Results 191 to 200 of about 1,253,157 (246)

Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a. [PDF]

PLoS Biol
Kiran A, Thomason PA, Versluis DM, Paschke PI, Donnelly H, Tweedy L, Lilla S, Bravo-Ferrer I, Shergold A, Devlin R, Roberts EW, Insall RH.   +11 more
europepmc   +1 more source

Complement C5a Promotes Epithelial-Mesenchymal Transition in Pterygium via C5aR Activation. [PDF]

Invest Ophthalmol Vis Sci
Han J, Gong Q, Wang H, Xie B, Ye L, Shen L, Hu L.   +6 more
europepmc   +1 more source

Advances in the Diagnosis, Treatment and Prognosis of ANCA-Associated Glomerulonephritis. [PDF]

Medicina (Kaunas)
Chalkia A, Petras D.
europepmc   +1 more source

Complement in acute kidney injury: a convergent pathogenic pathway in multifactorial renal damage. [PDF]

Front Immunol
Yi D, Yang R, Guo Y, Zhou H, Luan J.
europepmc   +1 more source

Correction to Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR 1) in lupus nephritis: A novel therapeutic target. [PDF]

J Cell Commun Signal
europepmc   +1 more source

Mapping the Ligand-Binding Site on the C5a Receptor:  Arginine⁷⁴ of C5a Contacts Aspartate²⁸² of the C5a Receptor

Biochemistry, 2001
The interaction between the anaphylatoxin C5a and its receptor involves two distinct sites. One site is formed by acidic residues at the receptor N-terminus and contributes to only ligand binding. The second site, responsible for activation, is less well defined.
Cain, S. A.; id_orcid 0000-0001-8417-1058, Coughlan, T., Monk, P. N.   +2 more
openaire   +3 more sources

Inhibiting the C5–C5a receptor axis

Molecular Immunology, 2011
Activation of the complement system is a major pathogenic event that drives various inflammatory responses in numerous diseases. All pathways of complement activation lead to cleavage of the C5 molecule generating the anaphylatoxin C5a and, C5b that subsequently forms the terminal complement complex (C5b-9).
Woodruff, Trent M., Nandakumar, Kutty S., Tedesco, Francesco   +2 more
openaire   +6 more sources

Development of C5a receptor antagonists.

IDrugs : the investigational drugs journal, 1999
During host defense, the human complement system of plasma proteins initiates inflammatory and cellular immune responses to stimuli such as infectious organisms, chemical and physical injury, radiation and neoplasia. Elevated levels of one of these plasma proteins C5a, a 74 amino acid peptidic anaphylatoxin which is one of the most potent pro ...
Wong, A., Taylor, S. M., Fairlie, D.
openaire   +3 more sources

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Human C5a and C5a analogs as probes of the neutrophil C5a receptor

Molecular Immunology, 1980
Abstract Quantitative assessment of the human neutrophil chemotactic response and immunologic evidence demonstrate that human C5a and/or its physiological equivalent, C5a des Arg' serves as the predominant chemotactic factor in complement activated serum.
D E, Chenoweth, T E, Hugli
openaire   +2 more sources