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Defective engraftment of C3aR−/− hematopoietic stem progenitor cells shows a novel role of the C3a–C3aR axis in bone marrow homing [PDF]

Leukemia, 2009
We reported that complement (C) becomes activated and cleaved in bone marrow during preconditioning for hematopoietic transplantation and the third C component (C3) cleavage fragments, C3a and (desArg)C3a, increase responsiveness of hematopoietic stem/progenitor cells (HSPCs) to stromal-derived factor-1 (SDF-1).
M Wysoczynski, R Reca, J Ratajczak
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Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins

Nature Chemical Biology, 2023
The complement receptors C3aR and C5aR1, whose signaling is selectively activated by anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune responses. Dysregulations of C3aR and C5aR1 signaling lead to multiple inflammatory disorders, including sepsis, asthma and acute respiratory distress syndrome.
Yue Wang, Weiyi Liu, Youwei Xu, Xinheng He, Qingning Yuan, Ping Luo, Wenjia Fan, Jingpeng Zhu, Xinyue Zhang, Xi Cheng, Yi Jiang, H. Eric Xu, Youwen Zhuang   +12 more
openaire   +2 more sources

Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma

Journal of Allergy and Clinical Immunology, 2005
The mechanisms leading to death from asthma are not completely understood. Recent studies suggest the involvement of the anaphylatoxins C3a and C5a, generated during complement activation, and their receptors C3aR and C5aR in the pathogenesis of asthma.The aim of our study was to investigate the expression of C3aR and C5aR in fatal asthma.We analyzed ...
Annemarie Van Schadewijk, Marisa Dolhnikoff, Mohamed R Daha   +2 more
exaly   +4 more sources

Vibrational predissociation in the bending levels of the à state of C3Ar

The Journal of Chemical Physics, 2020
Vibrational predissociation (VP) has been observed in 16 bands of the C3Ar van der Waals complex near the 0 v2 0 – 000 (v2 = 2−, 4−, 2+) and 0 2− 2 − 100 bands of the Ã1Π–X̃1Σ+g system of C3. New higher resolution wavelength-resolved emission (WRE) spectra covering a wider spectral range have been recorded for many of these C3Ar bands, which show that
Yi-Jen Wang, Yen-Chu Hsu
openaire   +2 more sources

Complement component C3aR constitutes a novel regulator for chick eye morphogenesis

Developmental Biology, 2017
Complement components have been implicated in a wide variety of functions including neurogenesis, proliferation, cell migration, differentiation, cancer, and more recently early development and regeneration. Following our initial observations indicating that C3a/C3aR signaling induces chick retina regeneration, we analyzed its role in chick eye ...
Erika Grajales-Esquivel, Agustin Luz-Madrigal, Edimara S Reis   +2 more
exaly   +3 more sources

Discovery of new C3aR ligands. Part 1: Arginine derivatives

Bioorganic & Medicinal Chemistry Letters, 2007
The synthesis and in vitro binding of several new arginine-containing C3aR ligands are reported. DMPK properties and functional activities of selected compounds have been evaluated. One compound is shown to be active in an in vivo model of airway inflammation after aerosol administration.
Frédéric, Denonne, Sophie, Binet, Maggi, Burton, Philippe, Collart, Alan, Dipesa, Tanmoy, Ganguly, Alexander, Giannaras, Seema, Kumar, Timothy, Lewis, Florence, Maounis, Jean-Marie, Nicolas, Tamsin, Mansley, Patrick, Pasau, Dorin, Preda, Karin, Stebbins, Alexander, Volosov, Dong, Zou   +16 more
openaire   +2 more sources

Illumination of the complement receptors C3aR and C5aR signaling by anaphylatoxins

2023
The complement receptors C3aR and C5aR, whose signaling are selectively activated by anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune responses. Dysregulations of C3aR and C5aR signaling lead to multiple inflammatory disorders, including sepsis, asthma, and acute respiratory distress syndrome (ARDS). The mechanism
Yue Wang, Weiyi Liu, Youwei Xu, Qingning Yuan, Xinheng He, Ping Luo, Wenjia Fan, Jinpeng Zhu, Xinyue Zhang, Xi Cheng, Yi Jiang, H. Eric Xu, Youwen Zhuang   +12 more
openaire   +1 more source

Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives

Bioorganic & Medicinal Chemistry Letters, 2007
The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.
Frédéric, Denonne, Sophie, Binet, Maggi, Burton, Philippe, Collart, Sabine, Defays, Alan, Dipesa, Maria, Eckert, Alexander, Giannaras, Seema, Kumar, Beth, Levine, Jean-Marie, Nicolas, Patrick, Pasau, Cécile, Pégurier, Dorin, Preda, Nathalie, Van houtvin, Andrew, Volosov, Dong, Zou   +16 more
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Characterising Novel and Potent Modulators of Complement Receptor C3aR

2016
In drug design and development, protein ligands are potent and selective for their endogenous receptors in nature but exhibit several disadvantages. Protein ligands are unfavourable drug candidates as they are usually susceptible to enzyme degradation, difficult to synthesise and expensive to manufacture.
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Defective Engraftment of HSPC from C3aR−/ − Mice Reveals an Underappreciated Role of C3a-C3aR Axis in Stem Cell Homing to Bone Marrow.

Blood, 2005
Abstract Recently we demonstrated that complement (C) is activated in bone marrow (BM) during conditioning for transplantation and hematopoietic stem/progenitor cells (HSPC) express on their surface the C3a receptor (C3aR) and in the presence of the third C component - C3 cleavage fragments (C3a and desArgC3a) respond more robustly to a ...
Ryan Reca, Magda Kucia, Jarek Baran, Janina Ratajczak, Mariusz Z. Ratajczak   +4 more
openaire   +1 more source