Results 151 to 160 of about 30,787 (208)

Herpes simplex virus-1 induces complement-mediated microglial phagocytosis of synapses in murine primary brain cultures and tissues. [PDF]

Cell Commun Signal
Miteva MT, Protto V, Zanzi F, Pastore F, Simone C, Ripoli C, Marcocci ME, Piacentini R, Grassi C, Palamara AT, De Chiara G.   +10 more
europepmc   +1 more source

Complement role in kidney disease: a comprehensive review and therapeutic innovations. [PDF]

BMC Nephrol
Cortez Ferreira B, Matos Silva G, Venda J, Afonso N, Leal R, Cerqueira S, Galvão A, Sá H.   +7 more
europepmc   +1 more source

A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria. [PDF]

Immunity
Opi DH, Longley RJ, Takashima E, Spelman T, Tayipto Y, Schoffer K, Brewster J, Reiling L, Wines BD, Kiniboro B, Siba P, Harbers M, Hogarth M, Tsuboi T, Robinson LJ, Mueller I, Beeson JG.   +16 more
europepmc   +1 more source

Selective fluorination of Fc glycans enhances antibody-mediated effector functions. [PDF]

Proc Natl Acad Sci U S A
Wang X, Gomozkova M, Li S, Banerjee B, Zong G, Missiakas D, Wang LX.   +6 more
europepmc   +1 more source

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Anti-C1q autoantibodies

Autoimmunity Reviews, 2008
Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition.
exaly   +3 more sources

Development of C1q Affinity Chromatography for the Study of C1q–IgG Interactions [PDF]

The Journal of Immunology, 2023
Abstract The classical complement system represents a central effector mechanism of Abs initiated by the binding of C1q to target bound IgG. Human C1q contains six heterotrimeric globular head groups that mediate IgG interaction, resulting in an avidity-driven binding event involving multiple IgG molecules binding a single C1q ...
Michael J E Marshall, Alexander Knaupp, Christian Spick, Ilker Koese, Maria Maier, Mark S Cragg, Florian Cymer, Tilman Schlothauer   +7 more
openaire   +3 more sources

C1q, antibodies and anti-C1q autoantibodies

Molecular Immunology, 2015
The complement system has long been known for its role in combating infections. More recently the complement system is becoming increasingly appreciated for its role in processes that range from waste transport, immune tolerance and shaping of the adaptive immune response.
Beurskens, F.J., Schaarenburg, R.A. van, Trouw, L.A.   +2 more
openaire   +3 more sources

C1q-binding proteins and C1q receptors

Current Opinion in Immunology, 1999
Aggregated or immobilized complement C1q induces cellular responses in many different cell types. C1q-induced cellular responses may be involved in host defense and in protection against autoimmunity because C1q-deficient humans have infectious complications and a very high incidence of autoimmune disease.
A, Nicholson-Weller, L B, Klickstein
openaire   +2 more sources

C1q binding and C1q deviation assays using enzyme labelled C1q

Journal of Immunological Methods, 1984
Methods for the enzyme labelling of C1q are described. The C1q conjugates have been incorporated into suitably modified C1q deviation and C1q binding assays for circulating immune complexes. These assays show the expected high positivity rate in sera from patients with systemic lupus erythematosus.
G W, Smith, M J, Myles, I J, Simpson
openaire   +2 more sources