Results 151 to 160 of about 62,354 (276)

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes [PDF]

, 2012
Atsuhiko T. Naito, Tomokazu S. Sumida, Seitaro Nomura, Mei‐Lan Liu, Tomoaki Higo, Akito Nakagawa, Katsuki Okada, Taku Sakai, Akihito Hashimoto, Yurina Hara, Ippei Shimizu, Weidong Zhu, Haruhiro Toko, Akemi Katada, Hiroshi Akazawa, Toru Oka, Jong‐Kook Lee, Tohru Minamino, Toshio Nagai, Kenneth Walsh, Akira Kikuchi, Misako Matsumoto, Marina Botto, Ichiro Shiojima, Issei Komuro   +24 more
openalex   +1 more source

Impact of Epicatechin Supplementation on Plasma Proteome Profiles in Obese Men and Women—An Exploratory Approach to Sexual Dimorphism

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Purpose Evidence suggests that consuming epicatechin‐rich green tea can increase metabolism in the body, and this metabolic effect might be linked to weight loss in obese subjects. The precise mechanism by which epicatechin influences weight loss is still unclear.
Celso Pereira Batista Sousa‐Filho, Allanis Valon Ferreira, Leo Kei Iwai, Alison Felipe Alencar Chaves, Talita Souza Siqueira, Victoria Silva, Guilherme Ribeiro Romualdo, Rosemari Otton   +7 more
wiley   +1 more source

Elevated Plasma Complement C1Q Measured Subacutely after Traumatic Brain Injury Is Associated with Poor Functional Outcome Independent of Initial Injury Severity

Neurotrauma Reports
Following traumatic brain injury (TBI), secondary processes, including inflammation, contribute significantly to long-term cognitive and functional impairments.
Tracy Butler, Kewei Chen, Abigail Patchell, Xiangling Mao, Dikoma Shungu, Diany Paola Calderon, Jeanne T. Paz, Sudhin A. Shah   +7 more
doaj   +1 more source

Interaction of fibronectin with C1q and collagen [PDF]

, 1985
Kenneth C. Ingham, Ruth Landwehr, Jürgen Engel   +2 more
openalex   +1 more source

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

The ER/Golgi Protein FNDC3B Facilitates Climbing Fibre to Purkinje Cell Synapse Elimination in the Developing Mouse Cerebellum

European Journal of Neuroscience, Volume 63, Issue 2, January 2026.
We investigated the role of fibronectin type III domain containing 3B (FNDC3B) in climbing fiber (CF) to Purkinje cell (PC) synapse elimination during postnatal development of the mouse cerebellum. We performed PC‐specific deletion of FNDC3B by RNAi‐mediated knockdown or PC‐specific conditional knockout in mice and examined CF to PC synapse development
Céline Louise Mercier, Takaki Watanabe, Yuto Okuno, Kyoko Matsuyama, Kyoko Kushibe, Henry Denny, Taisuke Miyazaki, Miwako Yamasaki, Meiko Kawamura, Manabu Abe, Kenji Sakimura, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano   +13 more
wiley   +1 more source

Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL‐2 proteins

The FEBS Journal, Volume 293, Issue 2, Page 549-564, January 2026.
How the structure of HRK, a member of the BCL‐2 protein family, contributes to its function is poorly understood. Functional analysis of HRK mutants reveals that HRK induces apoptosis in a BH3‐domain‐dependent, but transmembrane‐domain‐independent, manner. The transmembrane domain localises HRK to mitochondria, but alone is insufficient.
Louise E. King, Lukas Faber, Ana J. García‐Sáez   +2 more
wiley   +1 more source

Mutations in UMOD Contribute to the Pathogenesis of ADTKD‐UMOD by Influencing the Function of Complement Factor H

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Tubular atrophy and interstitial fibrosis are basic renal pathological changes in autosomal dominant tubulointerstitial kidney disease (ADTKD). Reduced secretion or abnormal structure of uromodulin (UMOD) are recognised pathogenic factors of ADTKD.
Qiuyu Xie, Lufeng Bai, Kunjing Gong, Nan Hu, Yuqing Chen   +4 more
wiley   +1 more source

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Structural Design and Immunogenicity of a Novel Self‐Adjuvanting Mucosal Vaccine Candidate for SARS‐CoV‐2 Expressed in Plants

Plant Biotechnology Journal, Volume 24, Issue 1, Page 284-299, January 2026.
ABSTRACT Mucosal vaccination for COVID‐19 to boost preexisting though insufficient systemic and local/mucosal immunity remains an attractive prospect but there are currently no licensed mucosal vaccines against this infection. Here, using a plant expression system, we developed a novel mucosal vaccine platform for respiratory viruses and demonstrated ...
Mi‐Young Kim, Andy Cano Tran, Ju Kim, Humblenoble Stembridge Ayuk, Adam Sparrow, Lorenzo Bossi, Megan Brown, Emil Joseph Vergara, Kathrin Göritzer, Elisabetta Groppelli, Tae‐Ho Kwon, Julian K. C. Ma, Yong‐Suk Jang, Rajko Reljic   +13 more
wiley   +1 more source