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The C3a receptor antagonist SB 290157 has agonist activity
Immunology Letters, 2005The anaphylatoxin C3a is an important immune regulator with a number of distinct functions in both innate and adaptive immunity. Many of these roles have been ascribed to C3a based on studies in mice genetically modified to lack its precursor, C3, or its receptor, C3aR.
Marie-Claude, Mathieu +10 more
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Minor role of the C3a receptor in systemic anaphylaxis in the guinea pig
Immunopharmacology, 2000Previously, Regal et al. [Regal, J.F., Fraser, D.G., Toth, C.A., 1993. Role of the complement system in antigen-induced bronchoconstriction and changes in blood pressure in the guinea pig. J. Pharmacol. Exp. Ther. 267, 979-988] demonstrated that preventing complement system activation resulted in inhibition of anaphylaxis in the guinea pig, and that ...
J F, Regal, A, Klos
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Expression of Receptors for Anaphylatoxins C3a and C5a on Rat Islet Preparations
Transplantation Proceedings, 2011Complement activation has been implicated in the development of the instant blood-mediated inflammatory reaction (IBMIR). In particular, anaphylatoxins C3a and C5a elicit a broad range of proinflammatory effects, including chemotaxis of inflammatory cells and cytokine release.
K, Tokodai +5 more
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Genomic organization of the human C3a-receptor (C3aR)
Immunology Letters, 1997D. Paral +5 more
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C3a Receptor Antagonist Attenuates Brain Injury after Intracerebral Hemorrhage
Journal of Cerebral Blood Flow and Metabolism, 2009Brad E Zachariä +2 more
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