Results 71 to 80 of about 19,786,213 (303)
Current Research in Microbial Sciences, 2023 gspd-1-RNAi knockdown Caenorhabditis elegans was used as an immune-compromised model to investigate the role of G6PD in host-pathogen interactions.
Wan-Hua Yang +7 more
doaj +1 more source
Neuropeptide GPCRs in C. elegans [PDF]
Frontiers in Endocrinology, 2012 Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools.
Frooninckx, Lotte +7 more
openaire +3 more sources
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone
Angewandte Chemie, EarlyView.AchC is an ATP‐independent, pH‐responsive chaperone. AchC functions as a molecular switch, sensing pH changes and undergoing a two‐stage conformational transition: C‐terminal extension (colored in yellow) loosening at mild pH 4.0–5.5 and monomerization at strong acidic pH 3.0.
Soojeong Ham +4 more
wiley +2 more sources
Poly-G/poly-C tracts in the genomes of
BMC Genomics, 2007 Background In the genome of Caenorhabditis elegans, homopolymeric poly-G/poly-C tracts (G/C tracts) exist at high frequency and are maintained by the activity of the DOG-1 protein. The frequency and distribution of G/C tracts in the genomes of C. elegans
Rose Ann M, O'Neil Nigel J, Zhao Yang
doaj +1 more source
Selenite enhances immune response against Pseudomonas aeruginosa PA14 via SKN-1 in Caenorhabditis elegans. [PDF]
PLoS ONE, 2014 Selenium (Se) is an important nutrient that carries out many biological processes including maintaining optimal immune function. Here, inorganic selenite (Se(IV)) was evaluated for its pathogen resistance and potential-associated factors in ...
Wen-Hsuan Li +4 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang +13 more
wiley +1 more source
Gait transitions in C. elegans [PDF]
, 2014 textThe ability to switch between different forms of locomotion is critical to many aspects of survival, whether it is switching from walking to running to evade predators, or switching to a slower gait to obtain food.
Topper, Stephen Matthew
core
Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis [PDF]
, 2011 This work was supported by grants from the Wellcome Trust and BBSRC. GRP was supported by a Wellcome Trust Prize Studentship. The C. elegans strain used in this work was provided by the Caenorhabditis Genetics Center, which is funded by the National ...
Haynes, Lee P. +32 more
core +1 more source
qcGEM: A Graph‐Based Molecular Representation With Quantum Chemistry Awareness
Advanced Science, EarlyView.In this work, we introduce qcGEM, a quantum‐chemistry‐aware graph‐based embedding of molecules that incorporates physical priors into molecular representation learning. Through a specially designed model architecture to adequately process quantum chemistry information as well as three‐dimensional molecular geometry, qcGEM provides a compact, physics ...
Haoyu Wang +3 more
wiley +1 more source