Results 71 to 80 of about 16,656 (99)

Human C5a and C5a analogs as probes of the neutrophil C5a receptor

Molecular Immunology, 1980
Abstract Quantitative assessment of the human neutrophil chemotactic response and immunologic evidence demonstrate that human C5a and/or its physiological equivalent, C5a des Arg' serves as the predominant chemotactic factor in complement activated serum.
D E, Chenoweth, T E, Hugli
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Ligands for C3a and C5a Receptors [PDF]

, 2023
Prolonged activation of the complement system of blood proteins in response to infection or tissue injury can lead to inflammatory diseases. This thesis investigates the potency, selectivity and structures of reported and rationally designed new ligands for human complement receptors C3aR and C5aR, towards development of new therapeutic agents. Chapter
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Mapping the Ligand-Binding Site on the C5a Receptor:  Arginine⁷⁴ of C5a Contacts Aspartate²⁸² of the C5a Receptor

Biochemistry, 2001
The interaction between the anaphylatoxin C5a and its receptor involves two distinct sites. One site is formed by acidic residues at the receptor N-terminus and contributes to only ligand binding. The second site, responsible for activation, is less well defined.
Cain, S. A.; id_orcid 0000-0001-8417-1058, Coughlan, T., Monk, P. N.   +2 more
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Inhibiting the C5–C5a receptor axis

Molecular Immunology, 2011
Activation of the complement system is a major pathogenic event that drives various inflammatory responses in numerous diseases. All pathways of complement activation lead to cleavage of the C5 molecule generating the anaphylatoxin C5a and, C5b that subsequently forms the terminal complement complex (C5b-9).
Woodruff, Trent M., Nandakumar, Kutty S., Tedesco, Francesco   +2 more
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Role of C5a and C5a Receptor in Sepsis

2006
In experimental sepsis (after cecal ligation and puncture, CLP) there is convincing evidence of complement activation, as there is in human sepsis. In addition, in sepsis involving rodents and humans, blood neutrophils have lost innate immune functions (chemotaxis, phagocytosis, the ability to produce H2O2).
F. S. Zetoune, P. A. Ward, M. S. Huber-Lang   +2 more
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Human T Cells Express the C5a Receptor and Are Chemoattracted to C5a

The Journal of Immunology, 1999
Abstract The anaphylatoxin C5a is a potent mediator of inflammation that exerts a broad range of activity on cells of the myeloid lineage. In this study, we present the first evidence that human T cells express the C5a receptor (C5aR) and are chemotactic to C5a.
S, Nataf, N, Davoust, R S, Ames, S R, Barnum   +3 more
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Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor

Biochemistry, 2008
This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure analyzing various conformational possibilities of the extracellular loops and the N-terminal segment of ...
Gregory V, Nikiforovich, Garland R, Marshall, Thomas J, Baranski   +2 more
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The chemotactic receptor for human C5a anaphylatoxin

Nature, 1991
Host defence and inflammatory responses are controlled and amplified by receptor-mediated events often initiated by a chemotactic factor that directs the approach of phagocytic cells. Complement receptors CR1 and CR3 are responsible for the phagocytic and adhesive properties of neutrophils, whereas the C5a receptor mediates the pro-inflammatory and ...
N P, Gerard, C, Gerard
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Analysis of C5a receptor by monoclonal antibody

Journal of Immunological Methods, 1995
We prepared a mouse monoclonal antibody (mAb), termed 4C8, to the human C5a receptor (C5aR, CD88) by fusing spleen cells from mice immunized with mouse Ltk- cells transfected with cDNA of human C5aR (Ltk-/C5aR) to the mouse myeloma cell line P3U1. This mAb belonging to the IgM kappa subclass, detected a 43 kDa band on cell lysates of Ltk-/C5aR by ...
H, Watanabe, M, Kuraya, R, Kasukawa, H, Yanagisawa, M, Yanagisawa, T, Fujita   +5 more
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Distribution of Rat C5a Anaphylatoxin Receptor

Microbiology and Immunology, 2002
AbstractThe anaphylatoxin, complement 5a (C5a), plays a key role in mediating various inflammatory reactions following complement activation. Several investigators have reported that C5a receptor (C5aR) is expressed in non‐myeloid cells under certain conditions or in different cell lines.
Hiroyasu, Akatsu, Masayoshi, Abe, Takashi, Miwa, Hisashi, Tateyama, Seiji, Maeda, Noriko, Okada, Kiyohide, Kojima, Hidechika, Okada   +7 more
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