Results 51 to 60 of about 17,598 (187)

CCL2 and CXCL12 Derived from Mesenchymal Stromal Cells Cooperatively Polarize IL-10+ Tissue Macrophages to Mitigate Gut Injury

Cell Reports, 2020
Summary: Mesenchymal stromal cell (MSC)-based therapy for inflammatory diseases involves paracrine and efferocytotic activation of immunosuppressive interleukin-10+ (IL-10+) macrophages.
Jayeeta Giri, Rahul Das, Emily Nylen, Raghavan Chinnadurai, Jacques Galipeau   +4 more
doaj   +1 more source

CSF TNF and osteopontin levels correlate with the response to dimethyl fumarate in early multiple sclerosis

Therapeutic Advances in Neurological Disorders, 2022
Background: Disease activity in the first years after a diagnosis of relapsing-remitting multiple sclerosis (RRMS) is a negative prognostic factor for long-term disability.
Damiano Marastoni, Anna I. Pisani, Gianmarco Schiavi, Valentina Mazziotti, Marco Castellaro, Agnese Tamanti, Francesca Bosello, Francesco Crescenzo, Giuseppe K. Ricciardi, Stefania Montemezzi, Francesca B. Pizzini, Massimiliano Calabrese   +11 more
doaj   +1 more source

3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells [PDF]

, 2017
Immunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response.
Bentivegna, Enrico, Bertani, Francesca Romana, Buoncervello, Maria, Businaro, Luca, Canini, Irene, De Ninno, Adele, Falchi, Mario, Fragale, Alessandra, Gabriele, Lucia, Gerardino, Annamaria, Martinelli, Eugenio, Mencattini, Arianna, Molfetta, Rosa, Natale, Corrado, Paolini, Rossella, Parlato, Stefania, Roccazzello, Lorenzo, Romagnoli, Giulia, Salerno, Debora, Toschi, Elena   +19 more
core   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Rho GDP-Dissociation Inhibitor 2 Inhibits C-X-C Chemokine Receptor Type 4-Mediated Acute Lymphoblastic Leukemia Cell Migration

Frontiers in Oncology, 2020
Although we currently have a good understanding of the role C-X-C chemokine receptor type 4 (CXCR4) plays in T cell acute lymphoblastic leukemia (T-ALL), the mechanism of CXCR4-mediated T-ALL migration remains elusive.
Jixian Luo, Junting Wang, Huiguang Zheng, Lan Wang   +3 more
doaj   +1 more source

Macrophage polarization by MSC-derived CXCL12 determines tumor growth

Cellular & Molecular Biology Letters, 2021
Background Phenotypic and functional heterogeneity of macrophages is known to be the main reason for their ability to regulate inflammation and promote tumorigenesis.
Shabnam Babazadeh, Seyed Mahdi Nassiri, Vahid Siavashi, Mohadeseh Sahlabadi, Mostafa Hajinasrollah, Mohamad Zamani-Ahmadmahmudi   +5 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer [PDF]

, 2017
Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator ...
Borzone, Francisco Raúl, Chasseing, Norma Alejandra, Choi, Hosoon, Davies, Kevin Mauro, de Luján Calcagno, María, Feldman, Leonardo, García Rivello, Hernán, Giorello, María Belén, Howard, Scott C., Labovsky, Vivian, Martinez, Leandro Marcelo, Matas, Ayelen, Wernicke, Alejandra   +12 more
core   +2 more sources

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value

Frontiers in Oncology, 2021
Lung cancer is the leading cause of cancer-related death worldwide. Bone metastasis, which usually accompanies severe skeletal-related events, is the most common site for tumor distant dissemination and detected in more than one-third of patients with ...
Xupeng Chai, Xupeng Chai, Eloy Yinwang, Eloy Yinwang, Zenan Wang, Zenan Wang, Zhan Wang, Zhan Wang, Yucheng Xue, Yucheng Xue, Binghao Li, Binghao Li, Hao Zhou, Hao Zhou, Wenkan Zhang, Wenkan Zhang, Shengdong Wang, Shengdong Wang, Yongxing Zhang, Yongxing Zhang, Hengyuan Li, Hengyuan Li, Haochen Mou, Haochen Mou, Lingling Sun, Lingling Sun, Hao Qu, Hao Qu, Fangqian Wang, Fangqian Wang, Zengjie Zhang, Zengjie Zhang, Tao Chen, Tao Chen, Zhaoming Ye, Zhaoming Ye   +35 more
doaj   +1 more source