lectin receptors and their signaling components reveals a common variant in MASP1 associated with pulmonary tuberculosis in an Indian population [PDF]

, 2018
Tuberculosis (TB) is a multifactorial disease governed by bacterial, host and environmental factors. On the host side, growing evidence shows the crucial role that genetic variants play in the susceptibility to Mycobacterium tuberculosis (Mtb) infection.
Abid Hussain, Carlos Flores, Carlos Flores, Carlos Flores, Dominik Driesch, Gaddam Sumanlatha, Hortense Slevogt, Luis Carlos Berrocal-Almanza, Magdalena Stock, Niyaz Ahmed, Rajashekar Myakala, Ralf R. Schumann, Surabhi Goyal, Tilman E. Klassert, Vijayalakshmi Valluri   +14 more
core   +3 more sources

Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. [PDF]

, 2019
Natural killer (NK) cells of the innate immune system are a key focus of research within the field of immuno-oncology based on their ability to recognize and eliminate malignant cells without prior sensitization or priming.
Canter, Robert J, Gingrich, Alicia A, Modiano, Jaime F   +2 more
core   +2 more sources