Results 181 to 190 of about 24,312 (217)

Human T Cells Express the C5a Receptor and Are Chemoattracted to C5a

The Journal of Immunology, 1999
Abstract The anaphylatoxin C5a is a potent mediator of inflammation that exerts a broad range of activity on cells of the myeloid lineage. In this study, we present the first evidence that human T cells express the C5a receptor (C5aR) and are chemotactic to C5a.
S, Nataf, N, Davoust, R S, Ames, S R, Barnum   +3 more
openaire   +2 more sources

Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor

Biochemistry, 2008
This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure analyzing various conformational possibilities of the extracellular loops and the N-terminal segment of ...
Gregory V, Nikiforovich, Garland R, Marshall, Thomas J, Baranski   +2 more
openaire   +2 more sources

The Human Mast Cell Line HMC‐1 Expresses C5a Receptors and Responds to C5a but not to C5a(desArg)

Scandinavian Journal of Immunology, 1996
The expression of the receptor for the anaphylatoxin C5a (C5aR, CD88) on the human mast cell line HMC‐1 was studied with four anti‐C5aR monoclonal antibodies directed to the N‐terminal domain of the receptor. All antibodies bound to the human mast cell line HMC‐1.
T, Werfel, M, Oppermann, J H, Butterfield, G, Begemann, J, Elsner, O, Götze, J, Zwirner   +6 more
openaire   +2 more sources

Anaphylatoxins: C3a and C5a

1978
Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
openaire   +2 more sources

Mapping the Ligand-Binding Site on the C5a Receptor:  Arginine⁷⁴ of C5a Contacts Aspartate²⁸² of the C5a Receptor

Biochemistry, 2001
The interaction between the anaphylatoxin C5a and its receptor involves two distinct sites. One site is formed by acidic residues at the receptor N-terminus and contributes to only ligand binding. The second site, responsible for activation, is less well defined.
Cain, S. A.; id_orcid 0000-0001-8417-1058, Coughlan, T., Monk, P. N.   +2 more
openaire   +2 more sources

A selection system to study C5a–C5a-receptor interactions: Phage display of a novel C5a anaphylatoxin, Fos-C5aAla27

Gene, 1997
Binding and effector domains of the human anaphylatoxin C5a have been determined by either site directed mutagenesis or synthetic peptide studies. However, the lack of specific selection methods, which allow direct investigation of C5a-C5a-receptor interaction made these studies laborious.
M, Hennecke, A, Kola, M, Baensch, A, Wrede, A, Klos, W, Bautsch, J, Köhl   +6 more
openaire   +2 more sources

Tc-99m-labeled C5a and C5a des Arg74 for infection imaging

Nuclear Medicine and Biology, 2003
The complement anaphylatoxin C5a and its natural metabolite C5a des Arg(74) (C5adR) are involved in several stages of the inflammatory process. Both act on a common receptor expressed on different cell types, including neutrophils and monocytes. The receptor binding affinity of C5a is in the nanomolar range and exceeds that of C5adR by 1-2 orders of ...
Rennen, H. J., Oyen, W. J., Cain, S. A.; id_orcid 0000-0001-8417-1058, Monk, P. N., Corstens, F. H., Boerman, O. C.   +5 more
openaire   +4 more sources

C5a

2011
openaire   +1 more source

Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist

Science China Chemistry, 2019
Jiawei Wang, Lei Liu, Donald Bierer
exaly  

C5a-Stimulated Recruitment of β-Arrestin2 to the Nonsignaling 7-Transmembrane Decoy Receptor C5L2

SLAS Discovery, 2009
Guido Zaman, Andrea Van Elsas
exaly