Results 131 to 140 of about 30,655 (265)
The Journal of Physiology, EarlyView.Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo +4 more
wiley +1 more source
Enhancement of Macrophage Phagocytosis by Complement Component C5a
, 1998 To investigate the modulatory function of complement component C5a in macrophages, the effects of C5a on macrophage phagocytosis were examined by means of fluorescent polystyrene particles and flow cytometry.
Ichinose, Mitsuyuki, Hirota, Akihiko
core +1 more source
International Journal of Cancer, Volume 159, Issue 11, Page 2824-2834, 1 December 2026.ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött +17 more
wiley +1 more source
, 2019 SAT-302 INHIBITION OF COMPLEMENT C5A/C5A RECEPTOR 1 DECREASES RENAL INJURY IN DIABETIC KIDNEY DISEASE VIA METABOLIC ...
Mark Ziemann (13101363) +7 more
core
Endotoxins and Biological Implications—Review
Public Health Challenges, Volume 5, Issue 4, December 2026.Graphical overview of endotoxin sources, exposure routes, biological effects, detection methods, and routes of elimination. ABSTRACT Endotoxins, also known as lipopolysaccharides (LPSs), are structural components of the outer membrane of Gram‐negative bacteria and some cyanobacteria.
Uzair Ishtiaq +5 more
wiley +1 more source
Adaptive Immunity in Marsupials
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol +2 more
wiley +1 more source
C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling
, 2020 Critical illness is accompanied by the release of large amounts of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of neutrophils which is associated with adverse outcomes.
Chilvers ER +13 more
core +1 more source
ACR Open Rheumatology, Volume 8, Issue 10, October 2026.Objective Complement activation, particularly through the C5a–C5a receptor axis, plays a pivotal role in the pathogenesis of antineutrophil cytoplasmic antibody–associated vasculitis (AAV) and may represent an important therapeutic target. Avacopan, an oral C5a receptor antagonist, was the first therapy targeting this pathway to enter in clinical ...
Luca Quartuccio +33 more
wiley +1 more source
From Molecular Targets to Advanced Delivery Systems: Aptamers for Precision Ocular Therapeutics
Advanced Therapeutics, Volume 9, Issue 10, October 2026.Aptamer‐based strategies are revolutionizing ocular disease management through highly specific molecular recognition of disease specific molecular targets. This review systematically integrates therapeutic aptamer sequences, diagnostic aptasensor platforms, and targeted delivery strategies, highlighting design principles, ocular bioavailability ...
Minal Thacker +4 more
wiley +1 more source