The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. [PDF]
PLoS Pathogens, 2019 Invasive candidiasis, mainly caused by Candida albicans, is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients. Innate immune cells express pathogen recognition receptors (PRRs) including C-type lectin-like
Aiysha Thompson +11 more
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Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex [PDF]
The Scientific World Journal, 2012 Pattern recognition receptors are crucial in initiating and shaping innate and adaptive immune responses and often belong to families of structurally and evolutionarily related proteins.
Susanne Sattler +2 more
doaj +4 more sources
Pattern recognition receptor signaling in otitis media: immune crosstalk and pathogenic mechanisms [PDF]
Frontiers in ImmunologyOtitis media (OM) remains a prevalent and multifactorial inflammatory disease of the middle ear, especially in pediatric populations. The immune system, particularly pattern recognition receptors (PRRs), plays a central role in detecting microbial ...
Mingwen Guo +5 more
doaj +2 more sources
C-Type Lectin Receptors in Antiviral Immunity and Viral Escape
Frontiers in Immunology, 2018 C-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an important role in viral infections as they efficiently interact with viruses. However,
Marta Bermejo-Jambrina +7 more
doaj +2 more sources
Cell ReportsSummary: Innate immune responses can be triggered upon detection of pathogen- or damage-associated molecular patterns by host receptors that are often present on the surface of immune cells.
Kenneth Liu +5 more
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Measurement of soluble C-type lectin-like receptor 2 in human plasma [PDF]
Platelets, 2015 Detection of platelet activation in vivo is useful to identify patients at risk of thrombotic diseases. Platelet factor 4 (PF4) and β-thromboglobulin (β-TG) are used for this purpose; however, they are easily released upon the minimal platelet activation that occurs during sampling.
Fuminori, Kazama +13 more
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Key thermally dimorphic fungal pathogens: shaping host immunity
Open Biology, 2022 Exposure to fungal pathogens from the environment is inevitable and with the number of at-risk populations increasing, the prevalence of invasive fungal infection is on the rise. An interesting group of fungal organisms known as thermally dimorphic fungi
Maxine A. Höft +2 more
doaj +1 more source
Innate Immune Sensing of Viruses and Its Consequences for the Central Nervous System
Viruses, 2021 Viral infections remain a global public health concern and cause a severe societal and economic burden. At the organismal level, the innate immune system is essential for the detection of viruses and constitutes the first line of defense.
Hina Singh, Jeffrey Koury, Marcus Kaul
doaj +1 more source
The Role of Lectin Receptors and Their Ligands in Controlling Allergic Inflammation
Frontiers in Immunology, 2021 More than fifty c-type lectin receptors (CLR) are known and have been identified so far. Moreover, we know the group of galectins and sialic acid-binding immunoglobulin-type lectins that also belong to the carbohydrate-binding receptors of the immune ...
Karin Peters, Marcus Peters
doaj +1 more source
Galectin‐9 activates platelet ITAM receptors glycoprotein VI and C‐type lectin‐like receptor‐2 [PDF]
Journal of Thrombosis and Haemostasis, 2022 Platelets are multifunctional cellular mediators in many physiological and pathophysiological processes such as thrombosis, angiogenesis, and inflammation. Several members of galectins, a family of carbohydrate-binding proteins with a broad range of immunomodulatory actions, have been reported to activate platelets.In this study, we investigated the ...
Zhaogong Zhi +11 more
openaire +2 more sources