Results 61 to 70 of about 58,368 (237)

Further remarks on the "Smith is Huq" condition [PDF]

open access: yes, 2014
We compare the 'Smith is Huq' condition (SH) with three commutator conditions in semi-abelian categories: first an apparently weaker condition which arose in joint work with Bourn and turns out to be equivalent with (SH), then an apparently equivalent ...
Martins-Ferreira, Nelson   +1 more
core   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

open access: yesAdvanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou   +5 more
wiley   +1 more source

MINI-REVIEW: SYSTEMIC LUPUS ERYTHEMATOSUS AND DEFICIENCIES OF EARLY COMPONENTS OF THE COMPLEMENT CLASSICAL PATHWAY

open access: yesFrontiers in Immunology, 2016
The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
Lourdes eIsaac, Ana Catarina Lunz Macedo
doaj   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

open access: yesAdvanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li   +12 more
wiley   +1 more source

Emerging and novel functions of complement protein C1q

open access: yesFrontiers in Immunology, 2015
Complement protein C1q, the recognition subcomponent of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self and altered-self and modulate the functions of ...
Lubna eKouser   +6 more
doaj   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin   +9 more
wiley   +1 more source

Endogenous complement-activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen in mice

open access: yesFrontiers in Immunology
Lack of complement factor C1q of the classical pathway results in severely impaired primary antibody responses. This is a paradox because antibodies, especially IgM, are the most efficient activators of the classical pathway and very little specific IgM ...
Anna-Karin E. Palm   +3 more
doaj   +1 more source

Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients. [PDF]

open access: yesPLoS ONE, 2018
INTRODUCTION:Complement binding activity of donor-specific HLA antibodies (DSA) has been suggested as a new tool to stratify immunologic risk in kidney transplantation (KT).
Hyeyoung Lee   +7 more
doaj   +1 more source

Nucleon electromagnetic form factors with non-local chiral effective Lagrangian

open access: yes, 2017
The relativistic version of finite-range-regularisation is proposed. The covariant regulator is generated from the nonlocal Lagrangian. This nonlocal interaction is gauge invariant and is applied to study the nucleon electromagnetic form factors at ...
He, Fangcheng, Wang, P.
core   +1 more source

Human C1q Induces Apoptosis in an Ovarian Cancer Cell Line via Tumor Necrosis Factor [PDF]

open access: yes, 2016
Copyright: © 2016 Kaur, Sultan, Murugaiah, Pathan, Alhamlan, Karteris and Kishore. Human C1q is the first recognition subcomponent of the complement classical pathway that plays a vital role in the clearance of immune complexes, pathogens and apoptotic ...
Alhamlan, F   +6 more
core   +1 more source

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