Results 191 to 200 of about 58,368 (237)

Antibodies Against C1q

2019
Antibodies to components of the innate immune system are frequently detected in the sera of patients with systemic lupus erythematosus (SLE). Among these are antibodies against various components of the complement system. Antibodies to C1q have drawn particular attention as they have been suggested to be involved in the pathogenesis of lupus nephritis ...
De Leeuw, Karina, Kallenberg, Cees G.M.
openaire   +2 more sources

C1Q nephropathy in children

Pediatric Nephrology, 2005
C1q nephropathy (C1qNP) is a peculiar form of glomerulonephritis characterized by mesangial immunoglobulin and complement deposits, predominantly C1q, with no evidence of systemic lupus erythematosus. We describe the incidence, manifestation, histopathologic findings, follow-up, treatment and outcome of C1qNP.
Tanja, Kersnik Levart, Rajko B, Kenda, Mojca, Avgustin Cavić, Dusan, Ferluga, Anastazija, Hvala, Alenka, Vizjak   +5 more
openaire   +2 more sources

Macrophage C1q: characterization of a membrane form of C1q and of multimers of C1q subunits.

The Journal of Immunology, 1987
Abstract It has been shown recently that C1q, a subcomponent of the first component of the classical complement pathway, is synthesized by macrophages and that endogenous C1q is detectable on the macrophage membrane. In this report, we demonstrate that membrane-associated C1q, which contains the A, B, and C chains of C1q ...
H, Martin, H P, Heinz, K, Reske, M, Loos
openaire   +2 more sources

Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.

The Journal of Immunology, 1990
Abstract We recently described specific binding sites for C1q on human blood platelets. Structural similarities between the amino-terminal of C1q and collagen have suggested that receptors for both molecules on platelets might be the same.
E I, Peerschke, B, Ghebrehiwet
openaire   +2 more sources

Ultrastructure of Human C1q Protein

Nature New Biology, 1972
THE first component (C1) in the complement system may be defined functionally as a macromolecule capable of binding to antigen-antibody complexes and inducing the sequential reactions of this system. C1 consists of three distinct proteins named C1q, C1r and C1s which,in serum, form a macromolecular complex held together by calcium ions1.
S E, Svehag, L, Manhem, B, Bloth
openaire   +2 more sources

A method to differentiate between anti-C1q antibodies and C1q-binding immune complexes using collagenase-digested solid phase C1q

Journal of Immunological Methods, 1991
A method for the detection of circulating immune complexes in the presence of autoantibodies to C1q is described. Solid phase C1q-digestion with bacterial collagenase results in the elimination of the collagen-like region of C1q. Binding of model immune complexes to this modified solid phase C1q is practically unaltered, while reactivity of anti-C1q ...
J E, Menzel, O, Scherak, G, Kolarz, F, Gamerith, U, Youngchaiyud   +4 more
openaire   +2 more sources

C1q

Nihon rinsho. Japanese journal of clinical medicine, 2000
Franz Petry, Michael Loos
openaire   +3 more sources

C1q levels in hereditary angioedema

Journal of Allergy and Clinical Immunology, 1977
In 21 affected members from 4 kindreds with hereditary angioedema, serum C1q levels generally were in the lower part of the normal range, with some values clearly below the lower limit of normal. The serum C1q levels in patients with hereditary angioedema were significantly depressed when compared with those in unaffected family members (p less than 0 ...
openaire   +2 more sources

Classical Complement Pathway Component C1q: Purification of Human C1q, Isolation of C1q Collagen-Like and Globular Head Fragments and Production of Recombinant C1q—Derivatives. Functional Characterization

2013
The classical complement pathway (CCP) activation is a multimolecular complex, composed of three subcomponents namely C1q, C1r, and C1s. C1q is the recognition subunit of this complex and its binding to the specific targets leads to the formation of active C1, which in turn activates the CCP in an immunoglobulin-dependent or -independent manner. C1q is
openaire   +2 more sources

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

Immunity, 2023
Rengong Zhuo, Yun-wu Zhang, Guojun Bu
exaly