Results 91 to 100 of about 28,519 (248)
Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Journal of Neuroinflammation, 2022 Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho +10 more
doaj +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source
NOD2-mediated suppression of CD55 on neutrophils enhances C5a generation during polymicrobial sepsis. [PDF]
PLoS Pathogens, 2013 Nucleotide-binding oligomerization domain (NOD) 2 is a cytosolic protein that plays a defensive role in bacterial infection by sensing peptidoglycans. C5a, which has harmful effects in sepsis, interacts with innate proteins.
Sae Jin Oh, Ji Hyung Kim, Doo Hyun Chung
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Contractile actions of C5a on isolated porcine myocardium [PDF]
, 1992 Although intracoronary administration of the complement component, C5a, produces deleterious effects on regional coronary blood flow and segmental ventricular function, it is unclear whether a direct myocardial action contributes to the dysfunction ...
J. C. Longhurst +2 more
core +1 more source
European Journal of Inorganic Chemistry, EarlyView.Upon reduction of 1,4‐diaza‐1,3‐diene 1 to the dilithium enediamide 2, the polarity of the C = N bonds is reversed ‐ a classic case of umpolung. This behavior is particularly evident in reactions of the dianion 2 with carbonyl compounds and also explains why 1,4‐diaza‐1,3‐diene ligands do not always act merely as spectator ligands. 1,4‐Diaza‐1,3‐dienes
Muhan Liang +3 more
wiley +1 more source
Development of C5a receptor antagonists [PDF]
, 1999 During host defense, the human complement system of plasma proteins initiates inflammatory and cellular immune responses to stimuli such as infectious organisms, chemical and physical injury, radiation and neoplasia.
Taylor, S. M., Fairlie, D., Wong, A.
core
Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand [PDF]
, 1999 Despite the expression of only one type of receptor, there is great variation in the ability of different cell types to discriminate between C5a and its more stable metabolite, C5a des Arg74. The mechanism that underlies this phenomenon is not understood
Monk, Peter N. +4 more
core +1 more source
Regulatory effects of C5a on IL-17A, IL-17F, and IL-23
Frontiers in Immunology, 2013 The complement anaphylatoxin, C5a, through binding to its receptors (C5aR or C5L2), has important biological properties for recruitment and activation of phagocytes.
Jamison J. Grailer +2 more
doaj +1 more source
Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients
Frontiers in Immunology, 2020 Initially underestimated as platelet dust, extracellular vesicles are continuously gaining interest in the field of inflammation. Various studies addressing inflammatory diseases have shown that microvesicles (MVs) originating from different cell types ...
Ebru Karasu +10 more
doaj +1 more source
Intensive Care Medicine Experimental, 2023 Background Vilobelimab, a complement 5a (C5a)-specific monoclonal antibody, reduced mortality in critically ill COVID-19 patients in a phase 3 multicentre, randomized, double-blind, placebo-controlled study.
Endry H. T. Lim +12 more
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