Results 11 to 20 of about 28,074,578 (229)

Snake C-Type Lectin-Like Proteins and Platelet Receptors

Pathophysiology of Haemostasis and Thrombosis, 2005
Snake venoms are complex mixtures of biologically active proteins and peptides. Many affect haemostasis by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium. Snake venom components are classified into various families, such as serine proteases, metalloproteinases, C-type lectin-like proteins, disintegrins and ...
Clemetson KJ, Lu Q, Clemetson JM
core   +5 more sources

Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex [PDF]

The Scientific World Journal, 2012
Pattern recognition receptors are crucial in initiating and shaping innate and adaptive immune responses and often belong to families of structurally and evolutionarily related proteins.
Susanne Sattler, Hormas Ghadially, Erhard Hofer   +2 more
doaj   +4 more sources

Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells [PDF]

Scientific Reports, 2019
AbstractWorking at the border between innate and adaptive immunity, natural killer (NK) cells play a key role in the immune system by protecting healthy cells and by eliminating malignantly transformed, stressed or virally infected cells. NK cell recognition of a target cell is mediated by a receptor “zipper” consisting of various activating and ...
Ondřej Vaněk, Petra Celadova, Ondřej Skořepa, Jan Bláha, Barbora Kalousková, Anna Dvorská, Edita Poláchová, Helena Pucholtová, Daniel Kavan, Petr Pompach, Kateřina Hofbauerová, Vladimír Kopecký, Aruz Mesci, Sebastian Voigt, James R. Carlyle   +14 more
openaire   +5 more sources

C-Type Lectin Receptors in Antiviral Immunity and Viral Escape [PDF]

Frontiers in Immunology, 2018
C-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an important role in viral infections as they efficiently interact with viruses. However,
Marta Bermejo-Jambrina, Marta Bermejo-Jambrina, Julia Eder, Leanne C. Helgers, Nina Hertoghs, Bernadien M. Nijmeijer, Melissa Stunnenberg, Teunis B. H. Geijtenbeek   +7 more
doaj   +2 more sources

Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins [PDF]

, 2010
Tetraspanins are a superfamily of glycoproteins that function as ‘organisers’ of membranes by clustering with each other to form tetraspanin-enriched microdomains, into which certain other receptors and signalling proteins are recruited and regulated ...
Tomlinson, Neil David
core   +7 more sources

Measurement of soluble C-type lectin-like receptor 2 in human plasma [PDF]

Platelets, 2015
Detection of platelet activation in vivo is useful to identify patients at risk of thrombotic diseases. Platelet factor 4 (PF4) and β-thromboglobulin (β-TG) are used for this purpose; however, they are easily released upon the minimal platelet activation that occurs during sampling.
Fuminori, Kazama, Junya, Nakamura, Makoto, Osada, Osamu, Inoue, Mitsuru, Oosawa, Shogo, Tamura, Nagaharu, Tsukiji, Kaoru, Aida, Akio, Kawaguchi, Soichi, Takizawa, Masahiro, Kaneshige, Shoichiro, Tanaka, Katsue, Suzuki-Inoue, Yukio, Ozaki   +13 more
  +10 more sources

Galectin‐9 activates platelet ITAM receptors glycoprotein VI and C‐type lectin‐like receptor‐2 [PDF]

Journal of Thrombosis and Haemostasis, 2022
Platelets are multifunctional cellular mediators in many physiological and pathophysiological processes such as thrombosis, angiogenesis, and inflammation. Several members of galectins, a family of carbohydrate-binding proteins with a broad range of immunomodulatory actions, have been reported to activate platelets.In this study, we investigated the ...
Zhaogong Zhi, Natalie J. Jooss, Yi Sun, Martina Colicchia, Alexandre Slater, Luis A. Moran, Hilaire Yam Fung Cheung, Ying Di, Julie Rayes, Natalie S. Poulter, Steve P. Watson, Asif J. Iqbal   +11 more
openaire   +2 more sources

C‐type lectin‐like CD161 is not a co‐signalling receptor in gluten‐reactive CD4 + T cells [PDF]

Scandinavian Journal of Immunology, 2021
AbstractC‐type lectin‐like CD161, a class II transmembrane protein, is a surface receptor expressed by NK cells and T cells. In coeliac disease, CD161 was expressed more frequently on gluten‐reactive CD4 + T cells compared to other memory CD4 + T cells isolated from the same tissue compartment.
Łukasz Wyrożemski, Ludvig M. Sollid, Shuo‐Wang Qiao   +2 more
openaire   +3 more sources

Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities

Pharmaceutics, 2022
New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic than classical vaccines formulated with live-attenuated or inactivated pathogens.
Diego A. Díaz-Dinamarca, Michelle L. Salazar, Byron N. Castillo, Augusto Manubens, Abel E. Vasquez, Fabián Salazar, María Inés Becker   +6 more
doaj   +1 more source

Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions

Diabetes & Vascular Disease Research, 2020
Background: C-type lectin receptors, including Dectin-2, are pattern recognition receptors on monocytes and macrophages that mainly recognize sugars and sugar-like structures present on fungi.
Kathrin Thiem, Geerte Hoeke, Enchen Zhou, Anneke Hijmans, Tom Houben, Margien G Boels, Isabel M Mol, Esther Lutgens, Ronit Shiri-Sverdlov, Johan Bussink, Thirumala D Kanneganti, Mariëtte R Boon, Rinke Stienstra, Cees J Tack, Patrick CN Rensen, Mihai G Netea, Jimmy FP Berbée, Janna A van Diepen   +17 more
doaj   +1 more source