Results 271 to 280 of about 1,192,546 (345)

Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo. [PDF]

open access: yesNucleic Acids Res
O'Reilly D   +16 more
europepmc   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

open access: yesAdvanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen   +15 more
wiley   +1 more source

Electronic Modulation of K⁺‐Intercalated Polymeric Carbon Nitride via ─C≡N/─OH Functionalization for Efficient Photocatalytic H2O2 Production

open access: yesAdvanced Science, EarlyView.
K+ is successfully embedded in the PCN interlayers via a high‐temperature polymerization. The incorporation of K+ perturbs the local electronic structure via interaction with nitrogen lone pairs, narrowing the PCN bandgap, which exhibits superior photocatalytic performance, achieving a high H2O2 generation rate both in situ and under sunlight ...
Qingquan Xue   +8 more
wiley   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

open access: yesAdvanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin   +16 more
wiley   +1 more source

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