Results 21 to 30 of about 117,277 (324)

Soluble C-Type Lectin-Like Receptor 2 Is a Biomarker for Disseminated Intravascular Coagulation [PDF]

Journal of Clinical Medicine, 2021
Disseminated intravascular coagulation (DIC) is induced by excess activation coagulation, and activated platelets are also involved in pathogenesis. Therefore, plasma levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a new marker for platelet activation, can be expected as a marker of DIC in critically ill patients.
Akitaka Yamamoto, Hideo Wada, Yuhuko Ichkawa, Motoko Tanaka, Haruhiko Tashiro, Katsuya Shiraki, Hideto Shimpo, Yoshiki Yamashita, Takeshi Mastumoto, Motomu Shimaoka, Toshiaki Iba, Katsue Suzuki‐Inoue   +11 more
openalex   +4 more sources

C-type lectin-like receptor 2: roles and drug target [PDF]

Thrombosis Journal
AbstractC-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocytin, respectively. CLEC-2 is expressed on the surface of platelets, which participates in platelet activation and aggregation by binding with its ...
Lan Sun, Zhe Wang, Zhiyan Liu, Guangyan Mu, Yimin Cui, Qian Xiang   +5 more
openalex   +4 more sources

C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

Frontiers in Immunology, 2018
C-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an important role in viral infections as they efficiently interact with viruses. However,
Marta Bermejo-Jambrina, Marta Bermejo-Jambrina, Julia Eder, Leanne C. Helgers, Nina Hertoghs, Bernadien M. Nijmeijer, Melissa Stunnenberg, Teunis B. H. Geijtenbeek   +7 more
doaj   +3 more sources

C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes [PDF]

Scientific Reports, 2022
Abstract Podoplanin (PDPN) is intensely expressed on the podocyte membrane in an evolutionally conserved manner. CLEC-2, the endogenous ligand of PDPN, is highly expressed in platelets and also exists in a soluble form in plasma. Normally, podocytes are sequestered from CLEC-2, but when the glomerular barrier is injured, podocytes gain access ...
Keiko Tanaka, Masafumi Tanaka, Nobuo Watanabe, Masatoshi Ito, Ira Pastan, Masahiro Koizumi, Taiji Matsusaka   +6 more
openalex   +4 more sources

Super Formula for Diagnosing Disseminated Intravascular Coagulation Using Soluble C-Type Lectin-like Receptor 2 [PDF]

Diagnostics, 2023
The scoring systems for disseminated intravascular coagulation (DIC) criteria require several adequate cutoff values, vary, and are complicated. Accordingly, a simpler and quicker diagnostic method for DIC is needed. Under such circumstances, soluble C-type lectin-like receptor 2 (sCLEC-2) received attention as a biomarker for platelet activation ...
Akitaka Yamamoto, Hideo Wada, Masaki Tomida, Yuhuko Ichikawa, Minoru Ezaki, Katsuya Shiraki, Motomu Shimaoka, Toshiaki Iba, Katsue Suzuki‐Inoue, Masahide Kawamura, Hideto Shimpo   +10 more
openalex   +4 more sources

Treatment of Acute Myeloid Leukemia with T Cells Expressing Chimeric Antigen Receptors Directed to C-type Lectin-like Molecule 1 [PDF]

Molecular Therapy, 2017
Haruko Tashiro, Tim Sauer, Thomas Shum, Kathan Parikh, Maksim Mamonkin, Bilal Omer, Rayne H. Rouce, Premal Lulla, Cliona M. Rooney, Stephen Gottschalk, Malcolm K. Brenner   +10 more
openalex   +3 more sources

Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells. [PDF]

Sci Rep, 2019
AbstractWorking at the border between innate and adaptive immunity, natural killer (NK) cells play a key role in the immune system by protecting healthy cells and by eliminating malignantly transformed, stressed or virally infected cells. NK cell recognition of a target cell is mediated by a receptor “zipper” consisting of various activating and ...
Vaněk O, Celadova P, Skořepa O, Bláha J, Kalousková B, Dvorská A, Poláchová E, Pucholtová H, Kavan D, Pompach P, Hofbauerová K, Kopecký V, Mesci A, Voigt S, Carlyle JR.   +14 more
europepmc   +6 more sources

Galectin‐9 activates platelet ITAM receptors glycoprotein VI and C‐type lectin‐like receptor‐2 [PDF]

Journal of Thrombosis and Haemostasis, 2022
Platelets are multifunctional cellular mediators in many physiological and pathophysiological processes such as thrombosis, angiogenesis, and inflammation. Several members of galectins, a family of carbohydrate-binding proteins with a broad range of immunomodulatory actions, have been reported to activate platelets.In this study, we investigated the ...
Zhaogong Zhi, Natalie J. Jooss, Yi Sun, Martina Colicchia, Alexandre Slater, Luis A. Moran, Hilaire Yam Fung Cheung, Ying Di, Julie Rayes, Natalie S. Poulter, Steve P. Watson, Asif J. Iqbal   +11 more
openaire   +2 more sources

Fucoidan Is a Novel Platelet Agonist for the C-type Lectin-like Receptor 2 (CLEC-2) [PDF]

Journal of Biological Chemistry, 2013
Fucoidan, a sulfated polysaccharide from Fucus vesiculosus, decreases bleeding time and clotting time in hemophilia, possibly through inhibition of tissue factor pathway inhibitor. However, its effect on platelets and the receptor by which fucoidan induces cellular processes has not been elucidated.
Bhanu Kanth Manne, Todd M. Getz, Craig E. Hughes, Osama M. Alshehri, Carol Dangelmaier, Ulhas P. Naik, Steve P. Watson, Satya P. Kunapuli   +7 more
openalex   +4 more sources

BACL is a novel brain-associated, non-NKC-encoded mammalian C-type lectin-like receptor of the CLEC2 family [PDF]

, 2013
Natural Killer Gene Complex (NKC)–encoded C-type lectin-like receptors (CTLRs) are expressed on various immune cells including T cells, NK cells and myeloid cells and thereby contribute to the orchestration of cellular immune responses.
Lysenko, Olga, Mittelbronn, Michel Guy André, Schulte, Dorothea, Steinle, Alexander   +3 more
core   +13 more sources