Results 171 to 180 of about 421,380 (247)

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

Discovery of a CHI3L1-targeted small molecule modulating neuroinflammation in Alzheimer's disease <i>via</i> DNA-encoded library (DEL) screening. [PDF]

RSC Med Chem
Kaur B, Zhang L, Nada H, Calvo-Barreiro L, Gabr MT.   +4 more
europepmc   +1 more source

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

Myelin Basic Protein Post-Translational Modifications Orchestrate Astrocyte Regulatory Networks. [PDF]

NeuroSci
Ramsden J, Chikviladze M, Mamulashvili N, Shanshiashvili L, Mikeladze D.   +4 more
europepmc   +1 more source

Selective Conversion of Polyolefin Waste to Branched Alkanes via Methane‐Free Tandem Hydrocracking–Isomerization

Advanced Science, EarlyView.
Scheme illustrating the selective conversion of plastic waste to isomerized C4‐C12 products using RuSZ1 under different reaction conditions. ABSTRACT In recent years, catalytic hydrocracking has emerged as a promising waste‐to‐feedstock solution for processing plastic waste.
Xinbang Wu, Sitan Wang, Matilde Onofri, Kande Liu, Kun‐Han Lin, Roland C. Turnell‐Ritson, Li Shi, Xuan Meng, Paul J. Dyson   +8 more
wiley   +1 more source

Intracranial erosion of an occipitocervical rod through the foramen magnum following occipitocervical fusion for retro-odontoid pannus: illustrative case. [PDF]

J Neurosurg Case Lessons
Gunasekaran A, Horne F, Sheedy M, Saway BF, Sirianni J, Morgan SL, Faulkner AL.   +6 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Episode-wide Maudsley staging in treatment-resistant depression: a longitudinal tertiary-care comparison of dimensional and categorical outcomes. [PDF]

Front Psychiatry
Antoniou A, Pappa S, Dikeos D, Smyrnis N, Mendlevicz J, Serretti A, Cleare A, Ferentinos P.   +7 more
europepmc   +1 more source

C1-Inaktivator [PDF]

, 2019
openaire   +1 more source