Results 61 to 70 of about 325,163 (330)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A Game-Theoretical Network Formation Model for C. elegans Neural Network

Frontiers in Computational Neuroscience, 2019
Studying and understanding human brain structures and functions have become one of the most challenging issues in neuroscience today. However, the mammalian nervous system is made up of hundreds of millions of neurons and billions of synapses.
Mohamad Khajezade, Sama Goliaei, Hadi Veisi   +2 more
doaj   +1 more source

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi [PDF]

, 2013
Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for ...
Alan D. Winter, Antony P. Page, Bendtsen, Cox, Ellgaard, Evans, Ghedin, Gillian McCormack, Hotez, Jex, Johanna Myllyharju, John, Kamath, Kelly, Kivirikko, Koivunen, Lamberg, Landmann, Lappi, Lok, Maule, Merriweather, Mitreva, Myllyharju, Myllyharju, Myllyharju, Opperman, Ottesen, Page, Petralanda, Pirneskoski, Rajan, Riihimaa, Stiernagle, Takacs, Timmons, Wang, Winter, Winter, Winter, Winter   +40 more
core   +1 more source

Maintenance of C. elegans [PDF]

WormBook, 1999
Abstract Wild-type and mutant stocks of Caenorhabditis elegans are available from the Caenorhabditis Genetics Center (CGC). C. elegans is easily grown in the laboratory, with stocks routinely maintained on agar-filled Petri plates. However, they can be grown in liquid culture when larger quantities of worms are needed.
openaire   +2 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

An evolutionarily conserved transcriptional response to viral infection in Caenorhabditis nematodes

BMC Genomics, 2017
Background Caenorhabditis elegans is a powerful model organism for probing many biological processes including host-pathogen interactions with bacteria and fungi. The recent identification of nematode viruses that naturally infect C.
Kevin Chen, Carl J. Franz, Hongbing Jiang, Yanfang Jiang, David Wang   +4 more
doaj   +1 more source

Characterization of aminopeptidase encoding gene anp-1 and its association with development in Caenorhabditis elegans [PDF]

PeerJ, 2019
Background Aminopeptidases play important roles in various biological processes in nematodes including growth, development and reproduction. Although the aminopeptidases have been shown to regulate reproduction in Caenorhabditis elegans (C. elegans), the
Shanchun Su, Baoliang Pan, Yanxin Hu, Ming Wang   +3 more
doaj   +2 more sources

Neuronal and non-neuronal signals regulate Caernorhabditis elegans avoidance of contaminated food [PDF]

, 2018
One way in which animals minimise the risk of infection is to reduce their contact with contaminated food. Here we establish a model of pathogen-contaminated food avoidance using the nematode worm Caernorhabditis elegans.
Alexandra Anderson, Brenner S, Darby C, Ewbank JJ, Rachel McMullan, Stiernagle T   +5 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Determinants in the LIN-12/Notch Intracellular Domain That Govern Its Activity and Stability During Caenorhabditis elegans Vulval Development

G3: Genes, Genomes, Genetics, 2016
Upon ligand binding, the LIN-12/Notch intracellular domain is released from its transmembrane tether to function in a nuclear complex that activates transcription of target genes.
Yuting Deng, Iva Greenwald
doaj   +1 more source