Results 161 to 170 of about 6,229 (213)

Complement C5a acts as molecular adjuvant in fish by enhancing antibody response to soluble antigen

Fish and Shellfish Immunology, 2014
C5a, the most potent anaphylatoxin generated during complement activation, has important proinflammatory actions and has also been shown to enhance antigen-specific antibody response in mammals, thereby acting as a molecular adjuvant.
Oriol Sunyer, Yong-An Zhang
exaly   +2 more sources

Pharmacological activity of C5a and peptide analogues of C5a [PDF]

, 2022
The activation of the blood borne complement system results in the production of the anaphylatoxin C5a. The interaction of C5a with its receptor leads to activation of inflammatory cells. The inappropriate and excessive production of C5a has been implicated in numerous inflammatory disease states, including arthritis and Alzheimer's disease. At present
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Role of C5a and C5a Receptor in Sepsis

2006
In experimental sepsis (after cecal ligation and puncture, CLP) there is convincing evidence of complement activation, as there is in human sepsis. In addition, in sepsis involving rodents and humans, blood neutrophils have lost innate immune functions (chemotaxis, phagocytosis, the ability to produce H2O2).
F. S. Zetoune, P. A. Ward, M. S. Huber-Lang   +2 more
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Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist

Biochemical Pharmacology, 2000
A cyclic peptide, Phe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg] (F-[OPdChaWR]), was recently shown in vitro to antagonise the binding of C5a to its receptor (CD88) on human polymorphonuclear leukocytes (PMNs) and in vivo to inhibit the neutropenia associated
Damien Harkin, David Fairlie, Stephen Taylor   +2 more
exaly   +2 more sources

Human T Cells Express the C5a Receptor and Are Chemoattracted to C5a

The Journal of Immunology, 1999
Abstract The anaphylatoxin C5a is a potent mediator of inflammation that exerts a broad range of activity on cells of the myeloid lineage. In this study, we present the first evidence that human T cells express the C5a receptor (C5aR) and are chemotactic to C5a.
S, Nataf, N, Davoust, R S, Ames, S R, Barnum   +3 more
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Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor

Biochemistry, 2008
This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure analyzing various conformational possibilities of the extracellular loops and the N-terminal segment of ...
Gregory V, Nikiforovich, Garland R, Marshall, Thomas J, Baranski   +2 more
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The Human Mast Cell Line HMC‐1 Expresses C5a Receptors and Responds to C5a but not to C5a(desArg)

Scandinavian Journal of Immunology, 1996
The expression of the receptor for the anaphylatoxin C5a (C5aR, CD88) on the human mast cell line HMC‐1 was studied with four anti‐C5aR monoclonal antibodies directed to the N‐terminal domain of the receptor. All antibodies bound to the human mast cell line HMC‐1.
T, Werfel, M, Oppermann, J H, Butterfield, G, Begemann, J, Elsner, O, Götze, J, Zwirner   +6 more
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Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain

British Journal of Pharmacology, 2008
particularly neutrophil chemoattraction. Herein, the role of C5a in the genesis of inflammatory hypernociception was investigated in rats and mice using the specific C5a receptor antagonist PMX53 (AcF-[OP(D-Cha)WR])
Thiago Mattar Cunha, Trent Woodruff, Verri Wa   +2 more
exaly   +2 more sources

Anaphylatoxins: C3a and C5a

1978
Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
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A selection system to study C5a–C5a-receptor interactions: Phage display of a novel C5a anaphylatoxin, Fos-C5aAla27

Gene, 1997
Binding and effector domains of the human anaphylatoxin C5a have been determined by either site directed mutagenesis or synthetic peptide studies. However, the lack of specific selection methods, which allow direct investigation of C5a-C5a-receptor interaction made these studies laborious.
M, Hennecke, A, Kola, M, Baensch, A, Wrede, A, Klos, W, Bautsch, J, Köhl   +6 more
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