Results 121 to 130 of about 57,775 (215)
Clinical and Experimental Immunology, 2000 P, Eggleton, A J, Tenner, K B, Reid
openaire +3 more sources
The FEBS Journal, Volume 293, Issue 5, Page 1358-1375, March 2026.Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto +9 more
wiley +1 more source
Frontiers in ImmunologyBackground and AimsSystemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by the development of autoantibodies against multiple antigens, including complement C1q, starter molecule of the classical pathway.
Eylul Tuncer +6 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 5, Page 1459-1477, March 2026.Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver +3 more
wiley +1 more source
Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle +6 more
wiley +1 more source
Long‐term remission of type B insulin resistance syndrome with immunotherapy: A case report
Journal of Diabetes Investigation, Volume 17, Issue 3, Page 542-545, March 2026.ABSTRACT We report long‐term remission in a patient with type B insulin resistance achieved with a combination of immunotherapies. A 55‐year‐old Japanese man presented with nocturnal hypoglycemia and cytopenia. He also had postprandial hyperglycemia due to severe insulin resistance, which was difficult to manage using high‐dose insulin and recombinant ...
Erika Egawa +3 more
wiley +1 more source
C1q nephropathy- unity in diversity.
Journal of renal injury prevention, 2013 Implication for health policy/practice/research/medical educationC1q nephropathy refers to a disorder in which C1q deposits are seen in mesangium on immunofluorescence microscopy and mesangial electron dense deposits on electron microscopy. The diagnosis of C1q nephropathy is based on demonstration of intense C1q (dominant or co-dominant) positivity ...
openaire +2 more sources
Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron +3 more
wiley +1 more source
A Case of Palmoplantar Vesiculobullous Lesions
JEADV Clinical Practice, Volume 5, Issue 1, Page 315-318, March 2026.
Ali Abid +3 more
wiley +1 more source
Anti-C1q antibodies in patients with systemic lupus erythematosus treated by rituximab
Терапевтический архив, 2013 AIM: To determine the time course of changes in the blood levels of antibodies (Ab) to complement component C1q (a-C1q) in patients with systemic lupus erythematosus (SLE) during rituximab (RTM) therapy and the association with organ injuries in SLE ...
M É Tsanian +4 more
doaj