Results 101 to 110 of about 1,255,490 (262)

Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats

, 2004
Objective. The capacity of a potent C5a receptor antagonist to inhibit various parameters of local and remote organ injury following lower limb ischemia-reperfusion (I/R) in rats was ...
Arumugam, Thiruma V., Fairlie, David P., Trent M Woodruff, Thiruma V Arumugam, Stephen M Taylor, Robert C Reid, Woodruff, Trent M., Shiels, Ian A., Reid, Robert C., Ian A Shiels, Taylor, Stephen M., David P Fairlie   +11 more
core   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Cloning and functional expression of the canine anaphylatoxin C5a receptor. Evidence for high interspecies variability.

, 1992
A cDNA clone, DTJP03, encoding an orphan receptor, was isolated from a canine thyroid library, and found to exhibit 68.6% amino-acid identity with the recently described human C5a receptor.
Raspé, Eric, Parmentier, Marc, Perret, Jason, Vassart, Gilbert   +3 more
core  

Protective effect of C5a receptor inhibition after murine reperfused stroke

, 2008
OBJECTIVE: The complement cascade has been implicated in cerebral ischemia/reperfusion injury. To develop clinically useful therapies that successfully manipulate the complement cascade, the individual roles of its components must be clearly defined ...
Mack, William J, Kim, Grace H, Komotar, Ricardo J, Kellner, Christopher P, Connolly, E. Sander, Ducruet, Andrew F, Hahn, David K, Mocco, J, Connolly, E Sander   +8 more
core   +1 more source

The Complement System in Post‐Transplant Kidney Injury

Organ Medicine, EarlyView.
Mengsi Hu
wiley   +1 more source

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH‐wildtype glioblastoma

Brain Pathology, EarlyView.
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara, Yosra Bedoui, Théotime Pignolet, Sebastien Freppel, Camille Brochard, Auguste Delattre, David Cappellen, Luc Bauchet, Mohamed Khettab, Franck Ah‐Pine   +9 more
wiley   +1 more source

Granulomatosis with polyangiitis and microscopic polyangiitis: pathogenesis and clinical manifestations

Современная ревматология
This literature review addresses the epidemiology, genetic markers, pathogenesis, clinical features, and diagnostic approaches of granulomatosis with polyangiitis and microscopic polyangiitis – both antineutrophil cytoplasmic antibody-associated ...
T. M. Reshetnyak, E. N. Vorkel, K. S. Nurbayeva, A. M. Lila   +3 more
doaj   +1 more source

Expression of C5a receptor in osteoblasts

The FASEB Journal, 2008
Anaphylatoxin C5a signaling plays an important role in inflammation‐associated bone diseases such as rheumatoid arthritis. However, expression and function of C5a receptor (C5aR) in the osteoblasts are largely unknown. The objective of this study is to determine C5aR expression and its function in the osteoblasts.
Tao Jiang, Hongwei Gao
openaire   +1 more source

Development of complement C5a and its receptor in malignant tumour cells as mammary tumour biomarker [PDF]

, 2015
Mammary cancer is the most common disease among women and second cause of female mortality related to cancer. The relationship between immune system and mammary cancer is still questionable.
Ganti, Norhaifa
core  

Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils

, 2011
It is well known that signaling in neutrophils through both the complement component 5a (C5a) and C5a receptor (C5aR) and the toll-like receptor 4 (TLR4) pathways plays an essential role in innate defense. Neutrophil dysfunction, as seen during sepsis in
Burvenich, Christian Paul G., Duchateau, Luc, M. Van Poucke, Van Poucke, Mario, Rainard, P, L.J. Peelman, Peelman, Luc, C. Burvenich, Van de Walle, Gerlinde, M.G.H. Stevens, G.R. Van de Walle, De Spiegeleer, Bart, P. Rainard, B. De Spiegeleer, L. Duchateau, Stevens, Mieke, Rogiers, Carolien, C. Rogiers, de Spiegeleer, B., van Poucke, M., Rogiers, C., Peelman, L.J., Stevens, M.G.H., Duchateau, Laure, van de Walle, G.R., Burvenich, Christian, Rainard, Pascal, P.   +26 more
core   +1 more source