Results 251 to 260 of about 61,741 (331)

Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease [PDF]

, 2018
et al,, Jiang, Xuntian, Ory, Daniel S
core   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Is a Clinical Trial With a Non‐Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK

Clinical Pharmacology &Therapeutics, EarlyView.
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Jin Dong, Andrea Moir, Xavier Pepin, Elizabeth Lowe, Sandy Hopkins, Weifeng Tang, Diansong Zhou   +6 more
wiley   +1 more source

C1-inhibitor Deficiency Induces Myositis-like Symptoms Via the Deposition of the Membrane Attack Complex in the Muscle. [PDF]

Intern Med, 2020
Beck G, Yamashita R, Saeki C, Ogawa T, Shimizu M, Mochizuki H.   +5 more
europepmc   +1 more source

A Study of High‐Emission Industries: How Policy, Strategy, and Technology Shape Corporate Social Responsibility Toward Carbon Neutrality

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The extant carbon neutrality (CN) literature largely offers macro‐ or meso‐level analyses, providing limited insights into implementation experiences that could inform granular policymaking and industry strategies. To address this gap, we examine the lived CN experiences of firms in the transportation, energy, manufacturing, and construction ...
Adeel Luqman, Shalini Talwar, Hawazen Almugren, Attila Kurucz, Enrico Battisti   +4 more
wiley   +1 more source

Rapid resolution of erythema marginatum after icatibant in acquired angioedema [PDF]

, 2011
Broesby-Olsen, Sigurd, Bygum, Anette
core   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

A SERPING1 variant that causes C1-inhibitor deficiency without hereditary angioedema

, 2019
Silvia Berra, Chiara Suffritti, Andrea Zanichelli, Debora Parolin, Wu ., Francesca Perego, Marco Cicardi, Sonia Caccia   +7 more
openalex   +1 more source

Advances in Electrocatalytic Valorization of Glycerol: From Fundamental Understanding to Practical Innovation

EcoEnergy, EarlyView.
This review provides a comprehensive overview of recent advances in glycerol electro‐oxidation reaction, covering electrocatalyst design, electrolyte and operating optimization, and mechanistic understanding of reaction pathways. Integrated anodic–cathodic systems and techno‐economic assessments are discussed, followed by key challenges and future ...
Jiamin Wang, Rafael B. Araujo, Hong Liu, Xiaowen Yu   +3 more
wiley   +1 more source

On the molecular mechanisms of konzo and neurolathyrism [PDF]

, 2011
Diasolua Ngudi, Delphin, Kuo, Yu-Haey, Lambein, Fernand, Van Moorhem, Marijke   +3 more
core   +1 more source