Results 181 to 190 of about 51,606 (244)

A Targeted Blockade of Terminal C5a Is Critical to Management of Sepsis and Acute Respiratory Distress Syndrome: The Mechanism of Action of Vilobelimab. [PDF]

Int J Mol Sci
McCarthy MW, Chong C, Riedemann NC, Guo R.   +3 more
europepmc   +1 more source

The free fatty acid 2 receptor regulates the activation potency of C5a and the sensitivity to the antagonist avacopan

Khan Z, Levin NK, Dahlgren C, Sundqvist M, Khan F, Forsman H, Björkman L.   +6 more
europepmc   +1 more source

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors

Tiwari D, Sawada K, Dalal A, Mishra S, Li XX, Dent JC, Kim K, Yadav MK, Roy N, Ganguly M, Banerjee N, Stepniewski TM, Ahn D, Yamaguchi K, Oshima HS, Hashimoto K, Fung JN, Lerskiatiphanich T, Cui CS, Lee JD, Selent J, Inoue A, Clark R, Chung KY, Banerjee R, Sano FK, Woodruff TM, Nureki O, Shukla AK.   +28 more
europepmc   +1 more source

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Complement component 5a (C5a)

International Journal of Biochemistry and Cell Biology, 2009
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert
Trent M Woodruff
exaly   +4 more sources

Human C5a and C5a analogs as probes of the neutrophil C5a receptor

Molecular Immunology, 1980
Abstract Quantitative assessment of the human neutrophil chemotactic response and immunologic evidence demonstrate that human C5a and/or its physiological equivalent, C5a des Arg' serves as the predominant chemotactic factor in complement activated serum.
D E, Chenoweth, T E, Hugli
openaire   +2 more sources

Tc-99m-labeled C5a and C5a des Arg74 for infection imaging

Nuclear Medicine and Biology, 2003
The complement anaphylatoxin C5a and its natural metabolite C5a des Arg(74) (C5adR) are involved in several stages of the inflammatory process. Both act on a common receptor expressed on different cell types, including neutrophils and monocytes. The receptor binding affinity of C5a is in the nanomolar range and exceeds that of C5adR by 1-2 orders of ...
Rennen, H. J., Oyen, W. J., Cain, S. A., Monk, P. N., Corstens, F. H., Boerman, O. C.   +5 more
openaire   +4 more sources

A selection system to study C5a–C5a-receptor interactions: Phage display of a novel C5a anaphylatoxin, Fos-C5aAla27

Gene, 1997
Binding and effector domains of the human anaphylatoxin C5a have been determined by either site directed mutagenesis or synthetic peptide studies. However, the lack of specific selection methods, which allow direct investigation of C5a-C5a-receptor interaction made these studies laborious.
M, Hennecke, A, Kola, M, Baensch, A, Wrede, A, Klos, W, Bautsch, J, Köhl   +6 more
openaire   +2 more sources

Anaphylatoxins: C3a and C5a

1978
Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
openaire   +2 more sources