Results 1 to 10 of about 71,650 (254)

Rocuronium bromide suppresses esophageal cancer via blocking the secretion of C–X–C motif chemokine ligand 12 from cancer associated fibroblasts [PDF]

Journal of Translational Medicine, 2023
Background Cancer associated fibroblasts (CAFs) communicate metabolically with tumor genesis and development. Rocuronium bromide (RB) is reported to exert certain inhibitory effect on tumor.
Jingyi Li, Xuefeng Gu, Guoqing Wan, Yuhan Wang, Kaijie Chen, Qi Chen, Changlian Lu   +6 more
doaj   +5 more sources

C-X-C motif chemokine ligand 12—C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules [PDF]

Tzu Chi Medical Journal
Chemokines are small, secreted cytokines crucial in the regulation of a variety of cell functions. The binding of chemokine C-X-C motif chemokine ligand 12 (CXCL12) (stromal cell-derived factor 1) to a G-protein-coupled receptor C-X-C chemokine receptor ...
Jui-Hung Yen, Chun-Chun Chang, Hao-Jen Hsu, Chin-Hao Yang, Hemalatha Mani, Je-Wen Liou   +5 more
doaj   +5 more sources

C‑X‑C receptor 7 agonist acts as a C‑X‑C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption. [PDF]

Mol Med Rep, 2022
The C-X-C receptor (CXCR) 7 agonist, VUF11207, is a chemical compound that binds specifically to CXCR7, and negatively regulates C-X-C motif chemokine ligand 12 (CXCL12) and CXCR4-induced cellular events.
Nugraha AP, Kitaura H, Ohori F, Pramusita A, Ogawa S, Noguchi T, Marahleh A, Nara Y, Kinjo R, Mizoguchi I.   +9 more
europepmc   +5 more sources

Collagen content and C-X-C motif chemokine ligand 12 expression in neoplastic breast stroma. [PDF]

Rev Assoc Med Bras (1992), 2023
SUMMARY OBJECTIVE: This study aimed to evaluate the expression of C-X-C motif chemokine ligand 12 and its C-X-C chemokine receptor type 4, and the tumor-stroma ratio using collagen stromal content of breast cancer samples, correlating it with ...
Ferreira CJDS, Caires IQS, Costa Neto WJBD, Almeida SMV.   +3 more
europepmc   +5 more sources

C-X-C motif chemokine ligand 12: a potential therapeutic target in Duchenne muscular dystrophy. [PDF]

Bioengineered, 2021
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused by a mutant dystrophin protein. DMD patients undergo gradual progressive paralysis until death.
Lai X, Chen J.
europepmc   +5 more sources

MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis. [PDF]

Bioengineered, 2022
Endothelial dysfunction is an initial and essential step in vascular-remodeling diseases, including atherosclerosis and neointima formation. During vascular remodeling, activated endothelial cells can release pro-inflammatory factors that promote ...
Yan Y, Zhu M, Ma J, He X, Yang X, Xu H, Jiang M, Zhang S, Duan Y, Han J, Chen Y.   +10 more
europepmc   +4 more sources

MicroRNA-200b-3p restrains gastric cancer cell proliferation, migration, and invasion via C-X-C motif chemokine ligand 12/CXC chemokine receptor 7 axis. [PDF]

Bioengineered, 2022
This study was conducted to investigate the impact of microRNA (miR)-200b-3p on viability, migration, and invasion of gastric cancer (GC) cells and its mechanism.
Li D, Li Q.
europepmc   +4 more sources

Evaluation of the influence of the C-X-C motif chemokine ligand 12 / C-X-C chemokine receptor 4 axis on canine mammary gland tumor cell migration. [PDF]

J Vet Med Sci, 2023
C-X-C motif chemokine ligand 12 (CXCL12) is one of the chemokines that binds to C-X-C chemokine receptor 4 (CXCR4) on tumor cell membranes and induces chemotaxis and/or migration.
Kudo A, Sawahata H, Yoshimoto S, Yamauchi A, Oshita R, Kanai E, Takagi S.   +6 more
europepmc   +4 more sources

MicroRNA‑31 promotes chondrocyte proliferation by targeting C‑X‑C motif chemokine ligand 12. [PDF]

Mol Med Rep, 2019
The present study aimed to investigate the biological function and underlying molecular mechanisms of miR-31 in osteoarthritis (OA). Reverse transcription-quantitative polymerase chain reaction was used to detect miR-31 expression, and it was found that ...
Dai Y, Liu S, Xie X, Ding M, Zhou Q, Zhou X.   +5 more
europepmc   +5 more sources

C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway. [PDF]

Bioengineered, 2022
Esophageal cancer is a malignant tumor of the digestive system that is prone to metastasis. Chemokines and their receptors act an essential role in the occurrence and development of tumors.
Guo J, Tong CY, Shi JG, Li XJ.
europepmc   +4 more sources