Results 241 to 250 of about 721,729 (294)

Real-world outcomes of patients with hereditary angioedema with normal C1-inhibitor function and patients with idiopathic angioedema of unknown etiology in Canada. [PDF]

Allergy Asthma Clin Immunol
Adatia A, Boursiquot JN, Goodyear D, Kalicinsky C, Kanani A, Waserman S, Nguyen MML, Wadhwa A, Weiss J, El-Zoeiby A, Betschel S.   +10 more
europepmc   +1 more source

Transition Metal‐Free Heteroarene Insertion Into C─C Bonds of Benzocyclobutenones

Angewandte Chemie, EarlyView.
A transition metal‐free insertion of five‐membered heteroarenes into the C─C bonds of benzocyclobutenones has been achieved under mild and operationally simple conditions. This method provides an efficient and modular approach to access fused partially saturated hetero‐polycyclic scaffolds that exist in many bioactive molecules.
Cole J. Wagner, Guangbin Dong
wiley   +1 more source

A real-world study of hereditary angioedema patients due to C1 inhibitor deficiency treated with danazol in the Brazilian Public Health System. [PDF]

Front Med (Lausanne)
Ritter AMV, Silva S, de Paula R, Senra J, Carvalho F, Ribeiro T, Valle SOR.   +6 more
europepmc   +1 more source

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, EarlyView.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration

Angewandte Chemie, EarlyView.
The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti, Hannah Dreisbach, Rémi Corlay, Clara Weber, Tamara Reiter, Wael Elaily, Bastian Daniel, Klaus Zangger, Pedro A. Sánchez‐Murcia, Mélanie Hall   +9 more
wiley   +1 more source

Rare connective tissue diseases in patients with C1-inhibitor deficiency hereditary angioedema: first evidence on prevalence and distribution from a large Italian cohort study. [PDF]

Front Immunol
Triggianese P, Senter R, Perego F, Gidaro A, Petraroli A, Arcoleo F, Brussino L, Giardino F, Rossi O, Bignardi D, Quattrocchi P, Brancaccio R, Cesoni Marcelli A, Accardo PA, Lo Sardo L, Cataudella E, Guarino MD, Firinu D, Bergamini A, Spadaro G, Zanichelli A, Cancian M.   +21 more
europepmc   +1 more source

Reduced Symmetry Metal–Organic Cage‐to‐Framework Materials

Angewandte Chemie, EarlyView.
A series of Ag(I) MOFs was synthesised from organic cages of varying structure and symmetry as linkers. Minor variations in the cage linkers were shown to significantly influence the structures of the resulting MOFs. This work represents the first incorporation of reduced symmetry (including chiral), intrinsically porous building blocks into MOFs, and ...
Cameron J. T. Cox, Aaron H. Bernardino, Louise Male, Rebecca L. Greenaway, Georgia R. F. Orton, James E. M. Lewis   +5 more
wiley   +1 more source

Berotralstat in hereditary angioedema due to C1 inhibitor deficiency: first real-world evidence from a Canadian center. [PDF]

Front Immunol
Srinivasan C, Ritchie B, Adatia A.
europepmc   +1 more source

Association of Endothelial Cell Activation with Acute Kidney Injury during Coronary Angiography and the Influence of Recombinant Human C1 Inhibitor-A Secondary Analysis of a Randomized, Placebo-Controlled, Double-Blind Trial. [PDF]

Biomedicines
Moser S, Araschmid L, Panagiotou A, Bonati LH, Breidthardt T, Fahrni G, Kaiser C, Jeger R, Trendelenburg M, Osthoff M.   +9 more
europepmc   +1 more source

Acute Abdominal Pain as the Initial Presentation of an Acquired C1 Inhibitor Deficiency. [PDF]

GE Port J Gastroenterol
Pinto AR, Carolino F.
europepmc   +1 more source