Results 151 to 160 of about 6,229 (213)
Xenotransplantation, Volume 33, Issue 5, September/October 2026.ABSTRACT Xenotransplantation represents a potential solution to the persistent global organ shortage, yet its clinical application remains stalled by complex immunologic responses, coagulation dysregulation, species‐specific biology, and infectious risks.
Kasra Shirini +7 more
wiley +1 more source
American Journal of Hematology, Volume 101, Issue 10, Page 2666-2671, October 2026.
Kenneth I. Ataga +8 more
wiley +1 more source
Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis
European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley +1 more source
Etude du potentiel neurorégénérateur de la protéine C5a du complément
Central nervous system injury is considered as a degenerative disease with no effective therapy to restore the lost functions. Injured axons are unable to grow and reconnect to their original targets due to an unfavorable environment.
Cotten, Aurélie
core +1 more source
Enhancement of Macrophage Phagocytosis by Complement Component C5a
To investigate the modulatory function of complement component C5a in macrophages, the effects of C5a on macrophage phagocytosis were examined by means of fluorescent polystyrene particles and flow cytometry.
Ichinose, Mitsuyuki, Hirota, Akihiko
core
Immunology and Cell Biology, 2013 Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Daniel Croker +2 more
exaly +7 more sources
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Human C5a and C5a analogs as probes of the neutrophil C5a receptor
Molecular Immunology, 1980Abstract Quantitative assessment of the human neutrophil chemotactic response and immunologic evidence demonstrate that human C5a and/or its physiological equivalent, C5a des Arg' serves as the predominant chemotactic factor in complement activated serum.
Tony E Hugli, D E Chenoweth
exaly +3 more sources
Biochemistry, 2001 The interaction between the anaphylatoxin C5a and its receptor involves two distinct sites. One site is formed by acidic residues at the receptor N-terminus and contributes to only ligand binding. The second site, responsible for activation, is less well defined.
Cain, S. A.; id_orcid 0000-0001-8417-1058 +2 more
openaire +3 more sources
Tc-99m-labeled C5a and C5a des Arg74 for infection imaging
Nuclear Medicine and Biology, 2003 The complement anaphylatoxin C5a and its natural metabolite C5a des Arg(74) (C5adR) are involved in several stages of the inflammatory process. Both act on a common receptor expressed on different cell types, including neutrophils and monocytes. The receptor binding affinity of C5a is in the nanomolar range and exceeds that of C5adR by 1-2 orders of ...
Rennen, H. J. +5 more
openaire +5 more sources
International Journal of Biochemistry and Cell Biology, 2009 The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade.
Helga Manthey +2 more
exaly +2 more sources