Results 91 to 100 of about 70,452 (309)

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients. [PDF]

PLoS ONE, 2018
INTRODUCTION:Complement binding activity of donor-specific HLA antibodies (DSA) has been suggested as a new tool to stratify immunologic risk in kidney transplantation (KT).
Hyeyoung Lee, Eunhee Han, Ae-Ran Choi, Tae Hyun Ban, Byung Ha Chung, Chul Woo Yang, Yeong Jin Choi, Eun-Jee Oh   +7 more
doaj   +1 more source

HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Monocyte to macrophage differentiation is critical to inflammation and resolution of inflammation and can be regulated by high-mobility group box 1 (HMGB1) and HMGB1 plus C1q, respectively. These are 2 evolutionarily old and highly conserved
Tianye Liu, Alec Xiang, Travis Peng, Amanda C. Doran, K. Tracey, B. Barnes, I. Tabas, Myoungsun Son, B. Diamond   +8 more
semanticscholar   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, EarlyView.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair

eLife, 2020
C1q plays a key role as a recognition molecule in the immune system, driving autocatalytic complement cascade activation and acting as an opsonin. We have previously reported a non-immune role of complement C1q modulating the migration and fate of human ...
Francisca Benavente, K. Piltti, M. Hooshmand, Aileen A. Nava, A. Lakatos, Brianna G Feld, Dana A Creasman, P. Gershon, A. Anderson   +8 more
semanticscholar   +1 more source

Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice [PDF]

Scandinavian Journal of Immunology, 2008
AbstractThe complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti‐C1q) have been found in a number of autoimmune and infectious diseases.
P. Kralikova, E. Potlukova
openaire   +3 more sources

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Accepted Article.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify non‐invasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, The LN classification steering committee   +11 more
wiley   +1 more source

Annus Mirabilis - a guide to the 6th European Lupus meeting 3-5 March 2005 [PDF]

, 2005
This article has no ...
Bowman, S.J., Giles, I.P., Ioannou, Y., Isenburg, D.A., Rahman, A.   +4 more
core  

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Brain : a journal of neurology, 2019
See Cunha (doi:10.1093/brain/awz335) for a scientific commentary on this article. Carvalho et al. provide clues to the onset of immune dysregulation underlying early synaptic loss in Alzheimer’s disease and tauopathies, by linking overactivation of ...
Kevin Carvalho, E. Faivre, Marie J Pietrowski, X. Marques, Victoria Gomez-Murcia, Aude Deleau, V. Huin, J. N. Hansen, S. Kozlov, C. Danis, Mariana Temido-Ferreira, J. Coelho, C. Mériaux, S. Eddarkaoui, S. Gras, Mélanie Dumoulin, Lucrezia Cellai, I. Landrieu, Y. Chern, M. Hamdane, L. Buée, A. Boutillier, S. Lévi, A. Halle, Luísa V. Lopes, D. Blum   +25 more
semanticscholar   +1 more source

hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells

Glia, EarlyView.
SCZ astrocytes display an increased pro‐inflammatory profile upon TNF‐α stimulation. Reactive SCZ astrocytes induce microglial‐like cells to assume a dystrophic phenotype. Reactive SCZ astrocytes limit iMGs' synaptoneurosome uptake and migration. ABSTRACT Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ)
Pablo L. Cardozo, Chia‐Yi Lee, Juliana P. S. Lacerda, Júlia S. Fahel, Pablo Trindade, Gabriela Vitória, Leonardo Chicaybam, Rafaela C. Cordeiro, Isaque J. S. de Faria, Nathália C. Silva, Yaovi M. H. Todjro, Joana C. do P. Maciel, Martin H. Bonamino, Luciene B. Vieira, Breno F. Cruz, Rodrigo Nicolato, Kristen J. Brennand, Stevens K. Rehen, Fabíola M. Ribeiro   +18 more
wiley   +1 more source