Results 221 to 230 of about 3,095,271 (376)

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Health-related quality of life in hereditary angioedema patients treated with subcutaneous C1 inhibitor (C1-INH) therapy in Canada. [PDF]

Allergy Asthma Clin Immunol
Waserman S, Lacuesta G, Kanani AS, Sussman GL, Kim H, Chapdelaine H, Goubran Messiha HA, Kalicinsky C, Adatia A, Yap B, Dansereau MF, Tanios N, El-Sayegh R, Martin A, Mahfouz H, Machnouk M, Keith PK.   +16 more
europepmc   +1 more source

C1-Inhibitor Decreases the Release of Vasculitis-Like Chemotactic Endothelial Microvesicles.

Journal of the American Society of Nephrology, 2017
Maria Mossberg, Anne-lie Ståhl, R. Kahn, A. Kristoffersson, Ramesh Tati, Caroline Heijl, M. Segelmark, L. M. Leeb-Lundberg, D. Karpman   +8 more
semanticscholar   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Clinical validity of dried blood spot assay for the measurement of functional C1 inhibitor in angioedema due to C1 inhibitor deficiency. [PDF]

J Allergy Clin Immunol Glob
Bernstein JA, Cheng J, Pisani T, Sexton D, Whitaker RE, Nova Estepan D, Inhaber N.   +6 more
europepmc   +1 more source

Hereditary angioedema with normal C1 inhibitor: Four types and counting.

Journal of Allergy and Clinical Immunology, 2018
B. Zuraw
semanticscholar   +1 more source

Clusters of intragenic Alu repeats predispose the human C1 inhibitor locus to deleterious rearrangements.

, 1990
Dominique Stoppa‐Lyonnet, P E Carter, T Meo, Mario Tosi   +3 more
openalex   +2 more sources

Angioedema of the Tongue Due to Acquired C1 Esterase Inhibitor Deficiency [PDF]

, 2003
Gregory Dobson, David Edgar, John Trinder   +2 more
openalex   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Acquired Angioedema Related to Transient C1- Inhibitor Deficiency Triggered by <i>Mycoplasma pneumoniae</i> Infection: A Case Report. [PDF]

Reports (MDPI)
Peristeri AM, Akritidou O, Nikopoulou A, Theodoridou K, Leontakianakos M, Theocharidou CC, Pilianidis G.   +6 more
europepmc   +1 more source