Results 81 to 90 of about 1,255,490 (262)

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

SusMat, EarlyView.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang, Jiahao Liang, Xijing Yang, Xin Song, Yujie Xiao, Xiran Zhou, Hongyu Xiang, Shujing Wang, Shengjun Cheng, Xianda Liu, Yu Chen, Weifeng Zhao, Changsheng Zhao   +12 more
wiley   +1 more source

New developments in C5a receptor signaling

Cell Health and Cytoskeleton, 2012
Complement activation usually results in the formation of complement fragment 5a (C5a) that interacts with its two receptors, C5aR and C5L2. These receptors belong to the rhodopsin family of G protein-coupled seven transmembrane-containing receptors. C5aR and C5L2 are expressed on/in a wide variety of cells and tissues.
J Vidya, Sarma, Peter A, Ward
openaire   +3 more sources

Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor

, 2001
The cyclic C5a receptor antagonist, phenylalanine [L-ornithine-proline-D-cyclohexylalanine-tryptophan-arginine] (F-[OPchaWR]), has similar to 1000-fold less affinity for the C5a receptor (C5aR) on murine polymorphonuclear leukocytes than on human ...
Monk, Peter N., Sam D. Sanderson, Fairlie, David P., Peter N. Monk, Stephen M. Taylor, Taylor, S. M., Cain, Stuart A.; id_orcid, Sanderson, S. D., Cain, S. A., Taylor, Stephen M., Sanderson, Sam D., Woodruff, T. M., Woodruff, Trent M., Stuart A. Cain, Trent M. Woodruff, David P. Fairlie, Monk, P. N., Fairlie, D. P.   +17 more
core   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Increased local concentration of complement C5a contributes to incisional pain in mice

Journal of Neuroinflammation, 2011
Background In our previous study, we demonstrated that local injection of complement C5a and C3a produce mechanical and heat hyperalgesia, and that C5a and C3a activate and sensitize cutaneous nociceptors in normal skin, suggesting a contribution of ...
Clark David J, Sun Yuan, Kido Kanta, Liang Deyong, Jang Jun H, Brennan Timothy J   +5 more
doaj   +1 more source

The influence of Lys68 in decapeptide agonists of C5a on C5a receptor binding, activation and selectivity

, 1999
The potent, conformationally biased C5a agonist peptide YSFKPMPLaR (C5a(65-74), Y65, F67, P69, P71, D-Ala73) was used as a template to gain insight into the nature and importance of lysine at position 68 in the peptide-receptor interaction.
Vogen, S. M., S. M. Taylor, Taylor, S. M., Thatcher, J., J. Thatcher, Sanderson, S. D., Finch, A., P. N. Monk, Wadi, S. K., A. M. Finch, S. M. Vogen, S. K. Wadi, S. D. Sanderson, Monk, P. N.   +13 more
core   +1 more source

Deficiency of high‐molecular‐weight von Willebrand factor mitigates thrombo‐complement injury in an LPS‐induced TMA‐like mouse model

VIEW, EarlyView.
Reduction of high‐molecular‐weight von Willebrand factor disrupts the platelet–complement amplification loop, attenuating microvascular thrombosis, complement deposition, endothelial injury, and organ damage in complement‐mediated thrombotic microangiopathy.
Yang Li, Chihao Zhang, Xiaoqian Xu, Sicong Wang, Xiaofan Hu, Junjie Yao, Xi Wu, Difeng Zhu, Qian Liang, Yeling Lu, Yu Liu, Guanqun Xu, Jiakuan Zhou, Qiulan Ding, Wenman Wu, Ya Li, Jing Dai, Xuefeng Wang   +17 more
wiley   +1 more source

C5L2, a nonsignalling C5A receptor is uncoupled to G proteins

, 2008
THESIS 8414The complement anaphylatoxins are prominent mediators of host defence and inflammation. The small subunit of the fifth component of complement, C5a has complex effects in vivo including potential anti- and pro-inflammatory effects in acute ...
Slattery, Dubhfeasa Maire
core  

Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors [PDF]

, 2011
Mammary tumors are among the most common neoplastic conditions in dogs, and there is evidence that inflammation plays a role in the development of some tumor types in dogs.
Barbara Rolfe, Mohd Noor Mohd Hezmee, Lee, Jia Yu Peppermint, Shiels, Ian A., Kyaw-Tanner, Myat, Trent Woodruff, Ian A. Shiels, Lee, Jia Yu, Jia Yu Peppermint Lee, Hezmee, Mohd Noor Mohd, Mills, Paul C., Myat, Kyaw-Tannera, Rolfe, Barbara, Paul C. Mills, Myat Kyaw-Tanner, Woodruff, Trent, Mohd Noor, Mohd Hezmee   +16 more
core   +1 more source

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

VIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu, Lei Meng, Wenzhu Song, Peiyu Wang, Bin Liu, Shihui Liu, Qi He, Bing Sun, Wanheng Li, Zhiwei Guan, Rui Dong, Qiang Feng   +11 more
wiley   +1 more source