Results 21 to 30 of about 28,074,578 (229)

C‐type lectin‐like receptors on myeloid cells

Annals of Medicine, 2006
Host defence against pathogens requires the recognition of conserved microbial molecules, or 'pathogen-associated molecular patterns' (PAMPs), by their receptors termed 'pattern recognition receptors' (PRRs), represented most notably by toll-like receptors (TLRs) and C-type lectins.
Elwira, Pyz, Andrew S J, Marshall, Siamon, Gordon, Gordon D, Brown   +3 more
openaire   +2 more sources

Association of arthritis with a gene complex encoding C‐type lectin–like receptors [PDF]

Arthritis & Rheumatism, 2007
AbstractObjectiveTo identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA.MethodsGenes influencing oil‐induced arthritis (OIA) were position mapped by comparing the susceptibility of inbred DA rats with that of DA rats carrying alleles derived from the ...
Johnny C, Lorentzen, Line, Flornes, Carina, Eklöw, Liselotte, Bäckdahl, Ulrica, Ribbhammar, Jian Ping, Guo, Marina, Smolnikova, Erik, Dissen, Maria, Seddighzadeh, Anthony J, Brookes, Lars, Alfredsson, Lars, Klareskog, Leonid, Padyukov, Sigbjörn, Fossum   +13 more
openaire   +2 more sources

BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family [PDF]

, 2013
Natural Killer Gene Complex (NKC)–encoded C-type lectin-like receptors (CTLRs) are expressed on various immune cells including T cells, NK cells and myeloid cells and thereby contribute to the orchestration of cellular immune responses.
Mittelbronn, Michel Guy André, Michel Mittelbronn, Olga Lysenko (420632), Alexander Steinle (254716), Schulte, Dorothea, Lysenko, Olga, Dorothea Schulte, Steinle, Alexander, Alexander Steinle, Dorothea Schulte (420633), Olga Lysenko, Michel Mittelbronn (307400)   +11 more
core   +1 more source

Characterisation of bovine leukocyte Ig-like receptors [PDF]

, 2012
Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have ...
Laing Ken, Martin Vordermeier, John Trowsdale, Singh Mahavir, Philip Butcher (173962), Allen Rachel L., Ken Laing, Laing, K, Butcher, P, Mahavir Singh, Des C Jones, Butcher, Philip, Bhuju, S, Ken Laing (173955), Vordermeier, M, Singh, Mahavir, Jones, DC, Trowsdale, John, Mahavir Singh (70735), Rachel L Allen, Hogan, Louise, Trowsdale, J, Hogan Louise, Vordermeier Martin, Hogan, L, Philip Butcher, Singh, M, Allen, RL, Des C. Jones (173949), Louise Hogan (173942), John Trowsdale (1225), Martin Vordermeier (108962), Trowsdale John, Vordermeier, Martin, Allen, Rachel L, Jones Des C., Sabin Bhuju, Laing, Ken, Bhuju Sabin, Sabin Bhuju (107606), Rachel L. Allen (173972), Jones, Des C, Bhuju, Sabin, Louise Hogan, Butcher Philip   +44 more
core   +4 more sources

Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human Natural Killer Gene Complex (NKC)

Frontiers in Immunology, 2013
Functional responses of Natural Killer (NK) cells including eradication of ‘harmful’ cells and modulation of immune responses are regulated by a broad variety of activating and inhibitory NK receptors. Whereas the leukocyte receptor complex (LRC) encodes
Yvonne eBartel, Björn eBauer, Alexander eSteinle   +2 more
doaj   +1 more source

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]

, 2012
C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Lech, Maciej, Günthner, Roman, Regina Gröbmayr, Römmele, Christoph, Heni Eka Susanti, Susanti, Heni Eka, Heni Susanti, Maciej Lech, Roman Günthner, Hans-Joachim Anders, Christoph Römmele, Gröbmayr, Regina, Anders, Hans-Joachim   +12 more
core   +1 more source

Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver Injury in Mice [PDF]

The American Journal of Pathology, 2020
Cholestatic liver injury leads to liver dysfunction. The available evidence suggests that platelets can either promote or reduce liver injury and fibrosis. This study focused on the functions of the C-type lectin-like receptor 2 (CLEC-2), a new special platelet receptor that binds with podoplanin-activating platelets.
Suguru, Maruyama, Hiroshi, Kono, Shinji, Furuya, Hiroki, Shimizu, Ryo, Saito, Katsutoshi, Shoda, Hidenori, Akaike, Naohiro, Hosomura, Yoshihiko, Kawaguchi, Hidetake, Amemiya, Hiromichi, Kawaida, Makoto, Sudo, Shingo, Inoue, Toshiaki, Shirai, Katsue, Suzuki-Inoue, Daisuke, Ichikawa   +15 more
openaire   +2 more sources

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Bee K. Tan, Robert B. Sim, Russell Wallis, Tan, Bee K., Elizabeth J. Soilleux, Townsend, Paul, Wallis, Russell, Soilleux, Elizabeth J., Paul Townsend, Daniel A. Mitchell, Randeva, Harpal S., Sim, Robert B., Hendrik Lehnert, Ilyas, Rebecca, Zehnder, Daniel, Mitchell, Daniel A., Daniel Zehnder, Rebecca Ilyas, Harpal S. Randeva, Lehnert, Hendrik   +19 more
core   +1 more source

Role of the C-type lectin receptors MCL and DCIR in experimental colitis. [PDF]

PLoS ONE, 2014
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Though its exact etiology is still unclear, it is proposed that an imbalance in the intestinal homeostasis leads to a disturbed interaction between ...
Julia Hütter, Magdalena Eriksson, Timo Johannssen, Robert Klopfleisch, Dorthe von Smolinski, Achim D Gruber, Peter H Seeberger, Bernd Lepenies   +7 more
doaj   +1 more source

BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. [PDF]

PLoS Biology, 2007
Dendritic cells are equipped with lectin receptors to sense the extracellular environment and modulate cellular responses. Human plasmacytoid dendritic cells (pDCs) uniquely express blood dendritic cell antigen 2 (BDCA2) protein, a C-type lectin lacking ...
Wei Cao, Li Zhang, David B Rosen, Laura Bover, Gokuran Watanabe, Musheng Bao, Lewis L Lanier, Yong-Jun Liu   +7 more
doaj   +1 more source