Results 231 to 240 of about 2,660,664 (273)

Immune podocyte injury in autoimmune glomerular diseases. [PDF]

Front Immunol
Zhu H, Sun J, Yan Y, Liu P, Huang Y.
europepmc   +1 more source

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C3a(desArg) does not bind to and signal through the human C3a receptor

Immunology Letters, 1999
Contradictory results have been published in the past regarding the functional responses of different cell types to the anaphylatoxin C3a and its natural catabolite C3a(desArg). To elucidate the interaction of the C3a receptor (C3aR) with its ligand(s) we studied the binding of human recombinant C3a (rC3a) and rC3a(desArg) to RBL-2H3 transfectants ...
Thomas Werfel
exaly   +3 more sources

The Role of Complement C3a Receptor in Stroke

NeuroMolecular Medicine, 2019
The complement system is a key regulator of the innate immune response against diseased tissue that functions across multiple organ systems. Dysregulation of complement contributes to the pathogenesis of a number of neurological diseases including stroke.
Saif Ahmad, Kanchan Bhatia, Adam Kindelin, Andrew F. Ducruet   +3 more
openaire   +3 more sources

Evidence that the receptor for C4a is distinct from the C3a receptor

Immunopharmacology, 1997
The cDNAs encoding the human (hC3aR) and mouse C3a receptors (mC3aR) were functionally expressed in RBL-2H3 cells. A calcium mobilization assay was utilized to assess the biologic activity of human anaphylatoxins, and C3a synthetic peptide agonists on hC3aR and mC3aR cells and this activity was compared to the activity of the anaphylatoxins on human ...
R S, Ames, M A, Tornetta, J J, Foley, T E, Hugli, H M, Sarau   +4 more
exaly   +3 more sources

Potent Heterocyclic Ligands for Human Complement C3a Receptor

Journal of Medicinal Chemistry, 2014
The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases. A flexible compound (N2-[(2,2-diphenylethoxy)acetyl]-l-arginine, 4), known as a weak C3aR antagonist (IC50 μM), was transformed here into potent agonists (EC50 nM) of human macrophages (Ca(2 ...
Reid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Lim, Junxian, Stoermer, Martin J., Fairlie, David P.   +6 more
openaire   +5 more sources

High Levels of Complement C3a Receptor in the Glomeruli in Lupus Nephritis

American Journal of Kidney Diseases, 2007
Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states.Several antibodies were generated and used for immunohistochemistry and Western blot ...
Masashi Mizuno, Philippe Gasque
exaly   +3 more sources

Inhibition of the C3a receptor attenuates sepsis-induced acute lung injury by suppressing pyroptosis of the pulmonary vascular endothelial cells.

Free Radical Biology & Medicine, 2022
Acute lung injury (ALI) is the leading cause of bacterial sepsis-related death because of disrupted pulmonary endothelial barrier, resulting in protein-rich pulmonary oedema, an influx of pro-inflammatory cells and refractory hypoxaemia.
Zhanjun Li, Yuchang Wang, Quanrui Feng, Yang Zhuang, Zhen-Xing Xie   +4 more
semanticscholar   +1 more source

The Complement C3a–C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma

Anticancer Research, 2022
Background: We aimed to clarify the role of complement C3a and its receptor C3aR in progression of pancreatic ductal adenocarcinoma (PDAC). Materials and Methods: We evaluated the serum levels of C3 and C3a in patients with PDAC.
R. Suzuki, Y. Okubo, T. Takagi, M. Sugimoto, Yuki Sato, Hiroki Irie, Jun Nakamura, Mika Takasumi, T. Kato, M. Hashimoto, Ryouichiro Kobashi, T. Hikichi, H. Ohira   +12 more
semanticscholar   +1 more source

Ligands for C3a and C5a Receptors [PDF]

, 2023
Prolonged activation of the complement system of blood proteins in response to infection or tissue injury can lead to inflammatory diseases. This thesis investigates the potency, selectivity and structures of reported and rationally designed new ligands for human complement receptors C3aR and C5aR, towards development of new therapeutic agents. Chapter
openaire   +1 more source

Pharmacological activity of C3a and C3a receptor ligands

2023
The complement system is an integral component of the innate immune response to infection and injury. The anaphylatoxins, C3a and C5a, are produced upon activation of the classical, alternative or mannan-binding lectin complement pathways. C5a is a potent pro-inflammatory mediator and overactivation or underegulation of C5a is implicated in the ...
openaire   +2 more sources