Results 101 to 110 of about 30,655 (265)
Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper
Allergy, EarlyView.ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres +19 more
wiley +1 more source
Brain Pathology, EarlyView.C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara +9 more
wiley +1 more source
HeliyonObjective: Diverse inflammatory pathology is involved in acute respiratory distress syndrome (ARDS). This study aimed to assess the role of complement component fragment 5a (C5a) receptor 2 (C5aR2) in prognosis of patients with ARDS.
Muhammed Rashid +9 more
doaj +1 more source
Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock
Mediators of Inflammation, 2018 Background. Polymorphonuclear granulocytes (PMN) play a crucial role in host defense. Physiologically, exposure of PMN to the complement activation product C5a results in a protective response against pathogens, whereas in the case of systemic ...
David A. C. Messerer +12 more
doaj +1 more source
Characterisation of C5a receptor agonists from phage display libraries
, 2003 C5a des-Arg74 has a 10- to 100-fold lower receptor binding affinity than intact C5a and is only a partial agonist. We have used phage display selection from randomly mutated C5a des-Arg74 libraries to isolate variant proteins that can activate C5a ...
Monk, Peter N. +2 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Kininase I, comprising carboxypeptidase N (CPN) and carboxypeptidase M, regulates kinin activity and is up‐regulated during injury, inflammation and immune activation. Under these conditions, kininase I converts bradykinin and kallidin into des‐Arg kinins, primary endogenous agonists of the bradykinin B1 receptor (R ...
Acacia White +5 more
wiley +1 more source
Role of C5 Activation Products in Sepsis
The Scientific World Journal, 2010 Complement activation products are known to be generated in the setting of both experimental and human sepsis. C5 activation products (C5a anaphylatoxin and the membrane attack complex [MAC] C5b-9) are generated during sepsis following infusion of ...
Peter A. Ward
doaj +1 more source
Development of C5a receptor antagonists
, 1999 During host defense, the human complement system of plasma proteins initiates inflammatory and cellular immune responses to stimuli such as infectious organisms, chemical and physical injury, radiation and neoplasia.
Taylor, S. M., Fairlie, D., Wong, A.
core
SdrE expression reduces C5a generation.
, 2013 L. lactis were incubated with various concentrations of NHS at 37°C. Supernatants were assessed for C5a content via C5a ELISA.
Julia A. Sharp (320880) +7 more
core +1 more source
A study of the molecular pharmacological properties of C5a and C5a des Arg: defining their biased agonist profile and contrasting biological function [PDF]
The complement system provides an essential role in the orchestration of an effective immune response against microbial infection. Activation leads to the generation of C5a which activates receptors expressed on immune cells promoting microbial ...
Ramsey, SJ
core +1 more source