Results 41 to 50 of about 421,380 (247)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Degree of Environmental Pollution in Poland – Ranking of the Provinces in 2016

Studia Ekonomiczne i Regionalne, 2019
Subject and purpose of work: The article presents research aimed at creating the ranking of provinces due to the degree of environmental pollution.
Kukuła Karol
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Environmental pollution and economic growth in the European Union countries: A systematic literature review

Economics and Business Review
This study presents a comprehensive analysis of the relationship between economic growth and CO₂ emissions in the European Union, with a particular focus on the Environmental Kuznets Curve (EKC) hypothesis.
Suproń Błażej
doaj   +1 more source

The Influence of Unbalanced Economic Data on Feature Selection and Quality of Classifiers

Folia Oeconomica Stetinensia, 2020
Research background: The successful learning of classifiers depends on the quality of data. Modeling is especially difficult when the data are unbalanced or contain many irrelevant variables. This is the case in many applications.
Kubus Mariusz
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Properties of synthetic graphite from boric acid-added pitch: performance as anode in lithium-ion batteries

SN Applied Sciences, 2021
Synthetic graphite is produced by a heat treatment process using a carbon precursor (pitch, coke), but it is difficult to produce synthetic graphite of high quality due to the high-temperature process (minimum 3000 °C). Elements used as additive to lower
Jin Ung Hwang, Won Jun Ahn, Ji Sun Im, Jong Dae Lee   +3 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

C1–C2 Transarticular Screw with Sublaminar Wiring for Reducible Atlantoaxial Dislocation: Operative Technique and Surgical Nuances

Journal of Spinal Surgery
Transarticular screw provides rigid C1 C2 fixation. It is associated with robust implant construct and high fusion rates. Combining sublaminar wiring provides rigid three point fixation.
T. P. Waseem Ahamed, Ashutosh Kumar, Abhishek Shukla, Vandan Raiyani, Sudhir Bisan Sasapardhi, Kamlesh Singh Bhaisora, Arun Kumar Srivastava, Raj Kumar   +7 more
doaj   +1 more source