Results 171 to 180 of about 24,312 (217)
Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities. [PDF]
Compr PhysiolAl Matni MY +3 more
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Restoring the glioblastoma tumor microenvironment by targeting C5a with the antagonist W54011. [PDF]
Sci RepOh Y +9 more
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1,3'-Dimethyl-2-oxo-6'-phenyl-7'<i>H</i>-spiro-[indoline-3,4'-isoxazolo[5,4-<i>b</i>]pyridine]-5'-carbo-nitrile. [PDF]
IUCrdataLogalakshmi S +4 more
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5-{4-[(1<i>R</i>,3<i>S</i>,4<i>S</i>)-Neomenth-yloxy]phen-yl}-1<i>H</i>-tetra-zole. [PDF]
IUCrdataDetert H, Schollmeyer D.
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Complement Dysregulation in Kidney Diseases: Mechanisms, Biomarkers, and Emerging Targeted Therapies. [PDF]
Int J Mol SciJesiołowski P +3 more
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Human C5a and C5a analogs as probes of the neutrophil C5a receptor
Molecular Immunology, 1980Abstract Quantitative assessment of the human neutrophil chemotactic response and immunologic evidence demonstrate that human C5a and/or its physiological equivalent, C5a des Arg' serves as the predominant chemotactic factor in complement activated serum.
Tony E Hugli, D E Chenoweth, T E Hugli
exaly +3 more sources
Immunology and Cell Biology, 2013
Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Daniel Croker +2 more
exaly +6 more sources
Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Daniel Croker +2 more
exaly +6 more sources
International Journal of Biochemistry and Cell Biology, 2009
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert
Helga Manthey +2 more
exaly +6 more sources
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor, CD88, C5a and C5adesArg exert
Helga Manthey +2 more
exaly +6 more sources
Pharmacological activity of C5a and peptide analogues of C5a [PDF]
, 2022 The activation of the blood borne complement system results in the production of the anaphylatoxin C5a. The interaction of C5a with its receptor leads to activation of inflammatory cells. The inappropriate and excessive production of C5a has been implicated in numerous inflammatory disease states, including arthritis and Alzheimer's disease. At present
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Role of C5a and C5a Receptor in Sepsis
2006In experimental sepsis (after cecal ligation and puncture, CLP) there is convincing evidence of complement activation, as there is in human sepsis. In addition, in sepsis involving rodents and humans, blood neutrophils have lost innate immune functions (chemotaxis, phagocytosis, the ability to produce H2O2).
F. S. Zetoune +2 more
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