Results 91 to 100 of about 256,837 (255)

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Symmetry‐Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies

Advanced Science, EarlyView.
A unified group‐theory selection rule governs the excitation of vectorial nearfield topologies across three plasmonic spin states. Derived from first principles, it predicts spin–orbit vortex splitting and multidimensional nested vortices, confirmed by phase‐resolved in situ measurements.
Jie Yang, Pengyi Feng, Fei Han, Weijin Chen, Zhongwei Jin, Jincheng Ni, Yuanjie Yang, Anxue Zhang, Guy A. E. Vandenbosch, Niels Verellen, Ewald Janssens, Jiafu Wang, Benfeng Bai, Cheng‐Wei Qiu, Xuezhi Zheng   +14 more
wiley   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Inhibidores del complemento C5: mecanismos de acción, indicaciones, riesgo de infecciones y estrategias de prevención

Actualizaciones en Sida e Infectología
Los inhibidores del complemento C5, Eculizmab y Ravulizumab, son dos anticuerpos monoclona- les que se utilizan para el tratamiento de miastenia gravis (MG), trastorno del espectro de la neu- romielitis óptica (NMOSD, por sus siglas en inglés ...
Comisión de Infecciones en el Paciente Inmunocomprometido
doaj   +1 more source

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.

PLoS ONE, 2018
Modulating the complement system is a promising strategy in drug discovery for disorders with uncontrolled complement activation. Although some of these disorders can be effectively treated with an antibody that inhibits complement C5, the high plasma ...
Zenjiro Sampei, Kenta Haraya, Tatsuhiko Tachibana, Taku Fukuzawa, Meiri Shida-Kawazoe, Siok Wan Gan, Yuichiro Shimizu, Yoshinao Ruike, Shu Feng, Taichi Kuramochi, Masaru Muraoka, Takehisa Kitazawa, Yoshiki Kawabe, Tomoyuki Igawa, Kunihiro Hattori, Junichi Nezu   +15 more
doaj   +1 more source

Effect of the pH-dependent C5-binding property on C5 clearance and antibody PK in mice.

, 2018
Human C5 (0.1 mg/kg) with or without an anti-C5 antibody (20 mg/kg) was intravenously administered to human FcRn transgenic mice. Time profiles of human C5 concentration (A) or anti-C5 antibody concentration (B) are shown.
Yoshinao Ruike (6162533), Taku Fukuzawa (381717), Junichi Nezu (6162542), Taichi Kuramochi (6162536), Kunihiro Hattori (384401), Tatsuhiko Tachibana (384397), Takehisa Kitazawa (384392), Yoshiki Kawabe (381729), Kenta Haraya (384396), Siok Wan Gan (506317), Tomoyuki Igawa (384385), Zenjiro Sampei (384384), Meiri Shida-Kawazoe (6162530), Yuichiro Shimizu (2722471), Shu Feng (391684), Masaru Muraoka (6162539)   +15 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

A fusion protein of the two tick-derived C5 inhibitors OmCI and RaCI: complete C5 inhibition despite strong complement activation

Immunobiology
The complement system must be tightly regulated to prevent tissue damage and disease, yet current C5 inhibitors like the anti-C5 monoclonal antibody Eculizumab – though clinically approved ( e.g. , for paroxysmal nocturnal haemoglobinuria, PNH) - fail to
Sümeyye Erdemci-Evin, Verena Kaupper, Jannik Sichau, Elsa Dopler, Hiba Ghaboosh, Arthur Dopler, Christoph Q. Schmidt   +6 more
doaj   +1 more source

C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2

, 2011
C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A21. Liquiritigenin (7,4'-dihydroxyflavone), the primary active component of a traditional Chinese medicine Glycyrrhizae radix, has a wide range of pharmacological activities.
Tu, Cai-Xia, Hu, Ying, Wang, Ao-Xue, Liu, Hui-Xin, Hui-XinLiu, Liu, Yong, Qi, Xiao-Yi, Yang, Ling   +7 more
core   +1 more source