Results 71 to 80 of about 3,095,271 (376)

C1 Inhibitor Deficiency and Angioedema of the Small Intestine Masquerading as Crohn’s Disease

Canadian Journal of Gastroenterology, 2000
A case of C1 inhibitor deficiency presenting as localized edema of the small intestine is described. A 16-year-old, previously healthy woman presented with recurrent attacks of abdominal pain and vomiting following minor abdominal trauma.
Kelly W Burak, Gary R May
doaj   +1 more source

Presence of C1-inhibitor polymers in a subset of patients suffering from hereditary angioedema. [PDF]

PLoS ONE, 2014
Hereditary angioedema (HAE) is a potentially life-threatening disease caused by mutations in the gene encoding the serine protease inhibitor (serpin) C1 inhibitor (C1-inh).
Daniel Elenius Madsen, Søren Hansen, Jørgen Gram, Anette Bygum, Christian Drouet, Johannes Jakobsen Sidelmann   +5 more
doaj   +1 more source

Enzimreakciók vizsgálata a moduláris szerveződés, az atomi kölcsönhatás és a kvantummechanika szintjein. A fehérje biofizika tudományos iskolája = Insight into the Enzyme Action at Levels of modular Organization, Atomic Interactions and Quantum-Mechanics. School of Protein Biophysics [PDF]

, 2009
Az elmúlt 3 év koherens kutató munkája során születtek speciális tudományos eredmények és levontunk ezekből általános következtetéseket is. Munkánk mérlege a nemzetközi folyóiratokban megjelent 30 közlemény összesen 130 IF-al. Molekuláris immunológiai
Barna, László, Beinrohr, László, Borbola, Ildikó, Cseh-Szilágyi, Katalin, Dobó, József, Gyimesi, Gergely, Gál, Péter, Hajdú, István, Juhász, Tünde, Kamondi, Szilárd, Kazinczyné Vas, Mária, Kocsis, Andrea, Major, Balázs, Pollnerné Flachner, Beáta, Sebestyén, Edina, Szavicskó, István, Vonderviszt, Ferenc, Végh, Barbara Márta, Závodszky, Péter   +18 more
core  

Attempts to detect retrotransposition and de novo deletion of Alus and other dispersed repeats at specific loci in the human genome [PDF]

, 2001
Dispersed repeat elements contribute to genome instability by de novo insertion and unequal recombination between repeats. To study the dynamics of these processes, we have developed single DNA molecule approaches to detect de novo insertions at a single
AJ Jeffreys, AJ Jeffreys, AR Jeffs, BF Koop, D Stoppa-Lyonnet, F Rouyer, HH Kazazian, HH: Kazazian, J Murray, J: Jurka, M: Kimura, PE Carter, PL Deininger, Y Miki, Z Wong   +14 more
core   +1 more source

Hereditary angioedema with normal C1 inhibitor in a French cohort: Clinical characteristics and response to treatment with icatibant

Immunity, Inflammation and Disease, 2017
The clinical characteristics and icatibant‐treatment outcomes of patients with hereditary angioedema with normal C1 inhibitor (HAE‐nC1 INH) are limited.
L. Bouillet, I. Boccon-Gibod, D. Launay, A. Gompel, G. Kanny, V. Fabien, O. Fain   +6 more
semanticscholar   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Oxidative stress markers in patients with hereditary angioedema

Archives of Medical Science, 2018
Introduction Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) or with normal C1-INH is characterized by recurrent swellings due to uncontrolled production of vasoactive mediators, among which bradykinin (BK) is crucial. Through the binding and
Stefano R. Del Giacco, Davide Firinu, Paola Lucia Minciullo, Maria Pina Barca, Paolo Emilio Manconi, Gennaro Tartarisco, Mariateresa Cristani, Antonella Saija, Sebastiano Gangemi   +8 more
doaj   +1 more source

Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex

mBio, 2021
Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, a C1 inhibitor (C1-INH), is a key regulator (inhibitor) of serine proteases of all the ...
Arun Dhillon, Justin C. Deme, Emily Furlong, Dorina Roem, Ilse Jongerius, Steven Johnson, Susan M. Lea   +6 more
doaj   +1 more source

Guideline: Hereditary angioedema due to C1 inhibitor deficiency

Allergo Journal International, 2019
S1Guideline of the German Society for Angioedema (Deutsche Gesellschaft für Angioödeme, DGA), German Society for Internal Medicine (Deutsche Gesellschaft für Innere Medizin, DGIM), German Society for Otorhinolaryngology (Deutsche Gesellschaft für Hals ...
K. Bork, E. Aygören‐Pürsün, M. Baş, T. Biedermann, J. Greve, K. Hartmann, M. Magerl, I. Martínez-Saguer, M. Maurer, H. Ott, Lucia Schauf, P. Staubach, B. Wedi   +12 more
semanticscholar   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source