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The Alternative C5a Receptor Function
2012When acute inflammatory states are induced by treatment with chemical mediators in C5-deficient mice, neutrophil influxes are commonly decreased. Therefore, the neutrophil C5a receptor (C5aR) is believed to be a member of the pro-inflammatory receptors.
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Development of C5a receptor antagonists.
IDrugs : the investigational drugs journal, 1999During host defense, the human complement system of plasma proteins initiates inflammatory and cellular immune responses to stimuli such as infectious organisms, chemical and physical injury, radiation and neoplasia. Elevated levels of one of these plasma proteins C5a, a 74 amino acid peptidic anaphylatoxin which is one of the most potent pro ...
Wong, A., Taylor, S. M., Fairlie, D.
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The Human Mast Cell Line HMC‐1 Expresses C5a Receptors and Responds to C5a but not to C5a(desArg)
Scandinavian Journal of Immunology, 1996The expression of the receptor for the anaphylatoxin C5a (C5aR, CD88) on the human mast cell line HMC‐1 was studied with four anti‐C5aR monoclonal antibodies directed to the N‐terminal domain of the receptor. All antibodies bound to the human mast cell line HMC‐1.
T, Werfel +6 more
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Current pharmaceutical design, 1999
The anaphylatoxin C5a is an extremely potent proinflammatory peptide produced during activation of the complement system. The structure of C5a includes a core region (N-terminal residues 1-63) consisting of four, antiparallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail (residues 64-74).
T C, Pellas, L P, Wennogle
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The anaphylatoxin C5a is an extremely potent proinflammatory peptide produced during activation of the complement system. The structure of C5a includes a core region (N-terminal residues 1-63) consisting of four, antiparallel alpha-helices held together by three disulfide linkages and a structured C-terminal tail (residues 64-74).
T C, Pellas, L P, Wennogle
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The Journal of Immunology, 1993
Abstract The relationship of C5a receptor expression on human polymorphonuclear leukocytes (PMN) to the functional response of these cells to C5a was studied using flow cytometry. C5a receptor expression was determined with a fluorescein conjugate of C5a and oxidative burst activity was monitored by conversion of dichlorofluorescein ...
D E, Van Epps, S J, Simpson, R, Johnson
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Abstract The relationship of C5a receptor expression on human polymorphonuclear leukocytes (PMN) to the functional response of these cells to C5a was studied using flow cytometry. C5a receptor expression was determined with a fluorescein conjugate of C5a and oxidative burst activity was monitored by conversion of dichlorofluorescein ...
D E, Van Epps, S J, Simpson, R, Johnson
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Immunology & Cell Biology, 2013
Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Croker, Daniel E. +3 more
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Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated. There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like‐2 (C5L2) receptor. Here we hypothesized that activation of C5aR might lead to heteromer formation with C5L2, as a downregulatory
Croker, Daniel E. +3 more
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The C5a Receptor of Neutrophils and Macrophages
1983D E, Chenoweth, M G, Goodman
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