Results 61 to 70 of about 18,831,157 (296)

Isolation of specific neurons from C. elegans larvae for gene expression profiling. [PDF]

PLoS ONE, 2014
The simple and well-described structure of the C. elegans nervous system offers an unprecedented opportunity to identify the genetic programs that define the connectivity and function of individual neurons and their circuits.
W Clay Spencer, Rebecca McWhirter, Tyne Miller, Pnina Strasbourger, Owen Thompson, LaDeana W Hillier, Robert H Waterston, David M Miller   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mass Surveilance of C. elegans—Smartphone-Based DIY Microscope and Machine-Learning-Based Approach for Worm Detection

Sensors, 2019
The nematode Caenorhabditis elegans (C. elegans) is often used as an alternative animal model due to several advantages such as morphological changes that can be seen directly under a microscope.
Julia Bornhorst, Eike Jannik Nustede, Sebastian Fudickar   +2 more
doaj   +1 more source

Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae

Current Research in Microbial Sciences, 2023
gspd-1-RNAi knockdown Caenorhabditis elegans was used as an immune-compromised model to investigate the role of G6PD in host-pathogen interactions.
Wan-Hua Yang, Po-Hsiang Chen, Hung-Hsin Chang, Hong Luen Kwok, Arnold Stern, Po-Chi Soo, Jiun-Han Chen, Hung-Chi Yang   +7 more
doaj   +1 more source

Axon regeneration in C. elegans [PDF]

Current Opinion in Neurobiology, 2014
Single axon transection by laser surgery has made Caenorhabditis elegans a new model for axon regeneration. Multiple conserved molecular signaling modules have been discovered through powerful genetic screening. In vivo imaging with single cell and axon resolution has revealed unprecedented cellular dynamics in regenerating axons.
Hammarlund, Marc, Jin, Yishi
openaire   +4 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Poly-G/poly-C tracts in the genomes of Caenorhabditis

BMC Genomics, 2007
Background In the genome of Caenorhabditis elegans, homopolymeric poly-G/poly-C tracts (G/C tracts) exist at high frequency and are maintained by the activity of the DOG-1 protein. The frequency and distribution of G/C tracts in the genomes of C. elegans
Rose Ann M, O'Neil Nigel J, Zhao Yang
doaj   +1 more source

Neuropeptide GPCRs in C. elegans [PDF]

Frontiers in Endocrinology, 2012
Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools.
Frooninckx, Lotte, Van Rompay, Liesbeth, Temmerman, Liesbet, Van Sinay, Elien, Beets, Isabel, Janssen, Tom, Husson, Steven J., Schoofs, Liliane   +7 more
openaire   +3 more sources

Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans [PDF]

, 2012
The C. elegans nervous system is particularly well suited for optogenetic analyses of circuit function: Essentially all connections have been mapped, and light can be directed at the neuron of interest in the freely moving, transparent animals, while ...
Karen Erbguth, Karen Erbguth (129602), Matthias Prigge (129605), Franziska Schneider (129609), Peter Hegemann, Alexander Gottschalk, Hegemann, Peter, Franziska Schneider, Prigge, Matthias, Gottschalk, Alexander, Matthias Prigge, Erbguth, Karen, Alexander Gottschalk (129613), Schneider, Franziska, Peter Hegemann (8931)   +14 more
core   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source