Results 61 to 70 of about 68,566 (325)

Anti-C1q autoantibodies, novel tests and clinical consequences

Frontiers in Immunology, 2013
Although anti-C1q autoantibodies have been described more than four decades ago a constant stream of papers describing clinical associations or functional consequences highlights that anti-C1q antibodies are still hot and happening.
Michael eMahler, Rosanne evan Schaarenburg, Leendert eTrouw   +2 more
doaj   +1 more source

Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis. [PDF]

, 2018
Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, the biological role of
Feng, Pan, Gao, Erhe, Lau, Wayne Bond, Ma, Xin-Liang, Qin, Zhigang, Sun, Yang, Tan, Yanzhen, Xu, Xuezeng, Yang, Jian, Yi, Dinghua, Yi, Wei, Yu, Shiqiang, Zhang, Zhengbin, Zhao, Dajun   +13 more
core   +2 more sources

The complement system at the embryo implantation site: friend or foe?

Frontiers in Immunology, 2012
An inflammatory-like process and vascular remodeling represent the main changes that occur in decidua in the early phase of pregnancy. These changes are partly induced by trophoblast cells that colonize the decidua and are also contributed by the ...
Roberta eBulla, Fleur eBossi, Francesco eTedesco   +2 more
doaj   +1 more source

Microglia–Astrocyte Communication via C1q Contributes to Orofacial Neuropathic Pain Associated with Infraorbital Nerve Injury

International Journal of Molecular Sciences, 2020
Trigeminal nerve injury causes a distinct time window of glial activation in the trigeminal spinal subnucleus caudalis (Vc), which are involved in the initiation and maintenance phases of orofacial neuropathic pain.
Sayaka Asano, Yoshinori Hayashi, K. Iwata, Akiko Okada-Ogawa, S. Hitomi, Ikuko Shibuta, Y. Imamura, M. Shinoda   +7 more
semanticscholar   +1 more source

Factorization method for difference equations of hypergeometric type on nonuniform lattices [PDF]

, 2001
We study the factorization of the hypergeometric-type difference equation of Nikiforov and Uvarov on nonuniform lattices. An explicit form of the raising and lowering operators is derived and some relevant examples are given.Comment: 21 ...
Askey R, Atakishiyev N M, Atakishiyev N M, Atakishiyev N M, Atakishiyev N M, Atakishiyev N M, Atakishiyev N M, Bangerezako G, Biedenharn L C, Darboux G, Gasper G, Koekoek R, Lorente M, Macfarlane A J, Miller W Jr, Miller W Jr, Nagiyev Sh M, Nikiforov A F, Nikiforov A F, R S Costas-Santos, R Álvarez-Nodarse, Schrödinger E, Schrödinger E, Smirnov Yu F, Smirnov Yu F, Smirnov Yu F, Spiridonov V, Vilenkin N Ja, Álvarez-Nodarse R, Álvarez-Nodarse R, Álvarez-Nodarse R   +30 more
core   +4 more sources

Monocyte expressed macromolecular C1 and C1q receptors as molecular sensors of danger: Implications in SLE.

Frontiers in Immunology, 2014
The ability of circulating blood monocytes to express C1q receptors (cC1qR and gC1qR)synthesize and secrete the classical pathway proteins C1q, C1r and C1s and their regulator, C1-INH is very well established.
Berhane eGhebrehiwet, Kinga K Hosszu, Alisa M Valentino, Yan eJi, Ellinor I.B. Peerschke   +4 more
doaj   +1 more source

Complement complex 1 subunit q‐mediated hepatic stellate cell activation with connective tissue growth factor elevation is a prognostic factor for survival in rat and human chronic liver diseases

Hepatology Communications, 2022
Complement complex 1 subunit q (C1q) has multiple functions, including cell migration, in addition to its traditional complement‐activating effect. Research shows C1q is a ligand for frizzled receptors (FZDs).
Akiko Eguchi, Motoh Iwasa, Ryosuke Sugimoto, Mina Tempaku, Kyoko Yoshikawa, Naohiko Yoshizawa, Davide Povero, Kazushi Sugimoto, Hiroshi Hasegawa, Yoshiyuki Takei, Hayato Nakagawa   +10 more
doaj   +1 more source

Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of antimouse C1q antibodies

Clinical and Experimental Immunology, 2003
SUMMARY Anti-C1q autoantibodies are present in the serum of patients with different autoimmune diseases such as systemic lupus erythematosus (SLE). The occurrence of these autoantibodies correlates with renal involvement. In the present study we examined whether injection of rabbit antimouse C1q antibodies in mice leads to deposition in ...
Leendert A. Trouw, Mohamed R. Daha, C. van Kooten, Marc A. Seelen, Hallgrimur Benediktsson, Jacques M.G.J. Duijs   +5 more
openaire   +4 more sources

C1q as a target molecule to treat human disease: What do mouse studies teach us?

Frontiers in Immunology, 2022
The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz, Kristina Schulz, Marten Trendelenburg, Marten Trendelenburg   +3 more
doaj   +1 more source

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

Frontiers in Immunology, 2020
The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies.
N. S. Laursen, D. Pedersen, H. Gytz, A. Zarantonello, Jens Magnus Bernth Jensen, A. Hansen, S. Thiel, G. Andersen   +7 more
semanticscholar   +1 more source