Results 81 to 90 of about 1,253,157 (246)

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain

, 2008
particularly neutrophil chemoattraction. Herein, the role of C5a in the genesis of inflammatory hypernociception was investigated in rats and mice using the specific C5a receptor antagonist PMX53 (AcF-[OP(D-Cha)WR])
E Ting, Cunha, F. Q., Guerrero, A. T. G., S M Taylor, Taylor, S. M., Ferreira, S. H., Cunha, T. M., VERRI JR., W. A., Ting, E., T M Cunha, T M Woodruff, A T G Guerrero, W A Verri, Verri, W. A., Woodruff, T. M., F Q Cunha, S H Ferreira   +16 more
core   +1 more source

Increased local concentration of complement C5a contributes to incisional pain in mice

Journal of Neuroinflammation, 2011
Background In our previous study, we demonstrated that local injection of complement C5a and C3a produce mechanical and heat hyperalgesia, and that C5a and C3a activate and sensitize cutaneous nociceptors in normal skin, suggesting a contribution of ...
Clark David J, Sun Yuan, Kido Kanta, Liang Deyong, Jang Jun H, Brennan Timothy J   +5 more
doaj   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

C5L2, a nonsignalling C5A receptor is uncoupled to G proteins

, 2008
THESIS 8414The complement anaphylatoxins are prominent mediators of host defence and inflammation. The small subunit of the fifth component of complement, C5a has complex effects in vivo including potential anti- and pro-inflammatory effects in acute ...
Slattery, Dubhfeasa Maire
core  

The influence of Lys68 in decapeptide agonists of C5a on C5a receptor binding, activation and selectivity

, 1999
The potent, conformationally biased C5a agonist peptide YSFKPMPLaR (C5a(65-74), Y65, F67, P69, P71, D-Ala73) was used as a template to gain insight into the nature and importance of lysine at position 68 in the peptide-receptor interaction.
Vogen, S. M., S. M. Taylor, Taylor, S. M., Thatcher, J., J. Thatcher, Sanderson, S. D., Finch, A., P. N. Monk, Wadi, S. K., A. M. Finch, S. M. Vogen, S. K. Wadi, S. D. Sanderson, Monk, P. N.   +13 more
core   +1 more source

C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps

The Journal of Clinical Investigation, 2023
Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death.
Bruna M. Silva, Giovanni F. Gomes, Flavio P. Veras, Seppe Cambier, Gabriel V.L. Silva, Andreza U. Quadros, Diego B. Caetité, Daniele C. Nascimento, Camilla M. Silva, Juliana C. Silva, Samara Damasceno, Ayda H. Schneider, Fabio Beretta, Sabrina S. Batah, Icaro M.S. Castro, Isadora M. Paiva, Tamara Rodrigues, Ana Salina, Ronaldo Martins, Guilherme C.M. Cebinelli, Naira L. Bibo, Daniel M. Jorge, Helder I. Nakaya, Dario S. Zamboni, Luiz O. Leiria, Alexandre T. Fabro, José C. Alves-Filho, Eurico Arruda, Paulo Louzada-Junior, Renê D. Oliveira, Larissa D. Cunha, Pierre Van Mol, Lore Vanderbeke, Simon Feys, Els Wauters, Laura Brandolini, Andrea Aramini, Fernando Q. Cunha, Jörg Köhl, Marcello Allegretti, Diether Lambrechts, Joost Wauters, Paul Proost, Thiago M. Cunha   +43 more
doaj   +1 more source

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

SusMat, EarlyView.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang, Jiahao Liang, Xijing Yang, Xin Song, Yujie Xiao, Xiran Zhou, Hongyu Xiang, Shujing Wang, Shengjun Cheng, Xianda Liu, Yu Chen, Weifeng Zhao, Changsheng Zhao   +12 more
wiley   +1 more source

Complement C5a acts as molecular adjuvant in fish by enhancing antibody response to soluble antigen

, 2014
C5a, the most potent anaphylatoxin generated during complement activation, has important proinflammatory actions and has also been shown to enhance antigen-specific antibody response in mammals, thereby acting as a molecular adjuvant.
Li, Jun, LaPatra, Scott E., Sunyer, J. Oriol, Zhang, Yong-An, Wu, Nan   +4 more
core   +1 more source

Role of C5aR2 in prognosis of patients with acute respiratory distress syndrome through negative modulation of C5a: A prospective observational study

Heliyon
Objective: Diverse inflammatory pathology is involved in acute respiratory distress syndrome (ARDS). This study aimed to assess the role of complement component fragment 5a (C5a) receptor 2 (C5aR2) in prognosis of patients with ARDS.
Muhammed Rashid, Sreedharan Nair, Pooja Gopal Poojari, Vijetha Shenoy Belle, Vijayanarayana Kunhikatta, Daniel A. Vaz, Vishal Shanbhag, Viji Pulikkel Chandran, Shravya Chitrapady, Girish Thunga   +9 more
doaj   +1 more source