Results 61 to 70 of about 57,775 (215)

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. [PDF]

, 1993
Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q ...
Morrison, SL, Smith, RI, Tao, MH
core  

Further remarks on the "Smith is Huq" condition [PDF]

, 2014
We compare the 'Smith is Huq' condition (SH) with three commutator conditions in semi-abelian categories: first an apparently weaker condition which arose in joint work with Bourn and turns out to be equivalent with (SH), then an apparently equivalent ...
Martins-Ferreira, Nelson, Van der Linden, Tim   +1 more
core   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

Advanced Science, EarlyView.
Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
wiley   +1 more source

Structural and functional characterization of a single-chain form of the recognition domain of complement protein C1q

Frontiers in Immunology, 2016
Complement C1q is a soluble pattern recognition molecule comprising six heterotrimeric subunits assembled from three polypeptide chains (A, B, and C). Each heterotrimer forms a collagen-like stem prolonged by a globular recognition domain.
Christophe eMoreau, Isabelle eBally, Anne eChouquet, Barbara eBottazzi, Berhane eGhebrehiwet, Christine eGaboriaud, Nicole eThielens   +6 more
doaj   +1 more source

A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy

Scientific Reports, 2021
It was reported that histopathologic lesions are risk factors for the progression of IgA Nephropathy (IgAN). The aim of this study was to investigate the relationships between mesangial deposition of C1q and renal outcomes in IgAN.
Li Tan, Yi Tang, Gaiqin Pei, Zhengxia Zhong, Jiaxing Tan, Ling Zhou, Dongmei Wen, David Sheikh-Hamad, Wei Qin   +8 more
doaj   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of TCE‐secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice

Frontiers in Immunology
Lack of complement factor C1q of the classical pathway results in severely impaired primary antibody responses. This is a paradox because antibodies, especially IgM, are the most efficient activators of the classical pathway and very little specific IgM ...
Anna-Karin E. Palm, Annika Westin, Diyar Ayranci, Birgitta Heyman   +3 more
doaj   +1 more source

MINI-REVIEW: SYSTEMIC LUPUS ERYTHEMATOSUS AND DEFICIENCIES OF EARLY COMPONENTS OF THE COMPLEMENT CLASSICAL PATHWAY

Frontiers in Immunology, 2016
The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
Lourdes eIsaac, Ana Catarina Lunz Macedo
doaj   +1 more source

Mixed QCD-electroweak corrections to Higgs boson production in gluon fusion [PDF]

, 2009
We compute the 3-loop O(\alpha \alpha_s) correction to the Higgs boson production cross section arising from light quarks using an effective theory approach. Our calculation probes the factorization of QCD and electroweak perturbative corrections to this
Anastasiou, Charalampos, Boughezal, Radja, Petriello, Frank   +2 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source