Results 241 to 250 of about 2,660,664 (273)

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a

European Journal of Pharmacology, 2014
The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury.
William J Branchett, Chris A Kieslich, Daniel E Croker   +2 more
exaly   +2 more sources

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Cloning and Characterization of Rat C3a Receptor: Differential Expression of Rat C3a and C5a Receptors by LPS Stimulation

Biochemical and Biophysical Research Communications, 1998
The anaphylatoxin C3a, generated during complement activation, is a factor known to mediate various inflammatory reactions. The human C3a receptor (C3aR) was recently cloned and identified to be a member of the G-protein-coupled receptor family. C3aR is characterized by seven transmembrane domains including a large second extracellular loop that ...
Y, Fukuoka, J A, Ember, T E, Hugli
openaire   +2 more sources

Autoantibody-Mediated Complement C3a Receptor Activation Contributes to the Pathogenesis of Preeclampsia

Hypertension, 2012
Preeclampsia (PE) is a prevalent life-threatening hypertensive disorder of pregnancy associated with increased complement activation. However, the causative factors and pathogenic role of increased complement activation in PE are largely unidentified ...
Sean C Blackwell, Rodney E Kellems
exaly   +2 more sources

Protection of hUC-MSCs against Neuronal Complement C3a Receptor-mediated NLRP3 Activation in CUMS-induced Mice.

Neuroscience Letters, 2020
BACKGROUND Hyperactivation of complement C3 and inflammation-related activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome are implicated in the etiology of stress-related disorders.
Jing Li, Shujuan Tian, Hua-long Wang, Yanyong Wang, Chongbo Du, Jiyu Fang, Xiaoxiao Wang, Yufeng Wang, Zhexuan Gong, Baoyong Yan, Mingwei Wang   +10 more
semanticscholar   +1 more source

C3a receptor on dibutyryl-cAMP-differentiated U937 cells and human neutrophils: The human C3a receptor characterized by functional responses and 125I-C3a binding

Biochemistry, 1992
The anaphylatoxic peptide C3a is part of a basic immunological defense mechanism, the complement system. Research on the human C3a receptor and signal transduction is hampered by the lack of a suitable human cell or cell line. We screened tumor cell lines and human blood cells for a C3a-dependent increase in cytosolic Ca2+ ([Ca2+]i) and analyzed this ...
A, Klos, S, Bank, C, Gietz, W, Bautsch, J, Köhl, M, Burg, T, Kretzschmar   +6 more
openaire   +2 more sources

Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3&bgr; signaling pathways

European Journal of Pharmacology, 2019
Neurofibrillary tangles aggregated from hyperphosphorylated tau protein are the main pathological feature of Alzheimer's disease (AD). Complement C3 (or C3a) is the core component of the complement system and is associated with AD pathological processes.
Junjie Hu, Yang Yang, Minli Wang, Yi Yao, Yanmin Chang, Quanwei He, Rong Ma, Gang Li   +7 more
semanticscholar   +1 more source

Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells

Glia, 1999
Little is known about the expression of the receptor for complement anaphylatoxin C3a (C3aR) in the central nervous system (CNS). In this study, we provide the first evidence that neurons are the predominant cell type expressing C3aR in the normal CNS.
N, Davoust, J, Jones, P F, Stahel, R S, Ames, S R, Barnum   +4 more
openaire   +2 more sources

Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance

Molecular Immunology, 2018
HighlightsComplement C3aR is expressed on the apical ventricular zone in the developing mouse brain.Pharmacological stimulation of C3aR reduces the proliferation of neural progenitor cells.C3aR‐/‐ mice have impaired recall memory in cognitive testing ...
Liam G. Coulthard, Owen A. Hawksworth, Jacinta N. Conroy, John D. Lee, T. Woodruff   +4 more
semanticscholar   +1 more source

A role for the C3a anaphylatoxin receptor in the effector phase of asthma

Nature, 2000
Asthma is a chronic inflammatory disease of the airways and lung mucosa with a strong correlation to atopy and acquired (IgE) immunity. However, many features of bronchial asthma, such as smooth muscle contraction, mucus secretion and recruitment of inflammatory cells, are consistent with the actions of complement anaphylatoxins, in particular C3a and ...
A A, Humbles, B, Lu, C A, Nilsson, C, Lilly, E, Israel, Y, Fujiwara, N P, Gerard, C, Gerard   +7 more
openaire   +2 more sources

Cellular receptors to the anaphylatoxins C3a and C5a.

Biochemical Society symposium, 1987
A single component in the plasma membrane of human polymorphonuclear leukocytes (hPMN) has been identified as the binding site for C5a. Labelled human C5a can be cross-linked to a 48,000-Mr membrane component on the hPMN surface by using the bifunctional reagent ethylene glycol bis(succinimidyl succinate).
R, Huey, Y, Fukuoka, P D, Hoeprich, T E, Hugli   +3 more
openaire   +1 more source