Results 141 to 150 of about 6,229 (213)

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Complement 5 (C5); C5a; C5a receptor [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

A First‐in‐Japanese Phase 1, Double‐Blind, Placebo‐Controlled, Parallel‐Cohort Study of Sefaxersen, an Antisense Oligonucleotide Targeting Complement Factor B, in Healthy Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 9, September 2026.
Abstract Increased activity in the complement alternative pathway (AP) plays a key role in diseases such as IgA nephropathy (IgAN). This first‐in‐Japanese double‐blind Phase 1 study investigated the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of sefaxersen (RO7434656), an antisense oligonucleotide targeting complement factor ...
Takakazu Sato, Hiroyuki Fukase, Takaaki Ishida, Arisa Karasawa   +3 more
wiley   +1 more source

Cancer cell‐selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumour immunotherapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong, Yile Wang, Yunqi Zhao, Lu Wang, Zhimin Fan, Yongqian Shu, Jinke Wang   +6 more
wiley   +1 more source

Integrative Transcriptomic Analysis and Functional Validation Implicate GPT2 in Glycolytic Regulation in Polycystic Ovary Syndrome

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Integrating GEO transcriptomic datasets, machine‐learning algorithms, GSVA, multilayer regulatory network and immune infiltration analyses, this study revealed metabolic‐immune disturbance and aberrant ovarian steroidogenesis in polycystic ovary syndrome (PCOS).
Meili Xi, Rongkui Luo, Jiarong Zhang, Weihong Huang, Li Ma, Yunyan Sun, Aimin Ren   +6 more
wiley   +1 more source

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model

Glia, Volume 74, Issue 9, September 2026.
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Tiffany J. Petrisko, Shu‐Hui Chu, Angela Gomez‐Arboledas, Blossom Zhang, Andrea J. Tenner   +4 more
wiley   +1 more source

Cytokine‐Driven Hyperinflammation in Long COVID: Mechanisms, Biomarkers, Complement Dysregulation, and Emerging Immunotherapies—A Narrative Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Long COVID, also known as post‐acute sequelae of SARS‐CoV‐2 infection (PASC), is a multisystem condition characterized by persistent symptoms that continue beyond the acute phase of infection. Growing evidence indicates that sustained immune dysregulation involving cytokine‐mediated inflammation, complement activation ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

2‐Hydroxyethyl Methacrylate Increases MMP‐1 and MMP‐3 Production in Human Gingival Fibroblasts

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
HEMA induces the production of MMP‐1 and MMP‐3 in human gingival fibroblasts by activating the p38 MAPK, JNK, and Akt signaling pathways. ABSTRACT 2‐Hydroxyethyl methacrylate (HEMA), a monomer commonly used in dental resin materials, has been reported to leach from polymerized resins.
Risa Okamoto, Yoshitaka Hosokawa, Ikuko Hosokawa, Ai Fukui, Natsuho Miyake, Kazumi Ozaki, Keiichi Hosaka   +6 more
wiley   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

An Approach to Antibody‐Mediated Rejection in Pediatric Liver Transplantation

Pediatric Transplantation, Volume 30, Issue 9, September 2026.
ABSTRACT Antibody‐mediated rejection (AMR) is an important but infrequent cause of pediatric liver allograft injury. There is a lack of standardized guidance, and treatment approaches vary across institutions. A writing group from the Society of Pediatric Liver Transplantation conducted a comprehensive review of the published literature and collected ...
Catalina Jaramillo, Parmjeet Randhawa, Amrita Narang, Alison J. Gareau, Jody Weckwerth, Alisha Mavis, George Mazariegos, Katryn Furuya, Nanda Kerkar   +8 more
wiley   +1 more source