Results 31 to 40 of about 38,504 (297)

Integrative analysis workflow for the structural and functional classification of C-type lectins

BMC Bioinformatics, 2011
Background It is important to understand the roles of C-type lectins in the immune system due to their ubiquity and diverse range of functions in animal cells.
Koh Geoffrey, Low Ariana, Poh Daren, Yao Yujian, Ng Say, Wong Victor, Vagenende Vincent, Lam Kong-Peng, Lee Dong-Yup   +8 more
doaj   +1 more source

The Roles of Direct Recognition by Animal Lectins in Antiviral Immunity and Viral Pathogenesis

Molecules, 2015
Lectins are a group of proteins with carbohydrate recognition activity. Lectins are categorized into many families based on their different cellular locations as well as their specificities for a variety of carbohydrate structures due to the features of ...
Yang Liu, Jianying Liu, Xiaojing Pang, Tao Liu, Zhijie Ning, Gong Cheng   +5 more
doaj   +1 more source

Syk-coupled C-type lectins in immunity

Trends in Immunology, 2011
The Syk-coupled C-type lectin receptor Dectin-1 was the first non-Toll like receptor described that could mediate its own intracellular signalling. It was initially identified as important for the innate recognition of and response to fungal pathogens but later studies revealed that it is also involved in triggering adaptive immune responses.
Gordon D. Brown, Ann M. Kerrigan
openaire   +3 more sources

C-type lectins, fungi and Th17 responses

Cytokine & Growth Factor Reviews, 2010
Th17 cells are a recently discovered subset of T helper cells characterised by the release of IL-17, and are thought to be important for mobilization of immune responses against microbial pathogens, but which also contribute to the development of autoimmune diseases.
Maria da Glória Sousa, Simon Vautier, Gordon D. Brown   +2 more
openaire   +3 more sources

Transgenic Expression of Human C-Type Lectin Protein CLEC18A Reduces Dengue Virus Type 2 Infectivity in Aedes aegypti

Frontiers in Immunology, 2021
The C-type lectins, one family of lectins featuring carbohydrate binding domains which participate in a variety of bioprocesses in both humans and mosquitoes, including immune response, are known to target DENV.
Lie Cheng, Lie Cheng, Wei-Liang Liu, Yun-Ting Tsou, Jian-Chiuan Li, Chia-Hao Chien, Matthew P. Su, Kun-Lin Liu, Ya-Lang Huang, Shih-Cheng Wu, Jih-Jin Tsai, Jih-Jin Tsai, Jih-Jin Tsai, Shie-Liang Hsieh, Shie-Liang Hsieh, Shie-Liang Hsieh, Shie-Liang Hsieh, Chun-Hong Chen, Chun-Hong Chen   +18 more
doaj   +1 more source

High Bacterial Agglutination Activity in a Single-CRD C-Type Lectin from Spodoptera exigua (Lepidoptera: Noctuidae)

Biosensors, 2017
Lectins are carbohydrate-interacting proteins that play a pivotal role in multiple physiological and developmental aspects of all organisms. They can specifically interact with different bacterial and viral pathogens through carbohydrate-recognition ...
Leila Gasmi, Juan Ferré, Salvador Herrero   +2 more
doaj   +1 more source

Partial Characterization of Lectins Purified from the Surco and Vara (Furrow and Rod) Varieties of Black Phaseolus vulgaris

Molecules, 2022
As they manifest specifically and reversibly, lectins are proteins or glycoproteins with the characteristic of agglutinating erythrocytes. Given that grain legume lectins can represent 10% of protein content and can have various biological functions ...
Carmen Valadez-Vega, Olivia Lugo-Magaña, Gabriel Betanzos-Cabrera, José Roberto Villagómez-Ibarra   +3 more
doaj   +1 more source

Lectins bring benefits to bones

eLife, 2016
The discovery that proteins called c-type lectins promote bone growth could lead to new treatments for age-related bone disorders.
Charles KF Chan, Ryan C Ransom, Michael T Longaker   +2 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source