Results 41 to 50 of about 9,499 (196)

Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts

Chinese Medical Journal, 2021
. Background:. The complement system plays an important role in the immune response to transplantation, and the diagnostic significance of peritubular capillary (PTC) C4d deposition (C4d+) in grafts is controversial.
Jin Zheng, Hui Guo, Hui-Lin Gong, Ping Lan, Chen-Guang Ding, Yang Li, Xiao-Ming Ding, Wu-Jun Xue, Yuan-Yuan Ji   +8 more
doaj   +1 more source

Significance of C4d expression in peritubular capillaries concurrent with microvascular inflammation in for-cause biopsies of ABO-incompatible renal allografts [PDF]

Kidney Research and Clinical Practice
Background Pathologic diagnosis of antibody-mediated rejection (ABMR) in ABO-incompatible (ABOi) transplantation patients is often challenging because patients without ABMR are frequently immunopositive for C4d.
Haeyon Cho, Chung Hee Baek, Su-Kil Park, Hyosang Kim, Heounjeong Go   +4 more
doaj   +1 more source

Prognostic Value of C4d Immunolabelling in Adult Patients With IgA Vasculitis

Frontiers in Medicine, 2021
Background and Objectives: Glomerular C4d deposits are associated the severity and outcomes of IgA nephropathy. Whether this holds true in immunoglobulin A vasculitis (IgAV) is not known.
Anais Romero, Fanny Drieux, Arnaud François, Alexandra Dervaux, Xiao Li Xu, Dimitri Titeca-Beauport, Dominique Bertrand, Dominique Guerrot, Dominique Guerrot   +8 more
doaj   +1 more source

Immunohistochemical evaluation of C4d and C3d markers in bullous pemphigoid as a substitute for direct immunofluorescence technique

Indian Journal of Dermatology, 2023
Background: There are several methods for the diagnosis of autoimmune bullous disease. Direct immunofluorescent (DIF) testing is an important diagnostic method in the diagnosis of immunobullous disease but requires skilled pathologist, fresh tissue and ...
Mahsa Akbari Oryani, Naser Tayebi-Meybodi, Yalda Nahidi, Mohsen Soltani Sabi, Monavar Afzal Aghaei   +4 more
doaj   +1 more source

Diagnostic Utility of C4d by Direct Immunofluorescence in Bullous Pemphigoid [PDF]

, 2020
: Bullous pemphigoid (BP) is an autoimmune blistering disease that commonly affects elderly patients. Direct immunofluorescence (DIF) for immunoglobulin G (IgG) and C3c on frozen skin biopsies is the gold standard for the diagnosis of BP.
van Doorn, Martijn B, van Doorn, Martijn B., Barbara Horvath, Martijn B. van Doorn, Diercks, Gilles F H; id_orcid, Jeffrey Damman, Diercks, Gilles F H, Horvath, Barbara, Horvath, Barbara; id_orcid, Gareth Edwards, Damman, Jeffrey, Diercks, Gilles F.H., Edwards, Gareth, Gilles F. H. Diercks   +13 more
core   +2 more sources

Glomerular C4d Deposition and Kidney Disease Progression in IgA Nephropathy: A Systematic Review and Meta-analysisPlain-Language Summary

Kidney Medicine, 2021
Background: Glomerular deposition of C4d is a widely used biomarker for activation of the lectin pathway in the complement system and is reported to be associated with kidney progression in immunoglobulin A nephropathy (IgAN).
Yuanyuan Jiang, Jincan Zan, Sufang Shi, Wanyin Hou, Wenjing Zhao, Xuhui Zhong, Xujie Zhou, Jicheng Lv, Hong Zhang   +8 more
doaj   +1 more source

The diagnostic value of immunohistochemical staining of the interstitial vascular C4d complement in membranous nephropathy

Current Issues in Pharmacy and Medical Sciences, 2021
Membranous glomerulonephritis (MGN) is the most common cause of adulthood nephrotic syndrome. Diagnosis of membranous nephritis is based on light electron immunofluorescence microscopy and clinical signs.
Pourlak Tala, Sharifi Sonya, Vahed Sepideh Zununi, Ahmadian Elham, Cucchiarini Magali   +4 more
doaj   +1 more source

The utility of glomerular C4d immunostaining in renal biopsies in patients with immunoglobulin A nephropathy. A clinicopathological study

, 2017
The course of IgA nephropathy (IgAN) is highly variable and ranges from a totally benign condition to end-stage renal disease in approximately one third of cases.
Małgorzata Wągrowska-Danilewicz, Marian Danilewicz   +1 more
core   +1 more source

C4d expression in cancer patients

, 2014
Das Komplementsystem, mit seinen diversen Pathways, zählt zu den wichtigsten Effektormechanismen der humoralen und angeborenen Immunität. Aufgrund dieser eminenten Rolle und der dargelegten Ergebnisse anderer Arbeitsgruppen bezüglich Komplement, seiner ...
Kodnar, Julia
core   +2 more sources

Noninvasive and quantitative measurement of C4d deposition for the diagnosis of antibody-mediated cardiac allograft rejectionResearch in context

EBioMedicine, 2018
Background: C4d is a specific biomarker for the diagnosis of antibody-mediated rejection (AMR) after cardiac transplantation. Although strongly recommended, routine C4d surveillance is hindered by the invasive nature of endomyocardial biopsy.
Tao Liao, Xiaonan Liu, Jie Ren, Hongjun Zhang, Haofeng Zheng, Xiujie Li, Yannan Zhang, Fei Han, Tinghui Yin, Qiquan Sun   +9 more
doaj   +1 more source