Results 161 to 170 of about 30,787 (208)

Macrophage C1q: characterization of a membrane form of C1q and of multimers of C1q subunits.

The Journal of Immunology, 1987
Abstract It has been shown recently that C1q, a subcomponent of the first component of the classical complement pathway, is synthesized by macrophages and that endogenous C1q is detectable on the macrophage membrane. In this report, we demonstrate that membrane-associated C1q, which contains the A, B, and C chains of C1q ...
H, Martin, H P, Heinz, K, Reske, M, Loos
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RAGE binds C1q and enhances C1q-mediated phagocytosis

Cellular Immunology, 2012
RAGE, the multiligand receptor of the immunoglobulin superfamily of cell surface molecules, is implicated in innate and adaptive immunity. Complement component C1q serves roles in complement activation and antibody-independent opsonization. Using soluble forms of RAGE (sRAGE) and RAGE-expressing cells, we determined that RAGE is a native C1q globular ...
Wanchao, Ma, Vivek, Rai, Barry I, Hudson, Fei, Song, Ann Marie, Schmidt, Gaetano R, Barile   +5 more
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C1Q nephropathy in children

Pediatric Nephrology, 2005
C1q nephropathy (C1qNP) is a peculiar form of glomerulonephritis characterized by mesangial immunoglobulin and complement deposits, predominantly C1q, with no evidence of systemic lupus erythematosus. We describe the incidence, manifestation, histopathologic findings, follow-up, treatment and outcome of C1qNP.
Tanja, Kersnik Levart, Rajko B, Kenda, Mojca, Avgustin Cavić, Dusan, Ferluga, Anastazija, Hvala, Alenka, Vizjak   +5 more
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Antibodies Against C1q

2019
Antibodies to components of the innate immune system are frequently detected in the sera of patients with systemic lupus erythematosus (SLE). Among these are antibodies against various components of the complement system. Antibodies to C1q have drawn particular attention as they have been suggested to be involved in the pathogenesis of lupus nephritis ...
De Leeuw, Karina, Kallenberg, Cees G.M.
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Role of C1q and C1q Receptors in the Pathogenesis of Systemic Lupus Erythematosus

2003
The association between C1q and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE) is well established. Deficiency in C1q is considered to be a strong susceptibility factor and is corroborated by the fact that > or = 92% of the known cases of hereditary deficiency in C1q develop rheumatic disease.
Berhane, Ghebrehiwet, Ellinor I, Peerschke   +1 more
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Isolation and characterization of maerophage‐derived C1q and its similarities to serum C1q

European Journal of Immunology, 1986
AbstractRecently, we have shown that the collagen‐like, Fc‐recognizing subcomponent C1q of the first complement component is synthesized by human, guinea pig and mouse peritoneal macrophages. To test whether macrophages may contribute to the serum pool of C1q, C1q was purified from guinea pig serum and from guinea pig peritoneal macrophage supernatants
U, Rabs, H, Martin, T, Hitschold, M D, Golan, H P, Heinz, M, Loos   +5 more
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C1q solid-phase radioimmunoassay: Binding properties of solid-phase C1q and evidence that C1q-binding IgG complexes in systemic lupus erythematosus are not bound to endogenous C1q

Journal of Immunological Methods, 1984
The binding properties of C1q solid-phase radioimmunoassay (C1q SPRIA) were examined, using heat-aggregated IgG (HAG) as the model of immune complexes (IC). The free, liquid-phase C1q, which was added to the C1q-coated tubes prior to the addition of HAG, had little inhibitory effect on binding of HAG to the solid-phase C1q, suggesting that the solid ...
S, Uwatoko, S, Aotsuka, M, Okawa, Y, Egusa, R, Yokohari, C, Aizawa, K, Suzuki   +6 more
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Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.

The Journal of Immunology, 1990
Abstract We recently described specific binding sites for C1q on human blood platelets. Structural similarities between the amino-terminal of C1q and collagen have suggested that receptors for both molecules on platelets might be the same.
E I, Peerschke, B, Ghebrehiwet
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Isolation and characterization of mouse C1q

Journal of Immunological Methods, 1980
C1q was isolated from mouse serum and ascites fluid by absorption onto human IgG-coated latex beads followed by separation on 3-10% exponential gradient sodium dodecyl sulfate (SDS) polyacrylamide gels. Mouse C1q was also purified by low ionic strength precipitation of mouse serum.
L M, McManus, P K, Nakane
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Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy?

Clinical Nephrology, 2012
Originally described as a proliferative glomerulonephritis, C1q nephropathy is nowadays mostly recognized as a variant of focal segmental glomerulosclerosis or minimal change disease. We describe a 30-year-old male patient with nephrotic range proteinuria. Kidney biopsy demonstrated a membranous nephropathy with predominant staining for C1q.
Deurwaarder, E.S. den, Steenbergen, E., Hoogeveen, E.K., Wetzels, J.F.M.   +3 more
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