Results 51 to 60 of about 117,277 (324)
Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets [PDF]
Journal of Biological Chemistry, 2017 Platelets play a key role in the physiological hemostasis or pathological process of thrombosis. Rhodocytin, an agonist of the C-type lectin-like receptor-2 (CLEC-2), elicits powerful platelet activation signals in conjunction with Src family kinases (SFKs), spleen tyrosine kinase (Syk), and phospholipase γ2 (PLCγ2).
Rachit Badolia +5 more
openalex +3 more sources
BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. [PDF]
PLoS Biology, 2007 Dendritic cells are equipped with lectin receptors to sense the extracellular environment and modulate cellular responses. Human plasmacytoid dendritic cells (pDCs) uniquely express blood dendritic cell antigen 2 (BDCA2) protein, a C-type lectin lacking ...
Wei Cao +7 more
doaj +1 more source
The Third Dimension of Reading the Sugar Code by Lectins [PDF]
, 2013 Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
André, Sabine +2 more
core +3 more sources
Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]
, 2002 The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Dvorankova, Barbora +7 more
core +1 more source
Nkrp1 Family, from Lectins to Protein Interacting Molecules
Molecules, 2015 The C-type lectin-like receptors include the Nkrp1 protein family that regulates the activity of natural killer (NK) cells. Rat Nkrp1a was reported to bind monosaccharide moieties in a Ca2+-dependent manner in preference order of GalNac > GlcNAc > ...
Daniel Rozbeský +5 more
doaj +1 more source
Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines
Pathogens, 2022 Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu +2 more
doaj +1 more source
Protein-carbohydrate interactions during fertilization [PDF]
, 1998 Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Kolle, S., Plendl, J., Sinowatz, Fred
core +1 more source
C‐type lectin‐like CD161 is not a co‐signalling receptor in gluten‐reactive CD4 + T cells [PDF]
Scandinavian Journal of Immunology, 2021 AbstractC‐type lectin‐like CD161, a class II transmembrane protein, is a surface receptor expressed by NK cells and T cells. In coeliac disease, CD161 was expressed more frequently on gluten‐reactive CD4 + T cells compared to other memory CD4 + T cells isolated from the same tissue compartment.
Łukasz Wyrożemski +2 more
openaire +3 more sources
Role And Relevance Of Mast Cells In Fungal Infections
Frontiers in Immunology, 2012 In addition to their detrimental role in allergic diseases, mast cells (MCs) are well known to be important cells of the innate immune system. In the last decade, they have been shown to contribute significantly to optimal host defense against numerous ...
Rohit eSaluja +2 more
doaj +1 more source
Innate immunity to Candida albicans
Japanese Dental Science Review, 2015 Candida albicans is not a pathogen in healthy individuals, but can cause severe systemic candidiasis in immunocompromised patients. C. albicans has various virulence factors and activates the innate immune system. Specifically, C.
Yusuke Kiyoura, Riyoko Tamai
doaj +1 more source