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C1q neutralization during epileptogenesis attenuates complement-mediated synaptic elimination and epileptiform activity. [PDF]
Jeong Y +5 more
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Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuroimmune interactions to intercellular communication. [PDF]
Wang R +8 more
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Autoimmunity Reviews, 2008
Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
exaly +3 more sources
Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
exaly +3 more sources
C1q, antibodies and anti-C1q autoantibodies
Molecular Immunology, 2015The complement system has long been known for its role in combating infections. More recently the complement system is becoming increasingly appreciated for its role in processes that range from waste transport, immune tolerance and shaping of the adaptive immune response.
Beurskens, F.J. +2 more
openaire +3 more sources
C1q-binding proteins and C1q receptors
Current Opinion in Immunology, 1999Aggregated or immobilized complement C1q induces cellular responses in many different cell types. C1q-induced cellular responses may be involved in host defense and in protection against autoimmunity because C1q-deficient humans have infectious complications and a very high incidence of autoimmune disease.
A, Nicholson-Weller, L B, Klickstein
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C1q binding and C1q deviation assays using enzyme labelled C1q
Journal of Immunological Methods, 1984Methods for the enzyme labelling of C1q are described. The C1q conjugates have been incorporated into suitably modified C1q deviation and C1q binding assays for circulating immune complexes. These assays show the expected high positivity rate in sera from patients with systemic lupus erythematosus.
G W, Smith, M J, Myles, I J, Simpson
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RAGE binds C1q and enhances C1q-mediated phagocytosis
Cellular Immunology, 2012RAGE, the multiligand receptor of the immunoglobulin superfamily of cell surface molecules, is implicated in innate and adaptive immunity. Complement component C1q serves roles in complement activation and antibody-independent opsonization. Using soluble forms of RAGE (sRAGE) and RAGE-expressing cells, we determined that RAGE is a native C1q globular ...
Wanchao, Ma +5 more
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