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Monocyte C1‐inhibitor synthesis in patients with C1‐inhibitor deficiency
Abstract. Monocytes of seven out of eight patients with type 1 C1‐inhibitor (C1‐inh) deficiency (HAE) produced 40% as much C1‐inh as monocytes from normal donors (controls). In contrast, monocytes from three patients with type 2 and three patients with acquired C1‐inh deficiency produced similar amounts of Cl‐inh as controls. Recombinant γ‐interferon (
D F, Lappin +6 more
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Autoantibodies to C1 inhibitor (C1-INH) bind to epitopes on the reactive center of the C1-INH molecule. As a consequence of this binding, C1-INH is converted into an inactive substrate that can be cleaved by proteases. C1-INH is a serine protease inhibitor that plays a role in the complement, contact, fibrinolytic, and coagulation cascades ...
Zanichelli, A +3 more
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Best Practice & Research Clinical Gastroenterology, 2005
Hereditary and acquired deficiencies of the C1 inhibitor result in a single prominent symptom, namely angioedema. Angioedema may involve the skin, the gastrointestinal tract or the upper airway. Genetically determined defects in C1INH cause hereditary angioedema.
Fred S, Rosen, Alvin E, Davis
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Hereditary and acquired deficiencies of the C1 inhibitor result in a single prominent symptom, namely angioedema. Angioedema may involve the skin, the gastrointestinal tract or the upper airway. Genetically determined defects in C1INH cause hereditary angioedema.
Fred S, Rosen, Alvin E, Davis
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BACKGROUND: Administration of C1-inhibitor concentrate is effective for prophylaxis and treatment of severe angioedema attacks caused by C1-inhibitor deficiency.
, C Erik Hack
exaly +2 more sources
Nihon rinsho. Japanese journal of clinical medicine, 2000
Ranol Zahedi, Alvin E. Davis
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Ranol Zahedi, Alvin E. Davis
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C1-inhibitor synthesis by monocytes of patients with C1-inhibitor deficiency
Biochemical Society Transactions, 1987LINDA JONES +3 more
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C1 INHIBITOR IN MALIGNANT DISEASES
The Lancet, 1976P J, Lachmann, J, Wragge-Morley
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