Results 31 to 40 of about 4,044,136 (204)

Substitutions at position 263 within the von Willebrand factor type A domain determine the functionality of complement C2 protein

Frontiers in Immunology, 2022
The complement system is one of the first defense lines protecting from invading pathogens. However, it may turn offensive to the body’s own cells and tissues when deregulated by the presence of rare genetic variants that impair physiological regulation ...
Alicja Kuźniewska, Marcel Thiel, Daria Kowalska, Anna Felberg-Miętka, Patryk Szynkowski, Stanisław Ołdziej, Emilia Arjona, Ilse Jongerius, Ilse Jongerius, Santiago Rodriguez de Córdoba, Marcin Okrój, Aleksandra Urban, Aleksandra Urban   +12 more
doaj   +1 more source

Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b [PDF]

, 2008
Mutations in the protein dysferlin, a member of the ferlin family, lead to limb girdle muscular dystrophy type 2B and Myoshi myopathy. The ferlins are large proteins characterised by multiple C2 domains and a single C-terminal membrane-spanning helix ...
Achanzar, Anderson, Aroul-Selvam, Bansal, Barker, Bashir, Bateman, Berg, Bernatchez, Bravo, Britton, Brunger, Cagliani, Cagliani, Cho, Cornilescu, Couet, Davis, de Luna, Delaglio, DeLano, Doherty, Dosset, Essen, Eugen-Matthias Strehle, Flocco, Glaser, Gouet, Han, Holm, Huang, James D. Watson, Katharine Bushby, Kawabe, Krissinel, Laskowski, Lennon, Letunic, Linge, Linge, Liu, Lu, Matsuda, Matsuda, McNeil, Miyoshi, Muhandiram, Nagashima, Nalefski, Nederveen, Nguyen, Nicholas H. Keep, Ottiger, Paul C. Driscoll, Ponting, Pryank Patel, Richard Harris, Rizo, Roux, Ruckert, Rumaisa Bashir, Somers, Stella M. Geddes, Sutton, Tagawa, Takahashi, Tan, Therrien, Vranken, Yamazaki, Yasunaga   +70 more
core   +1 more source

The molecular basis of ceramide-1-phosphate recognition by C2 domains[S]

Journal of Lipid Research, 2013
Group IVA cytosolic phospholipase A2 (cPLA2α), which harbors an N-terminal lipid binding C2 domain and a C-terminal lipase domain, produces arachidonic acid from the sn-2 position of zwitterionic lipids such as phosphatidylcholine. The C2 domain has been
Katherine E. Ward, Nitin Bhardwaj, Mohsin Vora, Charles E. Chalfant, Hui Lu, Robert V. Stahelin   +5 more
doaj   +1 more source

Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion

Life, 2021
The host cell invasion process of apicomplexan parasites like Toxoplasma gondii is facilitated by sequential exocytosis of the microneme, rhoptry and dense granule organelles. Exocytosis is facilitated by a double C2 domain (DOC2) protein family.
Daniel N. A. Tagoe, Allison A. Drozda, Julia A. Falco, Tyler J. Bechtel, Eranthie Weerapana, Marc-Jan Gubbels   +5 more
doaj   +1 more source

Centriolar Protein C2cd3 Is Required for Craniofacial Development

Frontiers in Cell and Developmental Biology, 2021
The primary cilium is a ubiquitous, microtubule-based cellular organelle. Primary cilia dysfunction results in a group of disorders termed ciliopathies. C2 domain containing 3 centriole elongation regulator (C2cd3), encodes a centriolar protein essential
Ching-Fang Chang, Ching-Fang Chang, Kari M. Brown, Kari M. Brown, Yanfen Yang, Yanfen Yang, Samantha A. Brugmann, Samantha A. Brugmann, Samantha A. Brugmann, Samantha A. Brugmann   +9 more
doaj   +1 more source

Distinctive phosphoinositide- and Ca²⁺-binding properties of normal and cognitive performance–linked variant forms of KIBRA C2 domain [PDF]

, 2018
Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking.
Bagby, S, Crennell, SJ, Harris, G, Ishima, R, Kalli, AC, Kremerskothen, J, Posner, MG, Sansom, MSP, Upadhyay, A   +8 more
core   +2 more sources

Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII

Frontiers in Molecular Biosciences, 2022
At sites of vascular damage, factor VIII (fVIII) is proteolytically activated by thrombin and binds to activated platelet surfaces with activated factor IX (fIXa) to form the intrinsic “tenase” complex. Previous structural and mutational studies of fVIII
Shaun C. Peters, Kenneth C. Childers, Corbin E. Mitchell, Nathan G. Avery, Steven S. Reese, Cristopher Mitchell, Serena W. Wo, Christopher D. Swanson, Caileen M. Brison, P. Clint Spiegel   +9 more
doaj   +1 more source

Crystal structures of the human Dysferlin inner DysF domain [PDF]

, 2014
Background: Mutations in dysferlin, the first protein linked with the cell membrane repair mechanism, causes a group of muscular dystrophies called dysferlinopathies.
Cole, Ambrose R., Keep, Nicholas H., Orengo, C., Sula, Altin, Yeats, C.   +4 more
core   +1 more source

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module.

Molecules and Cells, 2018
Class II phosphoinositide 3-kinases (PI3K-C2) are large multidomain enzymes that control cellular functions ranging from membrane dynamics to cell signaling via synthesis of 3'-phosphorylated phosphoinositides. Activity of the alpha isoform (PI3K-C2α) is
Haibin Wang, Wen-Ting Lo, A. Vujičić Žagar, F. Gulluni, Martin Lehmann, L. Scapozza, V. Haucke, O. Vadas   +7 more
semanticscholar   +1 more source

Transmembrane Membrane Readers form a Novel Class of Proteins That Include Peripheral Phosphoinositide Recognition Domains and Viral Spikes

Membranes, 2022
Membrane proteins are broadly classified as transmembrane (TM) or peripheral, with functions that pertain to only a single bilayer at a given time. Here, we explicate a class of proteins that contain both transmembrane and peripheral domains, which we ...
Michael Overduin, Anh Tran, Dominic M. Eekels, Finn Overduin, Troy A. Kervin   +4 more
doaj   +1 more source