Results 71 to 80 of about 1,255,490 (262)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

CD177-mediated nanoparticle targeting of human and mouse neutrophils. [PDF]

PLoS ONE, 2018
Neutrophils are the most abundant white blood cells, with a vital role in innate immune defense against bacterial and fungal pathogens. Although mostly associated with pathological processes directly related to immune defense, they can also play a ...
Heini M Miettinen, Jeannie M Gripentrog, Connie I Lord, Jon O Nagy   +3 more
doaj   +1 more source

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a

, 1999
Activation of the human complement system of plasma proteins during immunological host defense can result in overproduction of potent proinflammatory peptides such as the anaphylatoxin C5a.
Wadi, S. K., Fairlie, D., Taylor, S. M., Wong, A. K., Paczkowski, N. J., Craik, D. J., Finch, A., S. Khémar Wadi, Stephen M. Taylor, Allan K. Wong, David J. Craik, Natalii J. Paczkowski, Angela M. Finch, David P. Fairlie   +13 more
core   +1 more source

Subcorneal Pustular Dermatosis, a Systematic Review and Pooled Analysis of a Rare and Underdiagnosed Disease

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Subcorneal pustular dermatosis (SPD), or Sneddon–Wilkinson disease, is a rare, relapsing pustular skin condition of unknown cause, characterised by subcorneal pustules. Objectives To summarise the demographic, clinical, histopathological, management and disease course of SPD.
Mason H. Crossman, Jeffrey Weng, Alysha Vuong, Lawrence Lin, Zhao Feng Liu, Christopher Y. Chew   +5 more
wiley   +1 more source

Complement C5a/C5aR1 pathway facilitates glioblastoma progression via fostering glioma stem cell-macrophage symbiosis

Journal of Neuroinflammation
Tumor-associated macrophages (TAMs) symbiotically interact with glioma stem cells (GSCs) to facilitate GSCs stemness maintenance and glioblastoma (GBM) progression.
Hongtao Zhu, Lidong Cheng, Dan Liu, Yixuan Ma, Heng Fan, Shuting He, Wenjia Liang, Daluo Mei, Xiaoyu Ma, Ran Li, Hailong Mi, Junwen Wang, Jun Li, Xingjiang Yu, Suojun Zhang, Kai Shu   +15 more
doaj   +1 more source

Studies on the role of inflammation and stem cells in cardiac ischaemic injury [PDF]

, 2008
The regenerative capacity of human myocardium is unable to compensate adequately forth significant loss of heart muscle that occurs in acute myocardial infarction (Ml).
Ahmed, Ishtiaq M., Ahmed, Ishtiaq M
core  

Complement component 5a (C5a)

, 2009
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade.
Manthey, Helga D., Monk, Peter N., Woodruff, Trent M., Taylor, Stephen M.   +3 more
core   +1 more source

Therapeutic Potential of Targeting Complement C5a Receptors in Diabetic Kidney Disease

, 2023
Diabetic kidney disease (DKD) affects 30–40% of patients with diabetes and is currently the leading cause of end-stage renal disease (ESRD). The activation of the complement cascade, a highly conserved element of the innate immune system, has been ...
Sih Min Tan, Melinda T. Coughlan, Inez A. Trambas   +2 more
core   +1 more source

C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis

Frontiers in Immunology, 2019
Psoriasis is one of the most common chronic inflammatory skin diseases, affecting ~2% of the population. The lack of characterization of the pathogenesis of psoriasis has hindered efficient clinical treatment of the disease.
Quan-you Zheng, Quan-you Zheng, Shen-ju Liang, Feng Xu, Gui-qing Li, Na Luo, Shun Wu, You Li, Ming Tang, Yu Zhong, Jian Chen, Di Yang, Dao-dong Sun, Ke-qin Zhang, Gui-lian Xu   +14 more
doaj   +1 more source

Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats

, 2011
Background and Objective: The complement activation product 5a (C5a) is a potent mediator of the innate immune response to infection, and may thus also importantly determine the development of periodontitis.
T. Breivik, Y. Gundersen, T. M. Woodruff, P. K. Opstad, Opstad, P. K., S. M. Taylor, Gjermo, P., Taylor, S. M., Breivik, T., P. Gjermo, Woodruff, T. M., Gundersen, Y.   +11 more
core   +1 more source