Results 121 to 130 of about 70,452 (309)

Structural and functional characterization of a single-chain form of the recognition domain of complement protein C1q

Frontiers in Immunology, 2016
Complement C1q is a soluble pattern recognition molecule comprising six heterotrimeric subunits assembled from three polypeptide chains (A, B, and C). Each heterotrimer forms a collagen-like stem prolonged by a globular recognition domain.
Christophe eMoreau, Isabelle eBally, Anne eChouquet, Barbara eBottazzi, Berhane eGhebrehiwet, Christine eGaboriaud, Nicole eThielens   +6 more
doaj   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Serum C1q Levels Have Prognostic Value for Sepsis and are Related to the Severity of Sepsis and Organ Damage

Journal of Inflammation Research, 2021
Huan Li, Juanjuan Chen, Yuanhui Hu, Xin Cai, Dongling Tang, Pingan Zhang Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of ChinaCorrespondence: Pingan Zhang Email zhangpingan927@163.comObjective ...
Li H, Chen J, Hu Y, Cai X, Tang D, Zhang P   +5 more
doaj  

Deciphering the fine details of C1 assembly and activation mechanisms: 'mission impossible'?

Frontiers in Immunology, 2014
The classical complement pathway is initiated by the large (~800kDa) and flexible multimeric C1 complex. Its catalytic function is triggered by the hetero-tetramer of proteases C1r2s2, which is associated to the C1q sensing unit, a complex assembly of 18
Christine eGaboriaud, Christine eGaboriaud, Christine eGaboriaud, Wai-Li eLing, Wai-Li eLing, Wai-Li eLing, Nicole M Thielens, Nicole M Thielens, Nicole M Thielens, Isabelle eBally, Isabelle eBally, Isabelle eBally, Véronique eRossi, Véronique eRossi, Véronique eRossi   +14 more
doaj   +1 more source

Impact of Epicatechin Supplementation on Plasma Proteome Profiles in Obese Men and Women—An Exploratory Approach to Sexual Dimorphism

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Purpose Evidence suggests that consuming epicatechin‐rich green tea can increase metabolism in the body, and this metabolic effect might be linked to weight loss in obese subjects. The precise mechanism by which epicatechin influences weight loss is still unclear.
Celso Pereira Batista Sousa‐Filho, Allanis Valon Ferreira, Leo Kei Iwai, Alison Felipe Alencar Chaves, Talita Souza Siqueira, Victoria Silva, Guilherme Ribeiro Romualdo, Rosemari Otton   +7 more
wiley   +1 more source

The Role of Complement in Synaptic Pruning and Neurodegeneration

ImmunoTargets and Therapy, 2021
Angela Gomez-Arboledas,1 Munjal M Acharya,2,3 Andrea J Tenner1,4,5 1Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA; 2Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA,
Gomez-Arboledas A, Acharya MM, Tenner AJ
doaj  

Biomaterial‐Based Emergency Intervention for Secondary Spinal Cord Injury

Small Science, EarlyView.
Emergency intervention using advanced biomaterials targets key pathological mechanisms to block secondary spinal cord injury (SCI) by inhibiting inflammation, reducing excitotoxicity, restoring the blood−spinal cord barrier, and limiting scar formation, which provides significant neural protection and promotes neural regeneration, offering promising ...
Jincheng Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu, Jianxun Ding   +5 more
wiley   +1 more source

High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis [PDF]

, 2017
Background. Anti-C1q antibodies (anti-C1q) have been shown to correlate positively with systemic lupus erythematosus (SLE) nephritis. Several clinical studies indicated a high negative predictive value, suggesting that active lupus nephritis is rarely ...
Frémeaux-Bacchi, Véronique, Honsova, Eva, Jancova, Eva, Lopez-Trascasa, Margarita, Martinez-Ara, Jorge, Moll, Solange, Picazo, Mari Luz, Potlukova, Eliska, Regenass, Stephan, Sadallah, Salima, Schifferli, Jürg, Tesar, Vladimir, Trendelenburg, Marten   +12 more
core  

C1q+ macrophages: passengers or drivers of cancer progression.

Trends in Cancer, 2022
M. Revel, C. Sautès-Fridman, W. Fridman, L. Roumenina   +3 more
semanticscholar   +1 more source

Complement Component C1q: Historical Perspective of a Functionally Versatile, and Structurally Unusual, Serum Protein

Frontiers in Immunology, 2018
Complement component C1q plays an important recognition role in adaptive, and innate, immunity through its ability to interact, via its six globular head regions, with both immunoglobulin and non-immunoglobulin activators of the complement system, and ...
K. Reid
semanticscholar   +1 more source